An aromatic amino acid auxotrophic mutant of Bordetella bronchiseptica is attenuated and immunogenic in a mouse model of infection

Autor: McArthur, JD, West, NP, Cole, JN, Jungnitz, H, Guzmán, CA, Chin, J, Lehrbach, PR, Djordjevic, SP, Walker, MJ

We have constructed an aromatic amino acid auxotrophic mutant of Bordetella bronchiseptica, harbouring mutations in aroA and trpE to investigate the use of such a strain as a live-attenuated vaccine. B. bronchiseptica aroA trpE was unable to grow in

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https://hdl.handle.net/10453/8634

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Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria.

Autor: Mu A; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.; Wellcome Sanger Institute, Hinxton, UK., Klare WP; Charles Perkins Centre and School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, Australia., Baines SL; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Ignatius Pang CN; Ramaciotti Centre for Genomics, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia.; Bioinformatics Group, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia., Guérillot R; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Harbison-Price N; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia., Keller N; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia., Wilksch J; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Nhu NTK; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia., Phan MD; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia., Keller B; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia., Nijagal B; Metabolomics Australia, Bio21 Institute, The University of Melbourne, Melbourne, Australia., Tull D; Metabolomics Australia, Bio21 Institute, The University of Melbourne, Melbourne, Australia., Dayalan S; Metabolomics Australia, Bio21 Institute, The University of Melbourne, Melbourne, Australia., Chua HHC; Metabolomics Australia, Bio21 Institute, The University of Melbourne, Melbourne, Australia., Skoneczny D; Metabolomics Australia, Bio21 Institute, The University of Melbourne, Melbourne, Australia., Koval J; Ramaciotti Centre for Genomics, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia., Hachani A; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Shah AD; Monash Proteomics and Metabolomics Facility, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia., Neha N; Metabolomics Australia, Bio21 Institute, The University of Melbourne, Melbourne, Australia., Jadhav S; Metabolomics Australia, Bio21 Institute, The University of Melbourne, Melbourne, Australia., Partridge SR; Centre for Infectious Diseases and Microbiology, Westmead Hospital/ Westmead Institute, and Sydney ID, University of Sydney, Sydney, NSW, Australia., Cork AJ; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia., Peters K; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia., Bertolla O; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia., Brouwer S; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia., Hancock SJ; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia., Álvarez-Fraga L; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia., De Oliveira DMP; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia., Forde B; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia., Dale A; Charles Perkins Centre and School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, Australia., Mujchariyakul W; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Walsh CJ; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Monk I; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Fitzgerald A; Bioplatforms Australia Ltd., Sydney, NSW, Australia., Lum M; Bioplatforms Australia Ltd., Sydney, NSW, Australia., Correa-Ospina C; Ramaciotti Centre for Genomics, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia., Roy Chowdhury P; Australian Institute for Microbiology and Infection, University of Technology Sydney, Sydney, NSW, Australia., Parton RG; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.; Centre for Microscopy and Microanalysis, The University of Queensland, Brisbane, QLD, Australia., De Voss J; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia., Beckett J; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia., Monty F; Australian Genome Research Facility Ltd., Melbourne, VIC, Australia., McKinnon J; Australian Institute for Microbiology and Infection, University of Technology Sydney, Sydney, NSW, Australia., Song X; Australian Proteome Analysis Facility, Macquarie University, Sydney, Australia., Stephen JR; Australian Genome Research Facility Ltd., Melbourne, VIC, Australia., Everest M; Australian Genome Research Facility Ltd., Melbourne, VIC, Australia., Bellgard MI; Office of eResearch, Queensland University of Technology, Brisbane, QLD, Australia.; Center for Comparative Genomics, Murdoch University, Perth, WA, Australia., Tinning M; Australian Genome Research Facility Ltd., Melbourne, VIC, Australia., Leeming M; Metabolomics Australia, Bio21 Institute, The University of Melbourne, Melbourne, Australia., Hocking D; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Jebeli L; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Wang N; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Ben Zakour N; Centre for Infectious Diseases and Microbiology, Westmead Hospital/ Westmead Institute, and Sydney ID, University of Sydney, Sydney, NSW, Australia., Yasar SA; Ramaciotti Centre for Genomics, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia., Vecchiarelli S; Ramaciotti Centre for Genomics, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia., Russell T; Ramaciotti Centre for Genomics, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia., Zaw T; Australian Proteome Analysis Facility, Macquarie University, Sydney, Australia., Chen T; Department of Infectious Diseases, The Alfred Hospital and Central Clinical School, Monash University, Melbourne, VIC, Australia., Teng D; Metabolomics Australia, Bio21 Institute, The University of Melbourne, Melbourne, Australia., Kassir Z; Ramaciotti Centre for Genomics, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia., Lithgow T; Centre to Impact AMR and Infection Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Melbourne, VIC, Australia., Jenney A; Centre to Impact AMR and Infection Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Melbourne, VIC, Australia., Cole JN; Department of Pediatrics, School of Medicine, University of California at San Diego, La Jolla, CA, 92093, USA.; Skaggs School of Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA, 92093, USA., Nizet V; Department of Pediatrics, School of Medicine, University of California at San Diego, La Jolla, CA, 92093, USA.; Skaggs School of Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA, 92093, USA., Sorrell TC; Centre for Infectious Diseases and Microbiology, Westmead Hospital/ Westmead Institute, and Sydney ID, University of Sydney, Sydney, NSW, Australia., Peleg AY; Department of Infectious Diseases, The Alfred Hospital and Central Clinical School, Monash University, Melbourne, VIC, Australia.; Centre to Impact AMR and Infection Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Melbourne, VIC, Australia., Paterson DL; Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia., Beatson SA; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia., Wu J; Australian Proteome Analysis Facility, Macquarie University, Sydney, Australia., Molloy MP; Australian Proteome Analysis Facility, Macquarie University, Sydney, Australia., Syme AE; Melbourne Bioinformatics, The University of Melbourne, Melbourne, VIC, Australia., Goode RJA; Monash Proteomics and Metabolomics Facility, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia.; Commonwealth Scientific and Industrial Research Organisation, Clayton, VIC, Australia., Hunter AA; Center for Comparative Genomics, Murdoch University, Perth, WA, Australia., Bowland G; Center for Comparative Genomics, Murdoch University, Perth, WA, Australia., West NP; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia., Wilkins MR; Ramaciotti Centre for Genomics, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia., Djordjevic SP; Australian Institute for Microbiology and Infection, University of Technology Sydney, Sydney, NSW, Australia., Davies MR; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Seemann T; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Howden BP; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Pascovici D; Australian Proteome Analysis Facility, Macquarie University, Sydney, Australia., Tyagi S; Department of Infectious Diseases, The Alfred Hospital and Central Clinical School, Monash University, Melbourne, VIC, Australia., Schittenhelm RB; Monash Proteomics and Metabolomics Facility, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia., De Souza DP; Metabolomics Australia, Bio21 Institute, The University of Melbourne, Melbourne, Australia., McConville MJ; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, VIC, Australia., Iredell JR; Centre for Infectious Diseases and Microbiology, Westmead Hospital/ Westmead Institute, and Sydney ID, University of Sydney, Sydney, NSW, Australia., Cordwell SJ; Charles Perkins Centre and School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, Australia., Strugnell RA; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Stinear TP; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Schembri MA; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia., Walker MJ; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia. mark.walker@uq.edu.au.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia. mark.walker@uq.edu.au.

