Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Cole Tolledo"'
Publikováno v:
Mol Neurobiol
CYP2D metabolizes many drugs that act within the brain, and variable expression of CYP2D in the brain may alter local drug and metabolite levels sufficiently to affect behavioral responses. Transgenic mice that express human CYP2D6 (TG) were compared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b99adeb80592223f6339b7cd09ca5b7
https://doi.org/10.1007/s12035-020-01896-4
https://doi.org/10.1007/s12035-020-01896-4
Autor:
Marlaina R. Stocco, Frank J. Gonzalez, Sharon Miksys, Cole Tolledo, Rachel F. Tyndale, Fariba Baghai Wadji
Publikováno v:
Mol Neurobiol
CYP2D6 metabolically inactivates several neurotoxins, including beta-carbolines, which are implicated in neurodegenerative diseases. Variation in CYP2D6 within the brain may alter local inactivation of neurotoxic beta-carbolines, thereby influencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944d1d52761a7039c8e0a0d063c64983
https://europepmc.org/articles/PMC8865091/
https://europepmc.org/articles/PMC8865091/
Autor:
José N. Nobrega, Rachel F. Tyndale, Gary Remington, Sharon Miksys, Edgor Cole Tolledo, Fariba Baghai Wadji
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 78:140-148
Risk for side-effects after acute (e.g. parkinsonism) or chronic (e.g. tardive dyskinesia) treatment with antipsychotics, including haloperidol, varies substantially among people. CYP2D can metabolize many antipsychotics and variable brain CYP2D meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceed668ef2620a6466eccb3b8e476d26
https://doi.org/10.1016/j.pnpbp.2017.04.030
https://doi.org/10.1016/j.pnpbp.2017.04.030
Publikováno v:
Br J Pharmacol
Background and purpose Genetics and drug interactions contribute to large interindividual variation in human CYP2D6 activity. Here, we have characterized propranolol inhibition of human and mouse CYP2D using transgenic (TG) mice, which express both m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::752f60bc5e21fd97dce6ad110bf4dbb7
https://pubmed.ncbi.nlm.nih.gov/31648367
https://pubmed.ncbi.nlm.nih.gov/31648367
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 69:1-10
Repeated exposure to sub-anesthetic doses of ketamine in rats has been shown to induce cognitive deficits, as well as behavioral changes akin to the negative symptoms of schizophrenia, giving much face validity to the use of ketamine administration a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7444418893389de431728f49be75ddc6
https://doi.org/10.1016/j.pnpbp.2016.03.007
https://doi.org/10.1016/j.pnpbp.2016.03.007
Publikováno v:
European Neuropsychopharmacology. 26:S237-S238
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c62d7dc8ecf1d511718be896cd045dd
https://doi.org/10.1016/s0924-977x(16)31102-6
https://doi.org/10.1016/s0924-977x(16)31102-6