Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Colin, Kovacs"'
Autor:
Minh Ha Ngo, Joshua Pankrac, Ryan C. Y. Ho, Emmanuel Ndashimye, Rahul Pawa, Renata Ceccacci, Tsigereda Biru, Abayomi S. Olabode, Katja Klein, Yue Li, Colin Kovacs, Robert Assad, Jeffrey M. Jacobson, David H. Canaday, Stephen Tomusange, Samiri Jamiru, Aggrey Anok, Taddeo Kityamuweesi, Paul Buule, Ronald M. Galiwango, Steven J. Reynolds, Thomas C. Quinn, Andrew D. Redd, Jessica L. Prodger, Jamie F. S. Mann, Eric J. Arts
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
ABSTRACTTo date, an affordable, effective treatment for an HIV-1 cure remains only a concept with most “latency reversal” agents (LRAs) lacking specificity for the latent HIV-1 reservoir and failing in early clinical trials. We assessed HIV-1 lat
Externí odkaz:
https://doaj.org/article/c4e48e2d64a24cd4aecbe0e0f13130b6
Autor:
Cecilia T. Costiniuk, Terry Lee, Joel Singer, Yannick Galipeau, Corey Arnold, Marc-André Langlois, Judy Needham, Mohammad-Ali Jenabian, Ann N. Burchell, Hasina Samji, Catharine Chambers, Sharon Walmsley, Mario Ostrowski, Colin Kovacs, Darrell H. S. Tan, Marianne Harris, Mark Hull, Zabrina L. Brumme, Hope R. Lapointe, Mark A. Brockman, Shari Margolese, Enrico Mandarino, Suzanne Samarani, Bertrand Lebouché, Jonathan B. Angel, Jean-Pierre Routy, Curtis L. Cooper, Aslam H. Anis
Publikováno v:
Vaccines, Vol 12, Iss 5, p 447 (2024)
COVID-19 breakthrough infection (BTI) can occur despite vaccination. Using a multi-centre, prospective, observational Canadian cohort of people with HIV (PWH) receiving ≥2 COVID-19 vaccines, we compared the SARS-CoV-2 spike (S) and receptor-binding
Externí odkaz:
https://doaj.org/article/8f124ad3fbae481bb8a48561cba0477a
Autor:
Vitaliy A. Matveev, Erik Z. Mihelic, Erika Benko, Patrick Budylowski, Sebastian Grocott, Terry Lee, Chapin S. Korosec, Karen Colwill, Henry Stephenson, Ryan Law, Lesley A. Ward, Salma Sheikh-Mohamed, Geneviève Mailhot, Melanie Delgado-Brand, Adrian Pasculescu, Jenny H. Wang, Freda Qi, Tulunay Tursun, Lela Kardava, Serena Chau, Philip Samaan, Annam Imran, Dennis C. Copertino, Jr., Gary Chao, Yoojin Choi, Robert J. Reinhard, Rupert Kaul, Jane M. Heffernan, R. Brad Jones, Tae-Wook Chun, Susan Moir, Joel Singer, Jennifer Gommerman, Anne-Claude Gingras, Colin Kovacs, Mario Ostrowski
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107915- (2023)
Summary: Older individuals and people with HIV (PWH) were prioritized for COVID-19 vaccination, yet comprehensive studies of the immunogenicity of these vaccines and their effects on HIV reservoirs are not available. Our study on 68 PWH and 23 HIV-ne
Externí odkaz:
https://doaj.org/article/c0a02cfb1ee4418788ae8efa6e553405
Autor:
Natalie F. McMyn, Joseph Varriale, Emily J. Fray, Carolin Zitzmann, Hannah MacLeod, Jun Lai, Anushka Singhal, Milica Moskovljevic, Mauro A. Garcia, Brianna M. Lopez, Vivek Hariharan, Kyle Rhodehouse, Kenneth Lynn, Pablo Tebas, Karam Mounzer, Luis J. Montaner, Erika Benko, Colin Kovacs, Rebecca Hoh, Francesco R. Simonetti, Gregory M. Laird, Steven G. Deeks, Ruy M. Ribeiro, Alan S. Perelson, Robert F. Siliciano, Janet M. Siliciano
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 17 (2023)
HIV-1 persists in a latent reservoir in resting CD4+ T cells despite antiretroviral therapy (ART). The reservoir decays slowly over the first 7 years of ART (t1/2 = 44 months). However, whether decay continues with long-term ART is unclear. Recent in
Externí odkaz:
https://doaj.org/article/16cb14484f3b4a688aeb5fd64cf309ef
Autor:
Dennis C. Copertino Jr., Carissa S. Holmberg, Jared Weiler, Adam R. Ward, J. Natalie Howard, Callie Levinger, Alina P.S. Pang, Michael J. Corley, Friederike Dündar, Paul Zumbo, Doron Betel, Rajesh T. Gandhi, Deborah K. McMahon, Ronald J. Bosch, Noemi Linden, Bernard J. Macatangay, Joshua C. Cyktor, Joseph J. Eron, John W. Mellors, Colin Kovacs, Erika Benko, Alberto Bosque, R. Brad Jones, for the AIDS Clinical Trials Group (ACTG) A5321 Team
Publikováno v:
JCI Insight, Vol 8, Iss 18 (2023)
IL-15 is under clinical investigation toward the goal of curing HIV infection because of its abilities to reverse HIV latency and enhance immune effector function. However, increased potency through combination with other agents may be needed. 3-Hydr
