Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Colby R. Maldini"'
Autor:
Wilfredo F. Garcia-Beltran, Daniel T. Claiborne, Colby R. Maldini, Meredith Phelps, Vladimir Vrbanac, Marshall E. Karpel, Katharine L. Krupp, Karen A. Power, Christian L. Boutwell, Alejandro B. Balazs, Andrew M. Tager, Marcus Altfeld, Todd M. Allen
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Humanized bone marrow-liver-thymus (HuBLT) mice are a revolutionary small-animal model that has facilitated the study of human immune function and human-restricted pathogens, including human immunodeficiency virus type 1 (HIV-1). These mice recapitul
Externí odkaz:
https://doaj.org/article/e6c1b3fbd7f14cf4a30a0e8d524ed2d0
Autor:
Gloria B. Kim, Jens Fritsche, Sebastian Bunk, Andrea Mahr, Felix Unverdorben, Kevin Tosh, Hong Kong, Colby R. Maldini, Chui Lau, Sriram Srivatsa, Shuguang Jiang, Joshua Glover, Derek Dopkin, Carolyn X. Zhang, Heiko Schuster, Daniel J. Kowalewski, Valentina Goldfinger, Martina Ott, David Fuhrmann, Maike Baues, Hans Boesmueller, Christoph Schraeder, Gisela Schimmack, Colette Song, Franziska Hoffgaard, Michael Roemer, Chih-Chiang Tsou, Martin Hofmann, Thomas Treiber, Meike Hutt, Leonie Alten, Maike Jaworski, Amir Alpert, Sarah Missel, Carsten Reinhardt, Harpreet Singh, Oliver Schoor, Steffen Walter, Claudia Wagner, Dominik Maurer, Toni Weinschenk, James L. Riley
Publikováno v:
Sci Transl Med
T cell receptor (TCR)–based immunotherapy has emerged as a promising therapeutic approach for the treatment of patients with solid cancers. Identifying peptide–human leukocyte antigen (pHLA) complexes highly presented on tumors and rarely express
Autor:
Derrick L. Dopkin, Xiaochuan Shan, James L. Riley, Kevin Gayout, Joshua Glover, Rachel S. Leibman, Colby R. Maldini, Joshua P. Mills
Publikováno v:
Molecular Therapy
Mol Ther
Mol Ther
HIV infection preferentially depletes HIV-specific CD4+ T cells, thereby impairing antiviral immunity. In this study, we explored the therapeutic utility of adoptively transferred CD4+ T cells expressing an HIV-specific chimeric antigen receptor (CAR
Autor:
Alejandro B. Balazs, Marshall Karpel, Daniel T. Claiborne, Colby R. Maldini, Andrew M. Tager, Christian L. Boutwell, Katharine Krupp, Meredith Phelps, Todd M. Allen, Karen A. Power, Vladimir Vrbanac, Wilfredo F. Garcia-Beltran, Marcus Altfeld
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
Humanized bone marrow-liver-thymus (HuBLT) mice have facilitated the study of human immune function and human-restricted pathogens, including human immunodeficiency virus type 1 (HIV-1). These mice not only support robust HIV-1 infection, but also un
Publikováno v:
J Infect Dis
HIV-infected individuals successfully controlling viral replication via antiretroviral therapy often have a compromised HIV-specific T-cell immune response due to the lack of CD4 T-cell help, viral escape, T-cell exhaustion, and reduction in numbers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::554e96c038567e68f2593a16b960e1d8
https://europepmc.org/articles/PMC7883023/
https://europepmc.org/articles/PMC7883023/
Autor:
