Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Colette Cywes"'
Publikováno v:
Engineering, Vol 38, Iss , Pp 69-76 (2024)
The β-1–6-linked poly-N-acetylglucosamine (PNAG) polymer is a conserved surface polysaccharide produced by many bacteria, fungi, and protozoan (and even filarial) parasites. This wide-ranging expression makes PNAG an attractive target for vaccine
Externí odkaz:
https://doaj.org/article/9bd7abbf4af44803839564c569aa7c05
Autor:
Zibin Tan, Weizhun Yang, Nicholas A. O’Brien, Xingling Pan, Sherif Ramadan, Terence Marsh, Neal Hammer, Colette Cywes-Bentley, Mariana Vinacur, Gerald B. Pier, Jeffrey C. Gildersleeve, Xuefei Huang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Poly-β-(1–6)-N-acetylglucosamine (PNAG) is an important vaccine target, expressed on many pathogens. A critical hurdle in developing PNAG based vaccine is that the impacts of the number and the position of free amine vs N-acetylation on i
Externí odkaz:
https://doaj.org/article/3bb1198e173a4bd293f55ac76b647033
Autor:
Jeffrey B. Kaplan, Colette Cywes-Bentley, Gerald B. Pier, Nandadeva Yakandawala, Miloslav Sailer, Marc S. Edwards, Khalaf Kridin
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
BackgroundThe commensal skin bacterium Cutibacterium acnes plays a role in the pathogenesis of acne vulgaris and also causes opportunistic infections of implanted medical devices due to its ability to form biofilms on biomaterial surfaces. Poly-β-(1
Externí odkaz:
https://doaj.org/article/0e0d87d754254d9eb46c8776890c89d1
Autor:
Stéphanie Pons, Eric Frapy, Youssouf Sereme, Charlotte Gaultier, François Lebreton, Andrea Kropec, Olga Danilchanka, Laura Schlemmer, Cécile Schrimpf, Margaux Allain, François Angoulvant, Hervé Lecuyer, Stéphane Bonacorsi, Hugues Aschard, Harry Sokol, Colette Cywes-Bentley, John J. Mekalanos, Thomas Guillard, Gerald B. Pier, Damien Roux, David Skurnik
Publikováno v:
EBioMedicine, Vol 88, Iss , Pp 104439- (2023)
Summary: Background: Worldwide, Escherichia coli is the leading cause of neonatal Gram-negative bacterial meningitis, but full understanding of the pathogenesis of this disease is not yet achieved. Moreover, to date, no vaccine is available against b
Externí odkaz:
https://doaj.org/article/6072e4ffadcf4741b891307baa3891fb
Autor:
Susanne K. Kahn, Colette Cywes‐Bentley, Glenn P. Blodgett, Nathan M. Canaday, Carly E. Turner‐Garcia, Patricia Flores‐Ahlschwede, Laurie L. Metcalfe, Mark Nevill, Mariana Vinacur, Patrick J. Sutter, Sarah C. Meyer, Angela I. Bordin, Gerald B. Pier, Noah D. Cohen
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 35, Iss 6, Pp 2912-2919 (2021)
Abstract Background Hyperimmune plasma raised against β‐1→6‐poly‐N‐acetyl glucosamine (PNAG HIP) mediates more opsonophagocytic killing of Rhodococcus equi (R equi) than does R equi hyperimmune plasma (RE HIP) in vitro. The relative effica
Externí odkaz:
https://doaj.org/article/b8a0a336180c4bb5b0edefd34d91526c
Autor:
Noah D. Cohen, Susanne K. Kahn, Colette Cywes-Bentley, Sophia Ramirez-Cortez, Amanda E. Schuckert, Mariana Vinacur, Angela I. Bordin, Gerald B. Pier
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 1 (2021)
ABSTRACT Rhodococcus equi is a prevalent cause of pneumonia in foals worldwide. Our laboratory has demonstrated that vaccination against the surface polysaccharide β-1→6-poly-N-acetylglucosamine (PNAG) protects foals against intrabronchial infecti
Externí odkaz:
https://doaj.org/article/24151ab2c0c54e9aa0962aadf2c8117f
Autor:
Chelsea N. Folmar, Colette Cywes‐Bentley, Angela I. Bordin, Joana N. Rocha, Jocelyne M. Bray, Susanne K. Kahn, Amanda E. Schuckert, Gerald B. Pier, Noah D. Cohen
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 33, Iss 3, Pp 1493-1499 (2019)
Abstract Background The bacterium Rhodococcus equi can cause severe pneumonia in foals. The absence of a licensed vaccine and limited effectiveness of commercial R. equi hyperimmune plasma (RE‐HIP) create a great need for improved prevention of thi
Externí odkaz:
https://doaj.org/article/f3ac190ff0814b678ab69e3780d25b1d
Autor:
Susanne K Kahn, Colette Cywes-Bentley, Glenn P Blodgett, Nathan M Canaday, Carly E Turner-Garcia, Mariana Vinacur, Sophia C Cortez-Ramirez, Patrick J Sutter, Sarah C Meyer, Angela I Bordin, Daniel R Vlock, Gerald B Pier, Noah D Cohen
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0250133 (2021)
The efficacy of transfusion with hyperimmune plasma (HIP) for preventing pneumonia caused by Rhodococcus equi remains ill-defined. Quarter Horse foals at 2 large breeding farms were randomly assigned to be transfused with 2 L of HIP from adult donors
Externí odkaz:
https://doaj.org/article/5c9f5f033fbe46f0bf40e651dc78a441
Autor:
Noah D Cohen, Colette Cywes-Bentley, Susanne M Kahn, Angela I Bordin, Jocelyne M Bray, S Garrett Wehmeyer, Gerald B Pier
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240479 (2020)
Strangles is a common disease of horses with worldwide distribution caused by the bacterium Streptococcus equi subspecies equi (SEE). Although vaccines against strangles are available commercially, these products have limitations in safety and effica
Externí odkaz:
https://doaj.org/article/855b8179b5d24b3b90dd2598ce073baa
Autor:
Naomi S. Taus, Colette Cywes-Bentley, Wendell C. Johnson, Gerald B. Pier, Lindsay M. Fry, Michelle R. Mousel, Massaro W. Ueti
Publikováno v:
Pathogens, Vol 10, Iss 12, p 1598 (2021)
Arthropod-borne apicomplexan pathogens remain a great concern and challenge for disease control in animals and humans. In order to prevent Babesia infection, the discovery of antigens that elicit protective immunity is essential to establish approach
Externí odkaz:
https://doaj.org/article/7080650b99bf460f95bcd950f96798b7