Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Cole R. Michel"'
Autor:
Jamie L. Everman, Satria P. Sajuthi, Maude A. Liegeois, Nathan D. Jackson, Erik H. Collet, Michael C. Peters, Maurizio Chioccioli, Camille M. Moore, Bhavika B. Patel, Nathan Dyjack, Roger Powell, Cydney Rios, Michael T. Montgomery, Celeste Eng, Jennifer R. Elhawary, Angel C. Y. Mak, Donglei Hu, Scott Huntsman, Sandra Salazar, Luigi Feriani, Ana Fairbanks-Mahnke, Gianna L. Zinnen, Cole R. Michel, Joe Gomez, Xing Zhang, Vivian Medina, Hong Wei Chu, Pietro Cicuta, Erin D. Gordon, Pamela Zeitlin, Victor E. Ortega, Nichole Reisdorph, Eleanor M. Dunican, Monica Tang, Brett M. Elicker, Travis S. Henry, Eugene R. Bleecker, Mario Castro, Serpil C. Erzurum, Elliot Israel, Bruce D. Levy, David T. Mauger, Deborah A. Meyers, Kaharu Sumino, David S. Gierada, Annette T. Hastie, Wendy C. Moore, Loren C. Denlinger, Nizar N. Jarjour, Mark L. Schiebler, Sally E. Wenzel, Prescott G. Woodruff, Jose Rodriguez-Santana, Chad G. Pearson, Esteban G. Burchard, John V. Fahy, Max A. Seibold
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract By incompletely understood mechanisms, type 2 (T2) inflammation present in the airways of severe asthmatics drives the formation of pathologic mucus which leads to airway mucus plugging. Here we investigate the molecular role and clinical si
Externí odkaz:
https://doaj.org/article/e5fbd453726447a6a3e42371a05beeb5
Autor:
Elizabeth E. Blue, Samuel J. Huang, Alyna Khan, Katie Golden-Grant, Brenna Boyd, Elisabeth A. Rosenthal, Madelyn A. Gillentine, Leah R. Fleming, David R. Adams, Lynne Wolfe, Aimee Allworth, Michael J. Bamshad, Nikeisha J. Caruana, Sirisak Chanprasert, Jingheng Chen, Nitsuh Dargie, Daniel Doherty, Marisa W. Friederich, Fuki M. Hisama, Martha Horike-Pyne, Jessica C. Lee, Tonia E. Donovan, Daniella H. Hock, Kathleen A. Leppig, Danny E. Miller, Ghayda Mirzaa, Jane Ranchalis, Wendy H. Raskind, Cole R. Michel, Richard Reisdorph, Ulrike Schwarze, Sam Sheppeard, Samuel Strohbehn, David A. Stroud, Virginia P. Sybert, Mark H. Wener, Andrew B. Stergachis, Christina T. Lam, Gail P. Jarvik, Katrina M. Dipple, Johan L.K. Van Hove, Ian A. Glass
Publikováno v:
Rare, Vol 2, Iss , Pp 100040- (2024)
Biallelic pathogenic variants in UQCRFS1 underlie a rare form of isolated mitochondrial complex III deficiency associated with lactic acidosis and a distinctive scalp alopecia previously described in two unrelated probands. Here, we describe a partic
Externí odkaz:
https://doaj.org/article/93c294e07b004efca6d7414223356227
Autor:
Peter S. Harris, Courtney D. McGinnis, Cole R. Michel, John O. Marentette, Richard Reisdorph, James R. Roede, Kristofer S. Fritz
Publikováno v:
Redox Biology, Vol 64, Iss , Pp 102792- (2023)
In the U.S., alcohol-associated liver disease (ALD) impacts millions of people and is a major healthcare burden. While the pathology of ALD is unmistakable, the molecular mechanisms underlying ethanol hepatotoxicity are not fully understood. Hepatic
Externí odkaz:
https://doaj.org/article/450bbd80f87647e9beada0434ab3076c
Autor:
David Siegel, Peter S. Harris, Cole R. Michel, Rafael de Cabo, Kristofer S. Fritz, David Ross
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The stress induced protein NQO1 can participate in a wide range of biological pathways which are dependent upon the interaction of NQO1 with protein targets. Many of the protein-protein interactions involving NQO1 have been shown to be regulated by t
Externí odkaz:
https://doaj.org/article/df6cc9c1cdca4a708acceb091f1eea30
