Zobrazeno 1 - 10
of 414
pro vyhledávání: '"Colin Watts"'
Autor:
Sharon B. Love, Fay Cafferty, Claire Snowdon, Karen Carty, Joshua Savage, Philip Pallmann, Lucy McParland, Louise Brown, Lindsey Masters, Francesca Schiavone, Dominic Hague, Stephen Townsend, Claire Amos, Annabelle South, Kate Sturgeon, Ruth Langley, Timothy Maughan, Nicholas James, Emma Hall, Sarah Kernaghan, Judith Bliss, Nick Turner, Andrew Tutt, Christina Yap, Charlotte Firth, Anthony Kong, Hisham Mehanna, Colin Watts, Robert Hills, Ian Thomas, Mhairi Copland, Sue Bell, David Sebag-Montefiore, Robert Jones, Mahesh K. B. Parmar, Matthew R. Sydes
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-14 (2022)
Abstract Background Late-phase platform protocols (including basket, umbrella, multi-arm multi-stage (MAMS), and master protocols) are generally agreed to be more efficient than traditional two-arm clinical trial designs but are not extensively used.
Externí odkaz:
https://doaj.org/article/f16f51eff76c45b9b2545597e35df8a3
Autor:
Colin Watts
Publikováno v:
FEBS Open Bio, Vol 12, Iss 4, Pp 678-693 (2022)
The catabolic, degradative capacity of the endo‐lysosome system is put to good use in mammalian immune responses as is their recently established status as signaling platforms. From the ‘creative destruction’ of antigenic and ‘self’ materia
Externí odkaz:
https://doaj.org/article/d27b533554924d6f97dd71cdce4f574c
Autor:
Emily Rose Bligh, Conor Gillespie, Michael T.C. Poon, Georgios Solomou, Melissa Gough, Abdurrahman I. Islim, Christopher P. Millward, Ola Rominiyi, Rasheed Zakaria, Stephen J. Price, Colin Watts, Sophie Camp, Thomas C. Booth, Gerard Thompson, Samantha J. Mills, Adam Waldman, Paul Brennan, Michael D. Jenkinson
Publikováno v:
Brain and Spine, Vol 3, Iss , Pp 102127- (2023)
Externí odkaz:
https://doaj.org/article/7f53d8f63c514d8fa3efcec962d08813
Autor:
Ruichong Ma, Jonathan Cook, Giles Critchley, Damian Holliman, Chittoor Rajaraman, Amy Taylor, Peter McCulloch, Michael D Jenkinson, Paul M Brennan, Vicki S Barber, Huan Chan, Jose Lavrador, Keyoumars Ashkan, Neil Barua, Matthew Williams, Colin Watts, Dipankar Nandi, Stuart Smith, Luke Dixon, Robert Corns, Linda Dirven, Stephen John Price, Puneet Plaha, Erminia Albanese, Anna Solth, Helen Bulbeck, Grainne McKenna, Martin J B Taphoorn, James Palmer, Anil Varma, Maria Velicu, George Eralil, Kathrin Whitehouse, Sophie Camp, Natalie Voets, Matthew Grech-Sollars, Adrian Lim, Vasileios Apostolopoulos, Shailendra Achawal, Ganamurthy Sivakumar, Farouk Olubajo, Edward McKintosh, Dimitrios Paraskevopoulos, Paul Grundy
Publikováno v:
BMJ Open, Vol 12, Iss 11 (2022)
Introduction Surgery remains the mainstay for treatment of primary glioblastoma, followed by radiotherapy and chemotherapy. Current standard of care during surgery involves the intraoperative use of image-guidance and 5-aminolevulinic acid (5-ALA). T
Externí odkaz:
https://doaj.org/article/ad4f8c642a8343079d2060d703b77bf6
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Glioblastoma (GBM) angiogenesis is critical for tumor growth and recurrence, making it a compelling therapeutic target. Here, a disease-relevant, vascularized tumoroid in vitro model with stem-like features and stromal surrounds is reported.
