Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Cole Clissold"'
Autor:
Natsuko Macabuag, William Esmieu, Perla Breccia, Rebecca Jarvis, Wesley Blackaby, Ovadia Lazari, Liudvikas Urbonas, Maria Eznarriaga, Rachel Williams, Annelieke Strijbosch, Rhea Van de Bospoort, Kim Matthews, Cole Clissold, Tammy Ladduwahetty, Huw Vater, Patrick Heaphy, Douglas G. Stafford, Hong-Jun Wang, John E. Mangette, George McAllister, Vahri Beaumont, Thomas F. Vogt, Hilary A. Wilkinson, Elizabeth M. Doherty, Celia Dominguez
Publikováno v:
Journal of medicinal chemistry. 65(18)
Huntington's disease (HD) is a lethal autosomal dominant neurodegenerative disorder resulting from a CAG repeat expansion in the huntingtin (
The development of facile, wide scope synthetic methodologies providing access to fluorinated motifs is important in medic-inal chemistry; for our purposes, we are interested in developing fluorine-tagged compounds to investigate their utility in Hun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3f0e4139d3fbdd19b314dd6d781331
https://doi.org/10.26434/chemrxiv-2022-c03kc
https://doi.org/10.26434/chemrxiv-2022-c03kc
Autor:
Sebastien Andre Campos, Sorif Uddin, Daniel Thomas, Paul Rowland, Birgit Duempelfeld, Douglas W. Thomson, Andrew Sharpe, James E. Rowedder, Kenneth David Down, Máire A. Convery, Augustin Amour, Michael Daniel Goldsmith, Grant A. McGonagle, David N. Mallett, Edith M. Hessel, Jana Krause, Kevin James Doyle, J. Nicole Hamblin, Srividya Sriskantharajah, Edward P. Cannons, Vipulkumar Kantibhai Patel, Chris D. Edwards, Cole Clissold, Nick Barton, Anderson Niall Andrew, John J. Coward
Publikováno v:
Journal of medicinal chemistry. 64(18)
Optimization of a previously reported lead series of PI3Kδ inhibitors with a novel binding mode led to the identification of a clinical candidate compound 31 (GSK251). Removal of an embedded Ames-positive heteroaromatic amine by reversing a sulfonam
Autor:
Sarah L. Martin, Dawn Yates, Grant Wishart, Ignacio Munoz-Sanjuan, Wesley Blackaby, Ovadia Lazari, Roger Cachope, Amanda Van de Poël, Leticia Toledo-Sherman, Esmieu William R K, Ivan Angulo-Herrera, Celia Dominguez, Rebecca E. Jarvis, Helen C. Cox, Amy Barnard, Graham Jones, Marcus Peacock, Sung-Wook Jang, Perla Breccia, Jennifer R. Bate, Cole Clissold, Philip Leonard, Maria Eznarriaga, Marieke Lamers, Mark Rose, George McAllister, Kim L. Matthews, Huw D. Vater
Publikováno v:
Journal of medicinal chemistry. 64(8)
Our group has recently shown that brain-penetrant ataxia telangiectasia-mutated (ATM) kinase inhibitors may have potential as novel therapeutics for the treatment of Huntington's disease (HD). However, the previously described pyranone-thioxanthenes
Autor:
Dhiren Patel, Nicola J. Costin, Cole Clissold, Martin Murray, Kevin I. Booker-Milburn, Andrew Sharpe, Richard F. Dainty, Christopher E. Anson
Publikováno v:
European Journal of Organic Chemistry. 2001:1473-1482
UV irradiation of a number of N-alkenyl-substituted maleimide derivatives leads to the formation of complex perhydroazaazulenes in excellent yields. The overall process can be considered as a formal intramolecular [5+2] cycloaddition. Substrates were
Autor:
Christopher E. Anson, Maureen J. Bibb, Kevin I. Booker-Milburn, Cole Clissold, Patrick J. Haley, David A. Hopwood, Koji Ichinose, W. Peter Revill, G. Richard Stephenson, Chandres M. Surti
Publikováno v:
Angewandte Chemie. 112:230-233
Autor:
G. Richard Stephenson, Maureen J. Bibb, Christopher E. Anson, David A. Hopwood, Kevin I. Booker-Milburn, Chandres M. Surti, Koji Ichinose, Patrick J. Haley, Cole Clissold, W. Peter Revill
Publikováno v:
Angewandte Chemie International Edition. 39:224-227
Potential "reagents" for the enantioselective reduction, and other biotransformations, of beta-keto-esters result from the genetic engineering of Streptomyces coelicolor A3(2). For example, incubation of the N-acetylcysteamine thioester 1 with the re
Autor:
Christopher E. Anson, Kevin I. Booker-Milburn, David A. Hopwood, Chandres M. Surti, W. Peter Revill, G. Richard Stephenson, Koji Ichinose, Maureen J. Bibb, Cole Clissold, Patrick J. Haley
Publikováno v:
ChemInform. 31
Autor:
Andrew Sharpe, Martin Murray, Nicola J. Costin, Cole Clissold, Kevin I. Booker-Milburn, Dhiren Patel, Christopher E. Anson, Richard F. Dainty
Publikováno v:
ChemInform. 33
UV irradiation of a number of N-alkenyl-substituted maleimide derivatives leads to the formation of complex perhydroazaazulenes in excellent yields. The overall process can be considered as a formal intramolecular [5+2] cycloaddition. Substrates were