Zobrazeno 1 - 10 of 213 pro vyhledávání: '"Cohick E"'
1
Akademický článek
Discovery of a novel, highly potent and orally bioavailable pyrrolidinone indole series of irreversible Myeloperoxidase (MPO) inhibitors.
Autor: Regard JB; Cardiovascular and Metabolic Diseases, Cambridge, MA, USA., Harrison TJ; Global Discovery Chemistry, Cambridge, MA, USA., Axford J; Global Discovery Chemistry, Cambridge, MA, USA., Axford L; Cardiovascular and Metabolic Diseases, Cambridge, MA, USA. Electronic address: laura.axford@novartis.com., Lee L; Cardiovascular and Metabolic Diseases, Cambridge, MA, USA., Ren X; Cardiovascular and Metabolic Diseases, Cambridge, MA, USA., Deng L; PK Sciences, Cambridge, MA, USA., Reynolds A; Technical R&D, Cambridge, MA, USA., Mao J; Global Discovery Chemistry, Cambridge, MA, USA., Liu Q; Global Discovery Chemistry, Cambridge, MA, USA., Patnaik A; Global Discovery Chemistry, Cambridge, MA, USA., Cohick E; Cardiovascular and Metabolic Diseases, Cambridge, MA, USA., Hollis-Symynkywicz M; Cardiovascular and Metabolic Diseases, Cambridge, MA, USA., Loi S; Cardiovascular and Metabolic Diseases, Cambridge, MA, USA., Riek S; Novartis Institutes for BioMedical Research, Autoimmunity, Transplantation and Inflammation, Switzlerland., McKeever U; Novartis Institutes for BioMedical Research, Autoimmunity, Transplantation and Inflammation, Switzlerland., Dunstan D; Global Discovery Chemistry, Cambridge, MA, USA., Sung M; Global Discovery Chemistry, Cambridge, MA, USA., Ware NF; Global Discovery Chemistry, Cambridge, MA, USA., Brown AP; Preclinical Safety, Novartis Institutes for BioMedical Research, Fabrikstrasse 2 Novartis Campus, Basel CH-4056, Switzerland., Hamann LG; Global Discovery Chemistry, Cambridge, MA, USA., Marcinkeviciene J; Cardiovascular and Metabolic Diseases, Cambridge, MA, USA., Patterson AW; Global Discovery Chemistry, Cambridge, MA, USA., Marro ML; Cardiovascular and Metabolic Diseases, Cambridge, MA, USA.
Publikováno v: Biochemical pharmacology [Biochem Pharmacol] 2023 Mar; Vol. 209, pp. 115418. Date of Electronic Publication: 2023 Jan 21.
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2
Akademický článek
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3
Akademický článek
Discovery and Targeting of the Signaling Controls of PNPLA3 to Effectively Reduce Transcription, Expression, and Function in Pre-Clinical NAFLD/NASH Settings.
Autor: Schwartz BE; CAMP4 Therapeutics, Cambridge, MA 02139, USA., Rajagopal V; CAMP4 Therapeutics, Cambridge, MA 02139, USA., Smith C; CAMP4 Therapeutics, Cambridge, MA 02139, USA., Cohick E; CAMP4 Therapeutics, Cambridge, MA 02139, USA., Whissell G; CAMP4 Therapeutics, Cambridge, MA 02139, USA., Gamboa M; CAMP4 Therapeutics, Cambridge, MA 02139, USA., Pai R; CAMP4 Therapeutics, Cambridge, MA 02139, USA., Sigova A; CAMP4 Therapeutics, Cambridge, MA 02139, USA., Grossman I; CAMP4 Therapeutics, Cambridge, MA 02139, USA., Bumcrot D; CAMP4 Therapeutics, Cambridge, MA 02139, USA., Sasidharan K; Department of Molecular and Clinical Medicine, University of Gothenburg, SE-413 45 Gothenburg, Sweden., Romeo S; Department of Molecular and Clinical Medicine, University of Gothenburg, SE-413 45 Gothenburg, Sweden., Sehgal A; CAMP4 Therapeutics, Cambridge, MA 02139, USA., Pingitore P; Department of Molecular and Clinical Medicine, University of Gothenburg, SE-413 45 Gothenburg, Sweden.
Publikováno v: Cells [Cells] 2020 Oct 07; Vol. 9 (10). Date of Electronic Publication: 2020 Oct 07.
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4
Akademický článek
Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO).