Autor:
Kedir N. Turi, Cole R. Michel, Jonathan Manke, Katrina A. Doenges, Nichole Reisdorph, Alison K. Bauer
Publikováno v:
Metabolites, Vol 13, Iss 3, p 406 (2023)
Allergy and asthma pathogenesis are associated with the dysregulation of metabolic pathways. To understand the effects of allergen sensitization on metabolic pathways, we conducted a multi-omics study using BALB/cJ mice sensitized to house dust mite
Externí odkaz:
https://doaj.org/article/e741711d4a764bcfab7823a1a1db9dbb
Autor:
Andrea Di Francesco, Youngshim Choi, Michel Bernier, Yingchun Zhang, Alberto Diaz-Ruiz, Miguel A. Aon, Krystle Kalafut, Margaux R. Ehrlich, Kelsey Murt, Ahmed Ali, Kevin J. Pearson, Sophie Levan, Joshua D. Preston, Alejandro Martin-Montalvo, Jennifer L. Martindale, Kotb Abdelmohsen, Cole R. Michel, Diana M. Willmes, Christine Henke, Placido Navas, Jose Manuel Villalba, David Siegel, Myriam Gorospe, Kristofer Fritz, Shyam Biswal, David Ross, Rafael de Cabo
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 6, Iss 1, Pp 1-18 (2020)
Abstract Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesi
Externí odkaz:
https://doaj.org/article/fcd69445e0874cb1841372862929c6f9
Autor:
Jennifer N. Pearson-Smith, Ruth Fulton, Christopher Q. Huynh, Anna G. Figueroa, Gia B. Huynh, Li-Ping Liang, Lindsey B. Gano, Cole R. Michel, Nichole Reisdorph, Richard Reisdorph, Kristofer S. Fritz, Eric Verdin, Manisha Patel
Publikováno v:
The Journal of Neuroscience. 43:1845-1857
Mitochondrial dysfunction is an early event in the pathogenesis of neurologic disorders and aging. Sirtuin 3 (SIRT3) regulates mitochondrial function in response to the cellular environment through the reversible deacetylation of proteins involved in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f7bfe46380102298f80c41166006ad3
https://doi.org/10.1523/jneurosci.1259-22.2023
https://doi.org/10.1523/jneurosci.1259-22.2023
Autor:
Sudipta Panja, Rooban B. Nahomi, Johanna Rankenberg, Cole R. Michel, Hanmant Gaikwad, Mi‐Hyun Nam, Ram H. Nagaraj
Publikováno v:
Aging Cell. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43a18302e7939d96fbd175c32b458fa7
https://doi.org/10.1111/acel.13797
https://doi.org/10.1111/acel.13797
Autor:
Timothy A. McKinsey, Amrut V. Ambardekar, Ying H. Lin, Hadi R. Ali, Joseph C. Cleveland, Kathleen C. Woulfe, Mark Y. Jeong, Kristofer S. Fritz, Cole R. Michel, Richard Reisdorph, Nichole Reisdorph
Publikováno v:
J Mol Cell Cardiol
Succinylation is a post-translational modification of protein lysine residues with succinyl groups derived from succinyl CoA. Succinylation is considered a significant post-translational modification with the potential to impact protein function whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8adecb78debe92ce875cb8cfc0a5d718
https://doi.org/10.1016/j.yjmcc.2019.11.159
https://doi.org/10.1016/j.yjmcc.2019.11.159
Autor:
Peter S. Harris, Cole R. Michel, Youngho Yun, Courtney D. McGinnis, Mohammed A. Assiri, Ali Reza Ahmadi, Zhaoli Sun, James R. Roede, Matthew A. Burchill, David J. Orlicky, Rebecca L. McCullough, Kristofer S. Fritz
Publikováno v:
Alcohol
Alcohol consumption remains a leading cause of liver disease worldwide, resulting in a complex array of hepatic pathologies, including steatosis, steatohepatitis, and cirrhosis. Individuals who progress to a rarer form of alcohol-associated liver dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::878abbfbf3cad980fcae14abcec55ac0
https://europepmc.org/articles/PMC8919678/
https://europepmc.org/articles/PMC8919678/
