Zobrazeno 1 - 10
of 227
pro vyhledávání: '"Coleen T Murphy"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Detecting chemical signals is important for identifying food sources and avoiding harmful agents. Like many animals, C. elegans use olfaction to chemotax towards their main food source, bacteria. However, little is known about the bacterial
Externí odkaz:
https://doaj.org/article/bc0f403bbf824a008b0a7570096d1dd0
Publikováno v:
eLife, Vol 13 (2024)
Cognitive decline is a significant health concern in our aging society. Here, we used the model organism C. elegans to investigate the impact of the IIS/FOXO pathway on age-related cognitive decline. The daf-2 Insulin/IGF-1 receptor mutant exhibits a
Externí odkaz:
https://doaj.org/article/c036c258dbf64fbfb22dffad196fb5d2
Autor:
Yifei Weng, Coleen T. Murphy
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109910- (2024)
Summary: Aging is a complex biological process with sexually dimorphic aspects. Although cognitive aging of Caenorhabditis elegans hermaphrodites has been studied, less is known about cognitive decline in males. We found that cognitive aging has both
Externí odkaz:
https://doaj.org/article/bd73d77cfd184178a63602d1f2cbf2c8
Autor:
Titas Sengupta, Jonathan St Ange, Rachel Kaletsky, Rebecca S Moore, Renee J Seto, Jacob Marogi, Cameron Myhrvold, Zemer Gitai, Coleen T Murphy
Publikováno v:
PLoS Genetics, Vol 20, Iss 3, p e1011178 (2024)
C. elegans can learn to avoid pathogenic bacteria through several mechanisms, including bacterial small RNA-induced learned avoidance behavior, which can be inherited transgenerationally. Previously, we discovered that a small RNA from a clinical iso
Externí odkaz:
https://doaj.org/article/0c811e04461f4c61a5bca97ae8cd9a63
Autor:
Morgan E. Stevenson, Gregor Bieri, Rachel Kaletsky, Jonathan St. Ange, L. Remesal, Karishma J.B. Pratt, Shiyi Zhou, Yifei Weng, Coleen T. Murphy, Saul A. Villeda
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113151- (2023)
Summary: Loss of cognitive function with age is devastating. EGL-30/GNAQ and Gαq signaling pathways are highly conserved between C. elegans and mammals, and murine Gnaq is enriched in hippocampal neurons and declines with age. We found that activati
Externí odkaz:
https://doaj.org/article/2af01ce5e4ec4d6f9e14fe63f86a506a
Autor:
Coleen T Murphy
Publikováno v:
PLoS Biology, Vol 21, Iss 5, p e3002132 (2023)
Breakthroughs in the longevity field over the past few decades have led to major shifts in how we attack the problem of aging. What have been the most important of these shifts in our perspectives, aims, and approaches that will likely guide future r
Externí odkaz:
https://doaj.org/article/a1efbaec37344b28ac0080401e6b1fe6
Akademický článek
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Autor:
Lauren M. McIntyre, Francisco Huertas, Alison M. Morse, Rachel Kaletsky, Coleen T. Murphy, Vrinda Kalia, Gary W. Miller, Olexander Moskalenko, Ana Conesa, Danielle E. Mor
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Parkinson’s disease (PD) is a disabling neurodegenerative disorder in which multiple cell types, including dopaminergic and cholinergic neurons, are affected. The mechanisms of neurodegeneration in PD are not fully understood, limiting the
Externí odkaz:
https://doaj.org/article/7b6b9565a6ca4caa885a23452e6ff4cd
Publikováno v:
PLoS Genetics, Vol 18, Iss 9, p e1010400 (2022)
Women's reproductive cessation is the earliest sign of human aging and is caused by decreasing oocyte quality. Similarly, C. elegans' reproduction declines in mid-adulthood and is caused by oocyte quality decline. Aberrant mitochondrial morphology is
Externí odkaz:
https://doaj.org/article/716cda4aac86437e999922ac76b5ac07
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Salman Sohrabi et al. develop an automated, high-throughput assay to study spasm-like curling behavior in C. elegans, which is related to motor control symptoms in Parkinson’s disease. They apply this screening approach to identify four candidate d
Externí odkaz:
https://doaj.org/article/74da37c3af4d4181ad273528c6947316