Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Coleen T Murphy"'
Publikováno v:
eLife, Vol 13 (2024)
Cognitive decline is a significant health concern in our aging society. Here, we used the model organism C. elegans to investigate the impact of the IIS/FOXO pathway on age-related cognitive decline. The daf-2 Insulin/IGF-1 receptor mutant exhibits a
Externí odkaz:
https://doaj.org/article/c036c258dbf64fbfb22dffad196fb5d2
Autor:
Titas Sengupta, Jonathan St Ange, Rachel Kaletsky, Rebecca S Moore, Renee J Seto, Jacob Marogi, Cameron Myhrvold, Zemer Gitai, Coleen T Murphy
Publikováno v:
PLoS Genetics, Vol 20, Iss 3, p e1011178 (2024)
C. elegans can learn to avoid pathogenic bacteria through several mechanisms, including bacterial small RNA-induced learned avoidance behavior, which can be inherited transgenerationally. Previously, we discovered that a small RNA from a clinical iso
Externí odkaz:
https://doaj.org/article/0c811e04461f4c61a5bca97ae8cd9a63
Autor:
Coleen T Murphy
Publikováno v:
PLoS Biology, Vol 21, Iss 5, p e3002132 (2023)
Breakthroughs in the longevity field over the past few decades have led to major shifts in how we attack the problem of aging. What have been the most important of these shifts in our perspectives, aims, and approaches that will likely guide future r
Externí odkaz:
https://doaj.org/article/a1efbaec37344b28ac0080401e6b1fe6
Publikováno v:
PLoS Genetics, Vol 18, Iss 9, p e1010400 (2022)
Women's reproductive cessation is the earliest sign of human aging and is caused by decreasing oocyte quality. Similarly, C. elegans' reproduction declines in mid-adulthood and is caused by oocyte quality decline. Aberrant mitochondrial morphology is
Externí odkaz:
https://doaj.org/article/716cda4aac86437e999922ac76b5ac07
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 10 (2021)
Abstract Caenorhabditis elegansC. elegansCeC. elegans
Externí odkaz:
https://doaj.org/article/67346badbb864bf1963d197aec34a957
Autor:
Coleen T Murphy
Publikováno v:
eLife, Vol 9 (2020)
A truncated version of the only insulin receptor in C. elegans has been discovered.
Externí odkaz:
https://doaj.org/article/4804fb9f9caa47038c509a94b7255039
Publikováno v:
eLife, Vol 8 (2019)
Lifespan is shortened by mating, but these deleterious effects must be delayed long enough for successful reproduction. Susceptibility to brief mating-induced death is caused by the loss of protection upon self-sperm depletion. Self-sperm maintains t
Externí odkaz:
https://doaj.org/article/0b5d8fbf6c1e482b836e06657977105a
Autor:
Rachel Kaletsky, Victoria Yao, April Williams, Alexi M Runnels, Alicja Tadych, Shiyi Zhou, Olga G Troyanskaya, Coleen T Murphy
Publikováno v:
PLoS Genetics, Vol 14, Iss 8, p e1007559 (2018)
The biology and behavior of adults differ substantially from those of developing animals, and cell-specific information is critical for deciphering the biology of multicellular animals. Thus, adult tissue-specific transcriptomic data are critical for
Externí odkaz:
https://doaj.org/article/ef018f0f09e5443c86c14b693df8f4c4
Publikováno v:
eLife, Vol 6 (2017)
Differences in longevity between sexes is a mysterious yet general phenomenon across great evolutionary distances. To test the roles of responses to environmental cues and sexual behaviors in longevity regulation, we examined Caenorhabditis male life
Externí odkaz:
https://doaj.org/article/33f3940d5d0e4ae08b8c051226655203
Autor:
Diana Andrea Fernandes de Abreu, Antonio Caballero, Pascal Fardel, Nicholas Stroustrup, Zhunan Chen, Kyunghwa Lee, William D Keyes, Zachary M Nash, Isaac F López-Moyado, Federico Vaggi, Astrid Cornils, Martin Regenass, Anca Neagu, Ivan Ostojic, Chang Liu, Yongmin Cho, Deniz Sifoglu, Yu Shen, Walter Fontana, Hang Lu, Attila Csikasz-Nagy, Coleen T Murphy, Adam Antebi, Eric Blanc, Javier Apfeld, Yun Zhang, Joy Alcedo, Queelim Ch'ng
Publikováno v:
PLoS Genetics, Vol 10, Iss 3, p e1004225 (2014)
Insulin-like peptides (ILPs) play highly conserved roles in development and physiology. Most animal genomes encode multiple ILPs. Here we identify mechanisms for how the forty Caenorhabditis elegans ILPs coordinate diverse processes, including develo
Externí odkaz:
https://doaj.org/article/f2bbc108c2fa40b6adeeb728934d9508