Publikováno v: Nature communications [Nat Commun] 2023 Mar 18; Vol. 14 (1), pp. 1530. Date of Electronic Publication: 2023 Mar 18.

Reducing the use of inhaled corticosteroids in mild-moderate COPD: an observational study in east London.

Autor: Cole JN; Centre for Primary Care and Public Health, Queen Mary University of London, London, UK. j.cole@qmul.ac.uk., Mathur RA; Centre for Primary Care and Public Health, Queen Mary University of London, London, UK., Hull SA; Centre for Primary Care and Public Health, Queen Mary University of London, London, UK.

Publikováno v: NPJ primary care respiratory medicine [NPJ Prim Care Respir Med] 2020 Jul 31; Vol. 30 (1), pp. 34. Date of Electronic Publication: 2020 Jul 31.

Group A Streptococcal M1 Protein Provides Resistance against the Antimicrobial Activity of Histones.

Autor: Döhrmann S; Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America., LaRock CN; Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America., Anderson EL; Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America., Cole JN; Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America., Ryali B; Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America., Stewart C; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America., Nonejuie P; Department of Biological Sciences, University of California San Diego, La Jolla, California, United States of America., Pogliano J; Department of Biological Sciences, University of California San Diego, La Jolla, California, United States of America., Corriden R; Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America.; Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America., Ghosh P; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America., Nizet V; Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America.; Department of Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America.; Rady Children's Hospital, San Diego, California, United States of America.

Publikováno v: Scientific reports [Sci Rep] 2017 Feb 21; Vol. 7, pp. 43039. Date of Electronic Publication: 2017 Feb 21.