Retinoic acid signaling acts as a rheostat to balance Treg function

Autor: Govindarajan Thangavelu, Gabriela Andrejeva, Sara Bolivar-Wagers, Sujeong Jin, Michael C. Zaiken, Michael Loschi, Ethan G. Aguilar, Scott N. Furlan, Chrysothemis C. Brown, Yu-Chi Lee, Cameron McDonald Hyman, Colby J. Feser, Angela Panoskaltsis-Mortari, Keli L. Hippen, Kelli P. MacDonald, William J. Murphy, Ivan Maillard, Geoffrey R. Hill, David H. Munn, Robert Zeiser, Leslie S. Kean, Jeffrey C. Rathmell, Hongbo Chi, Randolph J. Noelle, Bruce R. Blazar

Publikováno v: Cell Mol Immunol

Regulatory T cells (Tregs) promote immune homeostasis by maintaining self-tolerance and regulating inflammatory responses. Under certain inflammatory conditions, Tregs can lose their lineage stability and function. Previous studies have reported that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d110cf2e2d9fae40894c6c0e171897a6
https://doi.org/10.1038/s41423-022-00869-y

Engineering Human Cells Expressing CRISPR/Cas9-Synergistic Activation Mediators for Recombinant Protein Production

Autor: Colby J. Feser, James M. Williams, Daniel T. Lammers, Jason R. Bingham, Matthew J. Eckert, Jakub Tolar, Mark J. Osborn

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 10; Pages: 8468

Recombinant engineering for protein production commonly employs plasmid-based gene templates for introduction and expression of genes in a candidate cell system in vitro. Challenges to this approach include identifying cell types that can facilitate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdc48513a5808101f7c2a22419ebabac
https://doi.org/10.3390/ijms24108468

Disruption of HIV-1 co-receptors CCR5 and CXCR4 in primary human T cells and hematopoietic stem and progenitor cells using base editing

Autor: Alejandra Gutierrez-Guerrero, Cindy R. Eide, Jakub Tolar, David R. Liu, Kyle D. Smith, Benjamin Steinbeck, Friederike Knipping, Gregory A. Newby, Mark J. Osborn, Els Verhoeyen, Colby J. Feser, Yongxing Fang, Claudio Mussolino, Caroline Costa, Bruce R. Blazar, Anton P. McCaffrey, Keli L. Hippen, Amber N. McElroy, Samuel P. Bingea, Sarah C. Nielsen, Tatjana I. Cornu

Publikováno v: Mol Ther

Disruption of CCR5 or CXCR4, the main human immunodeficiency virus type 1 (HIV-1) co-receptors, has been shown to protect primary human CD4(+) T cells from HIV-1 infection. Base editing can install targeted point mutations in cellular genomes, and ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a295b22ca845c1df31b519cc5edeea1
https://pubmed.ncbi.nlm.nih.gov/34737067

The vimentin intermediate filament network restrains regulatory T cell suppression of graft-versus-host disease

Autor: Jonathan S. Serody, Ameeta Kelekar, Brent H. Koehn, Brian T. Fife, Laurence A. Turka, Asim Saha, Govindarajan Thangavelu, Keli L. Hippen, Sudha Kumari, Angela Panoskaltsis-Mortari, Andrew Kemal Kirchmeier, Mark J. Osborn, Cameron McDonald-Hyman, David H. Munn, Jason S. Mitchell, Guoan Zhang, Bruce R. Blazar, Colby J. Feser, Michael Loschi, Michael L. Dustin, Jiqiang Lin, James E. Muller, Thomas A. Neubert, Hongbo Chi, Michelle J. Smith, Dawn K. Reichenbach

Publikováno v: Journal of Clinical Investigation. 128:4604-4621

Regulatory T cells (Tregs) are critical for maintaining immune homeostasis. However, current Treg immunotherapies do not optimally treat inflammatory diseases in patients. Understanding the cellular processes that control Treg function may allow for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa9aa562335b3f5723f28fc2098183a
https://doi.org/10.1172/jci95713

Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease

Autor: Corey Cutler, Jerome Ritz, Arlene H. Sharpe, Katelyn Paz, David B. Miklos, William J. Murphy, Michael Zaiken, Jonathan S. Serody, Klaus Okkenhaug, David H. Munn, Leo Luznik, Colby J. Feser, John Koreth, Kelli P. A. MacDonald, Shuai Dong, Robert J. Soiffer, Bart Vanhaesebroeck, Laurence A. Turka, Anne-Katrien Stark, Stacey Tannheimer, John C. Byrd, Ryan Flynn, Ivan Maillard, Angela Panoskaltsis-Mortari, Joseph H. Antin, Geoffrey R. Hill, Jing Du, Peter T. Sage, Bruce R. Blazar, Amy J. Johnson

Publikováno v: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, vol 19, iss 6
Am J Transplant

Chronic graft-versus-host disease (cGVHD) is a leading cause of morbidity and mortality following allotransplant. Activated donor effector T cells can differentiate into pathogenic T helper (Th)-17 cells and germinal center (GC)-promoting T follicula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ec6d915ab4ed49f82137dc82ddbbb6
https://www.repository.cam.ac.uk/handle/1810/289895