Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Cole TR"'
Autor:
David F. Read, Gregory T. Booth, Riza M. Daza, Dana L. Jackson, Rula Green Gladden, Sanjay R. Srivatsan, Brent Ewing, Jennifer M. Franks, Cailyn H. Spurrell, Anne Roshella Gomes, Diana O’Day, Aishwarya A. Gogate, Beth K. Martin, Haleigh Larson, Christian Pfleger, Lea Starita, Yiing Lin, Jay Shendure, Shin Lin, Cole Trapnell
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Sex differences and age-related changes in the human heart at the tissue, cell, and molecular level have been well-documented and many may be relevant for cardiovascular disease. However, how molecular programs within individual cell types v
Externí odkaz:
https://doaj.org/article/c78d59de759c46328c8bc8b520ab680e
Autor:
Gregory T. Booth, Riza M. Daza, Sanjay R. Srivatsan, José L. McFaline-Figueroa, Rula Green Gladden, Andrew C. Mullen, Scott N. Furlan, Jay Shendure, Cole Trapnell
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-23 (2023)
Abstract Single-cell chromatin accessibility has emerged as a powerful means of understanding the epigenetic landscape of diverse tissues and cell types, but profiling cells from many independent specimens is challenging and costly. Here we describe
Externí odkaz:
https://doaj.org/article/11167b29a9ec4b1fa5f656373a3275ff
Autor:
Lippincott, MF, León, S, Chan, Y-M, Fergani, C, Talbi, R, Farooqi, IS, Jones, CM, Arlt, W, Stewart, SE, Cole, TR, Terasawa, E, Hall, JE, Shaw, ND, Navarro, VM, Seminara, SB
Context: Kisspeptin-Neurokinin B-Dynorphin neurons are critical regulators of the hypothalamic-pituitary-gonadal axis. Neurokinin B (NKB) and dynorphin are hypothesized to influence the frequency of gonadotropin-releasing hormone (GnRH) pulses; where
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::b09654597f734dc594b79b0cb3742252
https://eprints.whiterose.ac.uk/146589/1/jc.2019-00146.pdf
https://eprints.whiterose.ac.uk/146589/1/jc.2019-00146.pdf
Autor:
Mohammad Lotfollahi, Anna Klimovskaia Susmelj, Carlo De Donno, Leon Hetzel, Yuge Ji, Ignacio L Ibarra, Sanjay R Srivatsan, Mohsen Naghipourfar, Riza M Daza, Beth Martin, Jay Shendure, Jose L McFaline‐Figueroa, Pierre Boyeau, F Alexander Wolf, Nafissa Yakubova, Stephan Günnemann, Cole Trapnell, David Lopez‐Paz, Fabian J Theis
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 6, Pp 1-19 (2023)
Abstract Recent advances in multiplexed single‐cell transcriptomics experiments facilitate the high‐throughput study of drug and genetic perturbations. However, an exhaustive exploration of the combinatorial perturbation space is experimentally u
Externí odkaz:
https://doaj.org/article/418ea36376f0413cb228551ff196f2db
Autor:
Andrew J Aman, Lauren M Saunders, August A Carr, Sanjay Srivatasan, Colten Eberhard, Blake Carrington, Dawn Watkins-Chow, William J Pavan, Cole Trapnell, David M Parichy
Publikováno v:
eLife, Vol 12 (2023)
Pigment patterns and skin appendages are prominent features of vertebrate skin. In zebrafish, regularly patterned pigment stripes and an array of calcified scales form simultaneously in the skin during post-embryonic development. Understanding the me
Externí odkaz:
https://doaj.org/article/0404da2852a442729dc8e111e624a00c
Autor:
Cole, TR
This paper examines the role of stylized architectonic elements within civic architecture as a response to new configurations of territory and political administration. The recent regeneration of a major part of Skopje’s center, completed under the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::e63e197b85136c4bfb31786f2eaf84a8
https://hdl.handle.net/10453/122197
https://hdl.handle.net/10453/122197
Autor:
Hyeon-Jin Kim, Greg Booth, Lauren Saunders, Sanjay Srivatsan, José L. McFaline-Figueroa, Cole Trapnell
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Using spike-in controls with current single cell RNA-seq platforms remains a challenge. Here, the authors use a mixture of short, unmodified DNA oligos as a normalization standard for sci-RNAseq to improve the detection of global transcriptome change
Externí odkaz:
https://doaj.org/article/a04ceeedb7434c489f81dc97698f4e17
Autor:
Elizabeth R. Vanderwall, Kaitlyn A. Barrow, Lucille M. Rich, David F. Read, Cole Trapnell, Oghenemega Okoloko, Steven F. Ziegler, Teal S. Hallstrand, Maria P. White, Jason S. Debley
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Common alphacoronaviruses and human rhinoviruses (HRV) induce type I and III interferon (IFN) responses important to limiting viral replication in the airway epithelium. In contrast, highly pathogenic betacoronaviruses including SARS-CoV-2 m
Externí odkaz:
https://doaj.org/article/819ee770cae44309ba0d6e569bdb3358
Autor:
Brandon Hadland, Barbara Varnum-Finney, Stacey Dozono, Tessa Dignum, Cynthia Nourigat-McKay, Adam M. Heck, Takashi Ishida, Dana L. Jackson, Tomer Itkin, Jason M. Butler, Shahin Rafii, Cole Trapnell, Irwin D. Bernstein
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Here, the authors use single cell RNA-sequencing to generate an atlas of signaling interactions regulating embryonic hematopoietic stem cell (HSC) development and apply this knowledge to engineer a niche sufficient to support HSC maturation in vitro.
Externí odkaz:
https://doaj.org/article/20905f69c37543e4b5a99130d19e5860
Autor:
Tuo Shi, Marielle O Beaulieu, Lauren M Saunders, Peter Fabian, Cole Trapnell, Neil Segil, J Gage Crump, David W Raible
Publikováno v:
eLife, Vol 12 (2023)
A major cause of human deafness and vestibular dysfunction is permanent loss of the mechanosensory hair cells of the inner ear. In non-mammalian vertebrates such as zebrafish, regeneration of missing hair cells can occur throughout life. While a comp
Externí odkaz:
https://doaj.org/article/453e461ae07245579ef96440d47eaab7