Externí odkaz:
https://doaj.org/article/ed18029fbf2043e591567763be3f9138
Autor:
Natalie N. Kinloch, Yanqin Ren, Winiffer D. Conce Alberto, Winnie Dong, Pragya Khadka, Szu Han Huang, Talia M. Mota, Andrew Wilson, Aniqa Shahid, Don Kirkby, Marianne Harris, Colin Kovacs, Erika Benko, Mario A. Ostrowski, Perla M. Del Rio Estrada, Avery Wimpelberg, Christopher Cannon, W. David Hardy, Lynsay MacLaren, Harris Goldstein, Chanson J. Brumme, Guinevere Q. Lee, Rebecca M. Lynch, Zabrina L. Brumme, R. Brad Jones
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
The intact proviral DNA assay quantifies the genomically intact HIV reservoir, but assay failure due to HIV-1 polymorphism has been observed. Here, the authors report a 28% failure rate in a cohort of people with HIV-1, and note within-host HIV-1 div
Externí odkaz:
https://doaj.org/article/2f1b4a3b13f745078fbaecf15223c1ef
Autor:
Andrew Wilson, Leyn Shakhtour, Adam Ward, Yanqin Ren, Melina Recarey, Eva Stevenson, Maria Korom, Colin Kovacs, Erika Benko, R. Brad Jones, Rebecca M. Lynch
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Although antiretroviral therapy (ART) successfully suppresses HIV-1 replication, ART-treated individuals must maintain therapy to avoid rebound from an integrated viral reservoir. Strategies to limit or clear this reservoir are urgently needed. Indiv
Externí odkaz:
https://doaj.org/article/cb3a33d59886497f942ad411a9a3afad
Autor:
Cecilia T. Costiniuk, Joel Singer, Terry Lee, Marc-André Langlois, Corey Arnold, Yannick Galipeau, Judy Needham, Iva Kulic, Mohammad-Ali Jenabian, Ann N. Burchell, Hasina Shamji, Catharine Chambers, Sharon Walmsley, Mario Ostrowski, Colin Kovacs, Darrell H.S. Tan, Marianne Harris, Mark Hull, Zabrina L. Brumme, Hope R. Lapointe, Mark A. Brockman, Shari Margolese, Enrico Mandarino, Suzanne Samarani, Branka Vulesevic, Bertrand Lebouché, Jonathan B. Angel, Jean-Pierre Routy, Curtis L. Cooper, Aslam H. Anis
Publikováno v:
AIDS. 37:F1-F10
Many vaccines require higher/additional doses or adjuvants to provide adequate protection for people with HIV (PWH). Our objective was to compare COVID-19 vaccine immunogenicity in PWH to HIV-negative individuals.In a Canadian multi-center prospectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1715cf94f4e93da770103c60d5f8ac35
https://doi.org/10.1097/qad.0000000000003429
https://doi.org/10.1097/qad.0000000000003429
Autor:
David Lessard, Karine Dubé, Martin Bilodeau, Patrick Keeler, Shari Margolese, Ron Rosenes, Liliya Sinyavskaya, Madeleine Durand, Erika Benko, Colin Kovacs, Charlotte Guerlotté, Wangari Tharao, Keresa Arnold, Renée Masching, Darien Taylor, José Sousa, Mario Ostrowski, Jeff Taylor, Andy Kaytes, Davey Smith, Sara Gianella, Nicolas Chomont, Jonathan B. Angel, Jean-Pierre Routy, Éric A. Cohen, Bertrand Lebouché, Cecilia T. Costiniuk
Publikováno v:
AIDS research and human retroviruses, vol 38, iss 8
HIV cure research requires interrogating latent HIV reservoirs in deep tissues, which necessitates autopsies to avoid risks to participants. An HIV autopsy biobank would facilitate this research, but such research raises ethical issues and requires p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d4aaf894ebc2e8175ddd71bb74ed5f
https://pubmed.ncbi.nlm.nih.gov/35778845
https://pubmed.ncbi.nlm.nih.gov/35778845
Autor:
Madeleine Durand, Carl Chartrand-Lefebvre, Jean-Guy Baril, Sylvie Trottier, Benoit Trottier, Marianne Harris, Sharon Walmsley, Brian Conway, Alexander Wong, Jean-Pierre Routy, Colin Kovacs, Paul A. MacPherson, Kenneth Marc Monteith, Samer Mansour, George Thanassoulis, Michal Abrahamowicz, Zhitong Zhu, Christos Tsoukas, Petronela Ancuta, Nicole Bernard, Cécile L. Tremblay, For the investigators of the Canadian HIV and Aging Cohort Study
Publikováno v:
BMC Infectious Diseases, Vol 17, Iss 1, Pp 1-10 (2017)
Abstract Background With potent antiretroviral drugs, HIV infection is becoming a chronic disease. Emergence of comorbidities, particularly cardiovascular disease (CVD) has become a leading concern for patients living with the infection. We hypothesi
Externí odkaz:
https://doaj.org/article/218a9b2d7a1248afbef0b30ecc7436d6