Výsledky vyhledávání - "Colette J. Rudd"

Genetic toxicology studies in SALATRIM structured triacylglycerols. 2. Lack of genetic damage in in vitro mammalian cell assays and the in vivo micronucleus assay

Autor: Johnnie R. Hayes, Colette J. Rudd, Hemalatha Murli, Jon C. Mirsalis, James Bakke, Richard A. Winegar

Publikováno v: Journal of Agricultural and Food Chemistry. 42:521-527

The SALATRIM family of triacylglycerols differs from other fats in the ratio of short-chain fatty acids (SCFA) to long-chain fatty acids (LCFA) and in that stearic acid is the major LCFA. These fats have caloric availability values (4.5-6 kcal/g) low

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a848d987903ac17f48cc7537403bff71
https://doi.org/10.1021/jf00038a049

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Autor: S.H.H. Swierenga, Colette J. Rudd, E.R. Nestmann, J.P.W. Gilman, R.L. Brillinger

Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 246:255-284

Laboratory protocols and guidelines have been developed for the performance of point mutation assays using Chinese hamster ovary (CHO) cells, V79 cells, and L5178Y mouse lymphoma cells. Since only minor differences in the treatment of CHO and V79 cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e804afbf807b28658572fc36fc649ba9
https://doi.org/10.1016/0027-5107(91)90048-s

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Correlation of the ability of retinoids to inhibit promoter-induced anchorage-independent growth of JB6 mouse epidermal cells with their activation of retinoic acid receptor gamma

Autor: Jonathan N. Mansbridge, Kathryn D. Suing, Colette J. Rudd, Marcia I. Dawson

Publikováno v: Cancer letters. 73(1)

Retinoids inhibit the biological effects induced in mouse epidermal cells by the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA). Specific nuclear retinoic acid receptors (RARs) have been identified in the epidermis, but the specific recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d998d13559065c2655d24012a7b67cfd
https://pubmed.ncbi.nlm.nih.gov/8402597

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Spontaneous mutation rates in mammalian cells: effect of differential growth rates and phenotypic lag

Autor: W J Caspary, D S Daston, Colette J. Rudd

Publikováno v: Genetics. 126(2)

We calculated a spontaneous rate of 26-37 X 10(-6) mutations per cell division for L5178Y MOLY (mouse lymphoma) cells at the thymidine kinase locus (tk(+/-) -> tk(-/-)) using a procedure that isolated and segregated cells during expression. This rate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60cef7f1eab8e43a5a4b75417893e350
https://pubmed.ncbi.nlm.nih.gov/2123164

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Chromosome analysis of trifluorothymidine-resistant L5178y mouse lymphoma cell colonies

Autor: Barbara E. Stewart, Ann D. Mitchell, William J. Caspary, William F. Blazak, Katherine L. Allen, Colette J. Rudd, I. Galperin

Publikováno v: Environmental Mutagenesis. 8:229-240

Cells from small (sigma) and large (lambda) trifluorothymidine-resistant (TFTr) colonies induced by chemical mutagen treatment of TK+/-L5178Y mouse lymphoma cells were examined for chromosomal abnormalities. Analysis of G-banded metaphase chromosomes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76dc0a8cb78ca0e16564091d66a6b510
https://doi.org/10.1002/em.2860080205

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Chromosome analysis of small and large L5178Y mouse lymphoma cell colonies: comparison of trifluorothymidine-resistant and unselected cell colonies from mutagen-treated and control cultures

Autor: Frances J. Los, William F. Blazak, Colette J. Rudd, William J. Caspary

Publikováno v: Mutation Research/Genetic Toxicology. 224:197-208

Mutagenesis assays at the thymidine kinase (TK) locus in L5178Y mouse lymphoma cells frequently yield mutant colonies with a bimodal size distribution. The objectives of this study were to determine whether a relationship exists between mutant colony

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed277157e300cc94848f79d643ad5b29
https://doi.org/10.1016/0165-1218(89)90156-0

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Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: interlaboratory reproducibility and assessment

Autor: William J. Caspary, Pamela S. Lee, Ann D. Mitchell, Brian C. Myhr, Diane S. Daston, Colette J. Rudd

Publikováno v: Environmental and molecular mutagenesis. 12

The L5178Y mouse lymphoma cell mutagenesis assay is used to detect the mutagenic activity of chemicals in a mammalian cell system. To evaluate this assay we compared the results of assays performed independently on 63 chemicals by laboratories at SRI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5803488170e35595920c32b807f2840f
https://pubmed.ncbi.nlm.nih.gov/3416840

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