The RNA binding protein Arid5a drives IL-17-dependent autoantibody-induced glomerulonephritis.

Autor: Li Y; Division of Rheumatology & Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Vyas SP; Division of Rheumatology & Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Mehta I; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA., Asada N; III Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf , Hamburg, Germany., Dey I; Division of Rheumatology & Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Taylor TC; Division of Rheumatology & Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Bechara R; Division of Rheumatology & Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Amatya N; Division of Rheumatology & Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Aggor FEY; Division of Rheumatology & Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Coleman BM; Division of Rheumatology & Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Li DD; Division of Rheumatology & Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Yamamoto K; Division of Rheumatology & Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Ezenwa O; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA., Sun Y; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA., Sterneck E; Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA., McManus CJ; Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, USA., Panzer U; III Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf , Hamburg, Germany., Biswas PS; Division of Rheumatology & Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Savan R; Department of Immunology, School of Medicine, University of Washington, Seattle, WA, USA., Das J; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA., Gaffen SL; Division of Rheumatology & Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2024 Sep 02; Vol. 221 (9). Date of Electronic Publication: 2024 Jul 26.

Expansion of extrafollicular B and T cell subsets in childhood-onset systemic lupus erythematosus.

Autor: Baxter RM; Department of Immunology and Microbiology, School of Medicine, University of Colorado, Aurora, CO, United States., Wang CS; Department of Pediatrics, Section of Rheumatology, School of Medicine, University of Colorado, Children's Hospital Colorado, Aurora, CO, United States., Garcia-Perez JE; Department of Immunology and Microbiology, School of Medicine, University of Colorado, Aurora, CO, United States., Kong DS; Department of Immunology and Microbiology, School of Medicine, University of Colorado, Aurora, CO, United States., Coleman BM; Department of Immunology and Microbiology, School of Medicine, University of Colorado, Aurora, CO, United States., Larchenko V; Department of Immunology and Microbiology, School of Medicine, University of Colorado, Aurora, CO, United States., Schuyler RP; Department of Immunology and Microbiology, School of Medicine, University of Colorado, Aurora, CO, United States., Jackson C; Center for Innovative Design and Analysis, School of Public Health, University of Colorado, Aurora, CO, United States., Ghosh T; Department of Biostatistics and Informatics, School of Public Health, University of Colorado, Aurora, CO, United States., Rudra P; Department of Statistics, Oklahoma State University, Stillwater, OK, United States., Paul D; Clinical Bioinformatics & Machine Learning in Translational Single-Cell Biology, University of Tuebingen, Tuebingen, Germany., Claassen M; Clinical Bioinformatics & Machine Learning in Translational Single-Cell Biology, University of Tuebingen, Tuebingen, Germany., Rochford R; Department of Immunology and Microbiology, School of Medicine, University of Colorado, Aurora, CO, United States., Cambier JC; Department of Immunology and Microbiology, School of Medicine, University of Colorado, Aurora, CO, United States., Ghosh D; Department of Biostatistics and Informatics, School of Public Health, University of Colorado, Aurora, CO, United States., Cooper JC; Department of Pediatrics, Section of Rheumatology, School of Medicine, University of Colorado, Children's Hospital Colorado, Aurora, CO, United States., Smith MJ; Department of Immunology and Microbiology, School of Medicine, University of Colorado, Aurora, CO, United States.; Department of Pediatrics, Barbara Davis Center for Diabetes, School of Medicine, University of Colorado, Aurora, CO, United States., Hsieh EWY; Department of Immunology and Microbiology, School of Medicine, University of Colorado, Aurora, CO, United States.; Department of Pediatrics, Section of Allergy and Immunology, School of Medicine, University of Colorado, Children's Hospital Colorado, Aurora, CO, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2023 Oct 27; Vol. 14, pp. 1208282. Date of Electronic Publication: 2023 Oct 27 (Print Publication: 2023).

The Candida albicans toxin candidalysin mediates distinct epithelial inflammatory responses through p38 and EGFR-ERK pathways.

Autor: Nikou SA; Protein Phosphorylation Laboratory, Francis Crick Institute, London, UK.; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London, UK., Zhou C; Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA., Griffiths JS; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London, UK., Kotowicz NK; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London, UK., Coleman BM; Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA., Green MJ; Experimental Histopathology Laboratory, Francis Crick Institute, London, UK., Moyes DL; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London, UK., Gaffen SL; Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA., Naglik JR; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London, UK., Parker PJ; Protein Phosphorylation Laboratory, Francis Crick Institute, London, UK.; School of Cancer and Pharmaceutical Sciences, New Hunt's House, King's College London, London, UK.

Publikováno v: Science signaling [Sci Signal] 2022 Apr 05; Vol. 15 (728), pp. eabj6915. Date of Electronic Publication: 2022 Apr 05.

The m ⁶ A reader IMP2 directs autoimmune inflammation through an IL-17- and TNFα-dependent C/EBP transcription factor axis.

Autor: Bechara R; Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA., Amatya N; Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA., Bailey RD; Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA., Li Y; Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA., Aggor FEY; Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA., Li DD; Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA., Jawale CV; Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA., Coleman BM; Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA., Dai N; Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA., Gokhale NS; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA., Taylor TC; Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA., Horner SM; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.; Department of Medicine, Duke University Medical Center, Durham, NC, USA., Poholek AC; Division of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA., Bansal A; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA., Biswas PS; Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA., Gaffen SL; Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA. sarah.gaffen@pitt.edu.

Publikováno v: Science immunology [Sci Immunol] 2021 Jul 02; Vol. 6 (61).

Restoring glucose uptake rescues neutrophil dysfunction and protects against systemic fungal infection in mouse models of kidney disease.

Autor: Jawale CV; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA., Ramani K; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA., Li DD; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA., Coleman BM; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA., Oberoi RS; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA., Kupul S; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA., Lin L; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA., Desai JV; Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20814, USA., Delgoffe GM; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA., Lionakis MS; Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20814, USA., Bender FH; Division of Renal-Electrolyte, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA., Prokopienko AJ; Department of Pharmacy and Therapeutics, University of Pittsburgh, Pittsburgh, PA 15261, USA., Nolin TD; Division of Renal-Electrolyte, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Department of Pharmacy and Therapeutics, University of Pittsburgh, Pittsburgh, PA 15261, USA., Gaffen SL; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA., Biswas PS; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA. psb13@pitt.edu.

Publikováno v: Science translational medicine [Sci Transl Med] 2020 Jun 17; Vol. 12 (548).