Rationale and design of the BeyeOMARKER study: prospective evaluation of blood- and eye-based biomarkers for early detection of Alzheimer’s disease pathology in the eye clinic

Autor: Ilse Bader, Colin Groot, H. Stevie Tan, Jean-Marie A. Milongo, Jurre den Haan, Inge M. W. Verberk, Keir Yong, Julie Orellina, Shannon Campbell, David Wilson, Argonde C. van Harten, Pauline H. B. Kok, Wiesje M. van der Flier, Yolande A. L. Pijnenburg, Frederik Barkhof, Elsmarieke van de Giessen, Charlotte E. Teunissen, Femke H. Bouwman, Rik Ossenkoppele

Publikováno v: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-18 (2024)

Abstract Background Alzheimer’s disease (AD) is a common, complex and multifactorial disease that may require screening across multiple routes of referral to enable early detection and subsequent future implementation of tailored interventions. Blo

Externí odkaz: https://doaj.org/article/80e39a0fdb1b42279ca2d571671cea81

Mesial temporal tau in amyloid-β-negative cognitively normal older persons

Autor: Natasha Krishnadas, Vincent Doré, Colin Groot, Fiona Lamb, Pierrick Bourgeat, Samantha C. Burnham, Kun Huang, Anita M. Y. Goh, Colin L. Masters, Victor L. Villemagne, Christopher C. Rowe, for the AIBL research group

Publikováno v: Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-10 (2022)

Abstract Background Tau deposition in the mesial temporal lobe (MTL) in the absence of amyloid-β (Aβ−) occurs with aging. The tau PET tracer 18F-MK6240 has low non-specific background binding so is well suited to exploration of early-stage tau de

Externí odkaz: https://doaj.org/article/29865099cabe401bb295621f4d6488e7

[18F]RO948 tau positron emission tomography in genetic and sporadic frontotemporal dementia syndromes

Autor: Alexander F. Santillo, Antoine Leuzy, Michael Honer, Maria Landqvist Waldö, Pontus Tideman, Luke Harper, Tomas Ohlsson, Svenja Moes, Lucia Giannini, Jonas Jögi, Colin Groot, Rik Ossenkoppele, Olof Strandberg, John van Swieten, Ruben Smith, Oskar Hansson

Publikováno v: Santillo, A F, Leuzy, A, Honer, M, Landqvist Waldö, M, Tideman, P, Harper, L, Ohlsson, T, Moes, S, Giannini, L, Jögi, J, Groot, C, Ossenkoppele, R, Strandberg, O, van Swieten, J, Smith, R & Hansson, O 2022, ' [18F]RO948 tau positron emission tomography in genetic and sporadic frontotemporal dementia syndromes ', European Journal of Nuclear Medicine and Molecular Imaging . https://doi.org/10.1007/s00259-022-06065-4
European Journal of Nuclear Medicine and Molecular Imaging. Springer Verlag
European Journal of Nuclear Medicine and Molecular Imaging, 50(5), 1371-1383. Springer-Verlag

Purpose To examine [18F]RO948 retention in FTD, sampling the underlying protein pathology heterogeneity. Methods A total of 61 individuals with FTD (n = 35), matched cases of AD (n = 13) and Aβ-negative cognitively unimpaired individuals (n = 13) un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3211583246f197264d679de81f03d860
http://www.scopus.com/inward/record.url?scp=85143887800&partnerID=8YFLogxK

Differential trajectories of hypometabolism across cognitively-defined Alzheimer’s disease subgroups

Autor: Colin Groot, Shannon L. Risacher, J.Q. Alida Chen, Ellen Dicks, Andrew J. Saykin, Christine L. Mac Donald, Jesse Mez, Emily H. Trittschuh, Shubhabrata Mukherjee, Frederik Barkhof, Philip Scheltens, Wiesje M. van der Flier, Rik Ossenkoppele, Paul K. Crane

Publikováno v: NeuroImage: Clinical, Vol 31, Iss , Pp 102725- (2021)

Disentangling biologically distinct subgroups of Alzheimer’s disease (AD) may facilitate a deeper understanding of the neurobiology underlying clinical heterogeneity. We employed longitudinal [18F]FDG-PET standardized uptake value ratios (SUVRs) to

Externí odkaz: https://doaj.org/article/f9ff498d9a524fb8bcf59d02bd62f09f

Case Report: 18F-MK6240 Tau Positron Emission Tomography Pattern Resembling Chronic Traumatic Encephalopathy in a Retired Australian Rules Football Player

Autor: Natasha Krishnadas, Vincent Doré, Fiona Lamb, Colin Groot, Paul McCrory, Rodney Guzman, Rachel Mulligan, Kun Huang, Meaghan O'Donnell, Jennie Ponsford, Malcolm Hopwood, Victor L. Villemagne, Christopher C. Rowe

Publikováno v: Frontiers in Neurology, Vol 11 (2020)

Introduction: It remains unclear if tau imaging may assist diagnosis of chronic traumatic encephalopathy (CTE). Flortaucipir PET has shown superior frontal with medial temporal tau binding consistent with the provisional neuropathological criteria fo

Externí odkaz: https://doaj.org/article/12e41b2b82144180ad02dee6432fd152