Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Colene Drace"'
Autor:
Abdelmoula Namil, Mark R. Hellberg, Andrew Rusinko, Bryon S. Severns, Jennifer Ward, Colene Drace, Iok-Hou Pang, Shenouda Yacoub, Keith D. Combrink, Curtis R. Kelly, Byron Li, Marsha A. McLaughlin, Raj Patil, N.A. Sharif, Hwang Hsing Chen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:1875-1879
A series of 2,3,6-pyrazine Rho Kinase inhibitors were optimized for in vivo activity for topical ocular dosing. Modifications of the 2-(piperazin-1-yl)pyrazine derivatives produced compounds with improved solubility and physicochemical properties. Mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d182bc1267668fdba6283e228caac75f
https://doi.org/10.1016/j.bmcl.2014.03.017
https://doi.org/10.1016/j.bmcl.2014.03.017
Autor:
Mark R. Hellberg, Colene Drace, Mark Hadden, Raj Patil, Marsha A. McLaughlin, Andrew Rusinko, Cheng Guo, Alan J. Henderson, N.A. Sharif, Decornez Helene, Neema Douglas
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1137-1140
Inhibition of rho kinase (ROCK) has been recognized as an important target for a number of diseases, including glaucoma. Herein we report SAR development around two hits from a kinase library that led to the discovery of the ROCK inhibitor compound 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbb48a6520b9d4028267e693f42a6168
https://doi.org/10.1016/j.bmcl.2009.12.012
https://doi.org/10.1016/j.bmcl.2009.12.012