Sian Llewellyn-Lacey, Son Nguyen, Ali Naji, Takuya Sekine, Maxim Itkin, Ernesto Sparrelid, Michael R. Betts, Alberto Sada Japp, Irene Bukh Brody, Johan K. Sandberg, E. John Wherry, Samuel Darko, Sasikanth Manne, Jack P. Antel, Golnaz Vahedi, Ian Frank, Andrew D. Wells, Niklas K. Björkström, Jean Baptiste Gorin, Martin A. Ivarsson, Marcus Buggert, Colby R. Maldini, Louis J. Picker, Emma Gostick, André Perez-Potti, Leticia Kuri-Cervantes, Afam A. Okoye, David Price, Vincent H. Wu, Matthew E. Johnson, Terri M. Laufer, Daniel C. Douek, Amy Ransier, Yoav Dori, Amit Bar-Or, David H. Canaday, Laura A. Vella, Zeyu Chen, Olga Rivera-Ballesteros, Laura Hertwig
Publikováno v:
Cell
Lymphocyte migration is essential for adaptive immune surveillance. However, our current understanding of this process is rudimentary, because most human studies have been restricted to immunological analyses of blood and various tissues. To address
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85b2152bc66d92444a8f3c5a26439979
https://europepmc.org/articles/PMC9341432/
https://europepmc.org/articles/PMC9341432/
Autor:
Mark Enstrom, Katherine E. Brandenstein, Hans-Peter Kiem, Meei-Li Huang, Gavin I. Ellis, James L. Riley, Christine M. Fennessey, Blake J. Rust, Keith R. Jerome, Willimark M. Obenza, Christopher W. Peterson, Colby R. Maldini, Brandon F. Keele, Leslie S. Kean, Lucrezia Colonna, Nikhita Hegde Poole
Publikováno v:
Blood
Chimeric antigen receptor (CAR) T cells targeting CD19+ hematologic malignancies have rapidly emerged as a promising, novel therapy. In contrast, results from the few CAR T-cell studies for infectious diseases such as HIV-1 have been less convincing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98fb90641ea04beff90b90a4e0ce5dd8
https://europepmc.org/articles/PMC7544543/
https://europepmc.org/articles/PMC7544543/
Autor:
Daniel T. Claiborne, Christian L. Boutwell, Timothy Bateson, Meredith Phelps, Radiana Trifonova, James A. Hoxie, Tao Chen, Derrick L. Dopkin, Karen A. Power, Colby R. Maldini, Ken Okawa, George J. Leslie, Xiaochuan Shan, Vladimir Vrbanac, Todd M. Allen, Katharine Krupp, James L. Riley, Serah Tanno
Publikováno v:
Nat Med
An effective strategy to cure HIV will likely require a potent and sustained antiviral T cell response. Here we explored the utility of chimeric antigen receptor (CAR) T cells, expressing the CD4 ectodomain to confer specificity for the HIV envelope,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e502a9bb70766c6db89848aaf0b33a
https://europepmc.org/articles/PMC9422086/
https://europepmc.org/articles/PMC9422086/
Autor:
Christopher W. Peterson, Gavin I. Ellis, James L. Riley, A. Zhen, K. Brandenstein, Colby R. Maldini, Blake J. Rust, S. Kitchen, Hans-Peter Kiem, N. Poole
Publikováno v:
Journal of Virus Eradication, Vol 5, Iss, Pp 16-17 (2019)
Immunization of BLT Humanized Mice Redirects T Cell Responses to Gag and Reduces Acute HIV-1 Viremia
Autor:
Daniel T. Claiborne, Katharine Krupp, Todd M. Allen, Edward Seung, Elizabeth F. Mellors, Karen A. Power, Timothy Dudek, Vladimir Vrbanac, David M. Knipe, Christian L. Boutwell, Andrew M. Tager, Musie Ghebremichael, Abigail Bisesi, Colby R. Maldini
Publikováno v:
Journal of virology. 93(20)
BLT (bone marrow-liver-thymus) humanized mice, which reconstitute a functional human immune system, develop prototypic human virus-specific CD8(+) T cell responses following infection with human immunodeficiency virus type 1 (HIV-1). We explored the