Externí odkaz:
https://doaj.org/article/2a6e5c25be114acba644f4ae7b071551
Autor:
Oliver Burton, Julie Woodfield, Daniel Richardson, Giles Critchley, Angelos Kolias, Thomas Santarius, Lewis Thorne, Peter Whitfield, Ola Rominiyi, Bharti Kewlani, Harsh Bhatt, Ahmed Ahmed, Michael O’Sullivan, Rasheed Zakaria, Michael D Jenkinson, Gerard Thompson, Paul M Brennan, Rory Piper, Seong Hoon Lee, Neil Barua, Engelbert Mthunzi, Sara Venturini, Daniel M Fountain, Najma Ahmed, Stephen J Price, Colin Watts, Michael T C Poon, Stuart Smith, Anand Pandit, Ryan K Mathew, Soham Bandyopadhyay, Rosa Sun, Setthasorn Zhi Yang Ooi, Victoria Wykes, William Bolton, Abdullah Egiz, Samantha J Mills, Babar Vaqas, Natalie Simon, Puneet Plaha, Georgios Solomou, Aswin Chari, Grainne McKenna, Melissa Gough, Simon Lammy, Sophie T Williams, Isabelle Williams, Andrew J Martin, Sam Hodgson, Robert Spencer, Adam Waldman, Armin Nazari, Joshua Erhabor, Omar Salim, Saad Moughal, Chinedu Brian Egu, Abdurrahman I Islim, Christopher P Millward, Suhaib Abualsaud, Michael Amoo, Neeraj Kalra, Agbolahan Sofela, Thomas C Booth, George E Richardson, Conor S Gillespie, Orla Mantle, Abigail Clynch, Jay J Park, Emily R Bligh, Avani Shanbhag, Moritz Steinruecke, Alvaro Yanez Touzet, Hannah Redpath, Gideon Adegboyega, Prithvi Bahu, Rosaline de Koning, Tomas Ferreira, Dana Hutton, Jashan Selvakumar, Tiffany TS Ye, Ashvin Kuri, Robin Borchert, Bea Duric, Elena Roman, Kristy Kehoe, Jeremy Cheong, Lauren Harris, Mohammad A Mustafa, Hidayatul Abdullmalek, Chinelo Afulukwe, Abdelsalam Nedal Al-Sousi, Yahia Al-Tamimi, Ajitesh Anand, Peter Bodkin, Ion Boiangiu, Abbey Boyle, Christiaan Bredell, Talhah Chaudri, Ana Cios, Iona Cleer, David Coope, Ian Coulter, Harriet Davis, Paolo Jose De Luna, Nayan Dey, Justyna O Ekert, Jinendra Ekanayake, Anna Elso, Tom Flannery, Kwan Wai Fung, Rahul Ganguly, Sanay Goyal, Emily Hardman, Theodore Hirst, Kelvin Sunn Hoah, Kismet Hossain-Ibrahim, Lena Mary Houlihan, Sami Squali Houssaini, Sadid Hoque, Mahnoor Javed, Siddarth Kannan, Efthymia Maria Kapasouri, Andrew Keenlyside, Prerna Khanna, Kunalika Sathish Kumar, Eunkyung Lee, Robert Magouirk, Riccardo Masina, Adele Mazzoleni, Patrick McAleavey, Daniel McSweeney, Trinh Ton Nu Ngoc, Shiva A Nischal, Jonathan Pesic-Smith, Peter Peterson, Isaac Phang, Shyam Pujara, Marwa Mohammed Elrasheed Saad, Shinjan Sangal, Veekshith Shetty, Irtiza Syed, Jesvin Tom Sunny, Anca-Mihaela Vasilica, Daniel O’Flaherty, Arslan Khaliq Raja, Daniele Ramsay, Renitha Reddi, Dorina Roy, Jeremiah Samkutty, Edward Jerome St George, Preethi Subramanian, Vaibhav Sundaresan, Kieron Sweeney, Boon Hoe Tan, Nicole Turnbull, Yuewei Tao, Rebecca Tweedie, Anastasia Tzatzidou, Kathrin Whitehouse, Jack Wildman, Karl Williams, Kelvin Sunn Yap, Mahir Yousuff, Asaad Zulfiqar, Sophie Camp, Setthasorn ZY Ooi
Publikováno v:
BMJ Open, Vol 12, Iss 9 (2022)
Introduction Glioblastoma is the most common malignant primary brain tumour with a median overall survival of 12–15 months (range 6–17 months), even with maximal treatment involving debulking neurosurgery and adjuvant concomitant chemoradiotherap
Externí odkaz:
https://doaj.org/article/ea5706fc5b024e75ade614ef75919d03
Autor:
Amit Patel, Gerard Thompson, Joshua Savage, Rhys Mant, Colin Watts, Olaf Ansorge, Victoria Wykes, Helen Bulbeck, Lucinda Billingham, Adam D Waldman, Rowena Sharpe, Ute Pohl, John Apps
Publikováno v:
BMJ Open, Vol 12, Iss 9 (2022)
Introduction Gliomas are the most common primary tumour of the central nervous system (CNS), with an estimated annual incidence of 6.6 per 100 000 individuals in the USA and around 14 deaths per day from brain tumours in the UK. The genomic and biolo
Externí odkaz:
