Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Colby Zaph"'
Autor:
Harrison Sudholz, Iona S. Schuster, Momeneh Foroutan, Xavier Sng, Christopher E. Andoniou, Anh Doan, Tania Camilleri, Zihan Shen, Colby Zaph, Mariapia A. Degli-Esposti, Nicholas D. Huntington, Sebastian Scheer
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114333- (2024)
Summary: Histone methyltransferases (HMTs) are crucial in gene regulation and function, yet their role in natural killer (NK) cell biology within the tumor microenvironment (TME) remains largely unknown. We demonstrate that the HMT DOT1L limits NK ce
Externí odkaz:
https://doaj.org/article/c8754c39626e43d7815160610c1f2491
Autor:
Aidil Zaini, Thomas S. Fulford, Raelene J. Grumont, Jessica Runting, Grace Rodrigues, Judy Ng, Steve Gerondakis, Colby Zaph, Sebastian Scheer
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Group 2 innate lymphoid cells (ILC2s) are emerging as important cellular regulators of homeostatic and disease-associated immune processes. The cytokine interleukin-33 (IL-33) promotes ILC2-dependent inflammation and immunity, with IL-33 having been
Externí odkaz:
https://doaj.org/article/10e7c08fa8f74a6c88f02f11756b0ea2
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 5, p e0009340 (2021)
The current approaches to reduce the burden of chronic helminth infections in endemic areas are adequate sanitation and periodic administration of deworming drugs. Yet, resistance against some deworming drugs and reinfection can still rapidly occur e
Externí odkaz:
https://doaj.org/article/af0853be025b41d1829541c9c44a78f9
Autor:
Naveen Parmar, Kyle Burrows, Pia M Vornewald, Håvard T Lindholm, Rosalie T Zwiggelaar, Alberto Díez-Sánchez, Mara Martín-Alonso, Madeleine Fosslie, Bruce A Vallance, John Arne Dahl, Colby Zaph, Menno J Oudhoff
Publikováno v:
PLoS Pathogens, Vol 17, Iss 3, p e1009476 (2021)
Infectious and inflammatory diseases in the intestine remain a serious threat for patients world-wide. Reprogramming of the intestinal epithelium towards a protective effector state is important to manage inflammation and immunity and can be therapeu
Externí odkaz:
https://doaj.org/article/6a34613768804c59bee0718fbb1e24ef
Autor:
Sebastian Scheer, Suzanne Ackloo, Tiago S. Medina, Matthieu Schapira, Fengling Li, Jennifer A. Ward, Andrew M. Lewis, Jeffrey P. Northrop, Paul L. Richardson, H. Ümit Kaniskan, Yudao Shen, Jing Liu, David Smil, David McLeod, Carlos A. Zepeda-Velazquez, Minkui Luo, Jian Jin, Dalia Barsyte-Lovejoy, Kilian V. M. Huber, Daniel D. De Carvalho, Masoud Vedadi, Colby Zaph, Peter J. Brown, Cheryl H. Arrowsmith
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Protein methyltransferases (PMTs) are epigenetic regulatory enzymes with significant therapeutic relevance. Here the authors describe a collection of chemical inhibitors and antagonists to modulate most of the key methylation marks on histones H3 and
Externí odkaz:
https://doaj.org/article/b9017f82fb1d46769b1e67347ec72d39
Autor:
Liam Kealy, Andrea Di Pietro, Lauren Hailes, Sebastian Scheer, Lennard Dalit, Joanna R. Groom, Colby Zaph, Kim L. Good-Jacobson
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108504- (2020)
Summary: Histone modifiers are essential for the ability of immune cells to reprogram their gene expression during differentiation. The recruitment of the histone methyltransferase DOT1L (disruptor of telomeric silencing 1-like) induces oncogenic gen
Externí odkaz:
https://doaj.org/article/b1306c7f292b4b7d8367714d8c0cab9c
Autor:
Sebastian Scheer, Jessica Runting, Michael Bramhall, Brendan Russ, Aidil Zaini, Jessie Ellemor, Grace Rodrigues, Judy Ng, Colby Zaph
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108505- (2020)
Summary: CD4+ T helper (Th) cell differentiation is controlled by lineage-specific expression of transcription factors and effector proteins, as well as silencing of lineage-promiscuous genes. Lysine methyltransferases (KMTs) comprise a major class o
Externí odkaz:
https://doaj.org/article/d1b3b5c7b154446a82dffd554e7a426f
Autor:
Kyle Burrows, Frann Antignano, Alistair Chenery, Michael Bramhall, Vladimir Korinek, T Michael Underhill, Colby Zaph
Publikováno v:
PLoS Pathogens, Vol 14, Iss 2, p e1006869 (2018)
The intestinal immune system must be able to respond to a wide variety of infectious organisms while maintaining tolerance to non-pathogenic microbes and food antigens. The Vitamin A metabolite all-trans-retinoic acid (atRA) has been implicated in th
Externí odkaz:
https://doaj.org/article/5e67d551e62846a79f4df992c23c1e87
Autor:
Lucy Cooper, Lauren Hailes, Amania Sheikh, Colby Zaph, Gabrielle T Belz, Joanna R Groom, Kim L Good-Jacobson
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0208343 (2018)
Successful T-dependent humoral responses require the production of antibody-secreting plasmablasts, as well as the formation of germinal centers which eventually form high-affinity B cell memory. The ability of B cells to differentiate into germinal
Externí odkaz:
https://doaj.org/article/caac813db7934788a5c1fbfba00e8517
Autor:
Menno J Oudhoff, Frann Antignano, Alistair L Chenery, Kyle Burrows, Stephen A Redpath, Mitchell J Braam, Georgia Perona-Wright, Colby Zaph
Publikováno v:
PLoS Pathogens, Vol 12, Iss 9, p e1005876 (2016)
The intestine is a common site for a variety of pathogenic infections. Helminth infections continue to be major causes of disease worldwide, and are a significant burden on health care systems. Lysine methyltransferases are part of a family of novel
Externí odkaz:
https://doaj.org/article/e5c573989e35469eb4404c97399a442e