https://doaj.org/article/4f97b946e2c5402daeff2a9291573e31
Autor:
Ameeta Retzer, Melanie Calvert, Stephanie Sivell, Anthony Byrne, Annmarie Nelson, Robin Grant, Elin Baddeley, Hannah Scott, Kathy Seddon, Colin Watts, Linda Dirven, Richard Adams, Olalekan Lee Aiyegbusi, Samantha Cruz Rivera, Pamela Kearns
Publikováno v:
BMJ Open, Vol 12, Iss 9 (2022)
Introduction Primary brain tumours, specifically gliomas, are a rare disease group. The disease and treatment negatively impacts on patients and those close to them. The high rates of physical and cognitive morbidity differ from other cancers causing
Externí odkaz:
https://doaj.org/article/bac60d7de78c4d93b4cdf448d89ba6d2
Autor:
Michael D Jenkinson, Ashwin Venkatesh, Colin Watts, Michael T C Poon, Victoria Wykes, Stephen John Price, Puneet Plaha, Georgios Solomou, Melissa Gough, Conor S Gillespie, Aref-Ali Gharooni, Waqqas Patel
Publikováno v:
BMJ Open, Vol 12, Iss 7 (2022)
Introduction 5-aminolevulinic acid (5-ALA) is a proagent developed for fluorescent-guided surgery for high-grade glioma patients associated with a significant increase in resection conferring survival. 5-ALA was shown to penetrate the blood–brain b
Externí odkaz:
https://doaj.org/article/3b69d50d45e64d2e8cdcee587b7aa1fc
Autor:
James Snyder, Nisaharan Srikandarajah, Boris Krischek, Matthias Preusser, Michael Weller, Timothy J Kaufmann, Thomas Santarius, Carole Turner, Michael D Cusimano, Paula R Williamson, Michael McDermott, Michael D Jenkinson, Justin Wang, Mohsen Javadpour, Andrea Saladino, Anthony G Marson, David James, Chaya Brodie, Daniel M Fountain, Roland Goldbrunner, Felix Sahm, Sylvia Kurz, Colin Watts, Julian Spears, Amir H Zamanipoor Najafabadi, Simon Walling, Andrew Morokoff, Ghazaleh Tabatabai, Helen Shih, Linda Dirven, Puneet Plaha, Helen Bulbeck, David Schultz, Christian Mawrin, Jens Schittenhelm, Farshad Nassiri, Martin J B Taphoorn, Manfred Westphal, Warren Selman, C Oliver Hanemann, Patrick Y Wen, Mirjam Renovanz, Evanthia Galanis, Alireza Mansouri, Priscilla K Brastianos, Christine Jungk, Heather Barrington, Aaron Cohen-Gadol, Gelareh Zadeh, Abdurrahman I Islim, Christopher P Millward, Theo Georgious, Andrew R Brodbelt, Karolyn Au, Felix Behling, Nicholas Butowski, Ana Castro, Marta Couce, Francesco Dimeco, Craig Erker, Michelle Felicella, Norbert Galldiks, Caterina Giannini, Christel Herold-Mende, Luke Hnenny, Craig Horbinski, Gerhard Jungwirth, Daniel Lachance, Christian Lafougere, Katrin Lamszus, Serge Makarenko, Tathiana Malta, Jennifer Moliterno-Gunel, Houtan Noushmehr, Arie Perry, Aditya Ragunathan, David Raleigh, Franz Ricklefs, Antonio Santacroce, Christian Schichor, Andrew Sloan, Matija Snuderl, Erik Sulman, Suganth Suppiah, Marcos Tatagiba, Marco Timmer, Andreas Von Deimling, Tobias Walbert, Stephen Yip, Gabriel Zada, Viktor Zherebitskiy, Derek Tsang, Kenneth Aldape, Terri S Armstrong, Sabrina Bell, Anna Crofton, Paul L Grundy, Sumirat M Keshwara, Shelli D Koszdin, Michael W McDermott, Torstein R Meling, Kathy Oliver, Jill Barnhartz-Sloan, Wenya Linda Bi, Carlos Carlotti, Katharine Drummond, Ian F Dunn, Brent Griffith, Rintaro Hashizume, Raymond Y Huang, Ian Lee, Jeff C Liu, Yasin Mamatjan, David Munoz, Ho-Keung Ng, Farhad Pirouzmand, Laila M Poisson, Bianca Pollo, Nils O Schmidt, Daniela Tirapelli, Joerg C Tonn, Michael A Vogelbaum, Adriana M Workewych
Publikováno v:
BMJ Open, Vol 12, Iss 5 (2022)
Introduction Meningioma is the most common primary intracranial tumour in adults. The majority are non-malignant, but a proportion behave more aggressively. Incidental/minimally symptomatic meningioma are often managed by serial imaging. Symptomatic
Externí odkaz:
https://doaj.org/article/e6f0561f8df642f8988cb2020bf5eb8a