Autor: Patnaik A; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, United States. Electronic address: anup.patnaik@novartis.com., Axford L; Cardiovascular and Metabolic Diseases, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, United States., Deng L; PK Sciences, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, United States., Cohick E; Cardiovascular and Metabolic Diseases, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, United States., Ren X; Cardiovascular and Metabolic Diseases, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, United States., Loi S; Cardiovascular and Metabolic Diseases, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, United States., Kecman S; Cardiovascular and Metabolic Diseases, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, United States., Hollis-Symynkywicz M; Cardiovascular and Metabolic Diseases, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, United States., Harrison TJ; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, United States., Papillon JPN; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, United States., Dales N; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, United States., Hamann LG; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, United States., Lee L; Cardiovascular and Metabolic Diseases, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, United States., Regard JB; Cardiovascular and Metabolic Diseases, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, United States., Marcinkeviciene J; Cardiovascular and Metabolic Diseases, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, United States., Marro ML; Cardiovascular and Metabolic Diseases, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, United States., Patterson AW; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, United States. Electronic address: andrew.patterson@novartis.com.
Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2020 Jun 15; Vol. 28 (12), pp. 115548. Date of Electronic Publication: 2020 May 12.
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5
Akademický článek
Synergistic antitumor effect of liposomal-based formulations of olaparib and topotecan in primary epithelial ovarian cancer cells.
Autor: Romaniuk-Drapala, Aleksandra1 (AUTHOR) aromaniuk@ump.edu.pl, Skupin-Mrugalska, Paulina2 (AUTHOR), Garbuzenko, Olga3 (AUTHOR), Hatefi, Arash3,4 (AUTHOR), Minko, Tamara3,4 (AUTHOR)
Publikováno v: Cancer Cell International. 8/12/2024, Vol. 24 Issue 1, p1-14. 14p.
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6
Akademický článek
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7
Akademický článek
A Systematic Approach to Identify Candidate Transcription Factors that Control Cell Identity.
Autor: D'Alessio AC; Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA., Fan ZP; Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA; Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Wert KJ; Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA., Baranov P; Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA., Cohen MA; Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA., Saini JS; Neural Stem Cell Institute, Rensselaer, NY 12144, USA; Department of Biomedical Sciences, University at Albany, SUNY, Albany, NY 12201, USA., Cohick E; Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA., Charniga C; Neural Stem Cell Institute, Rensselaer, NY 12144, USA., Dadon D; Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Hannett NM; Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA., Young MJ; Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA., Temple S; Neural Stem Cell Institute, Rensselaer, NY 12144, USA., Jaenisch R; Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Lee TI; Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA. Electronic address: tlee@wi.mit.edu., Young RA; Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: young@wi.mit.edu.
Publikováno v: Stem cell reports [Stem Cell Reports] 2015 Nov 10; Vol. 5 (5), pp. 763-775.
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8
Akademický článek
Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours.
Autor: Ince TA; Department of Pathology, Interdisciplinary Stem Cell Institute, Braman Family Breast Cancer Institute, and Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA., Sousa AD; Department of Pathology, Interdisciplinary Stem Cell Institute, Braman Family Breast Cancer Institute, and Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA., Jones MA; Department of Pathology, Interdisciplinary Stem Cell Institute, Braman Family Breast Cancer Institute, and Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA., Harrell JC; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27514, USA., Agoston ES; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA., Krohn M; Department of Systems Biology, MD Anderson Cancer Center, Houston, Texas 77030, USA., Selfors LM; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA., Liu W; Department of Bioinformatics and Computational Biology, MD Anderson Cancer Center, Houston, Texas 77030, USA., Chen K; Department of Bioinformatics and Computational Biology, MD Anderson Cancer Center, Houston, Texas 77030, USA., Yong M; Department of Bioinformatics and Computational Biology, MD Anderson Cancer Center, Houston, Texas 77030, USA., Buchwald P; Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA., Wang B; Department of Pathology, Interdisciplinary Stem Cell Institute, Braman Family Breast Cancer Institute, and Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA., Hale KS; Department of Systems Biology, MD Anderson Cancer Center, Houston, Texas 77030, USA., Cohick E; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA., Sergent P; Vincent Center for Reproductive Biology, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA., Witt A; Department of Pathology, Interdisciplinary Stem Cell Institute, Braman Family Breast Cancer Institute, and Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA., Kozhekbaeva Z; Department of Pathology, Interdisciplinary Stem Cell Institute, Braman Family Breast Cancer Institute, and Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA., Gao S; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA., Agoston AT; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA., Merritt MA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA., Foster R; Vincent Center for Reproductive Biology, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA., Rueda BR; Vincent Center for Reproductive Biology, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA., Crum CP; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA., Brugge JS; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA., Mills GB; Department of Systems Biology, MD Anderson Cancer Center, Houston, Texas 77030, USA.
Publikováno v: Nature communications [Nat Commun] 2015 Jun 17; Vol. 6, pp. 7419. Date of Electronic Publication: 2015 Jun 17.
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9
Akademický článek
Hybridization and divergent climatic preferences drive divergence of two allopatric Gentiana species on the Qinghai–Tibet Plateau.
Autor: Fu, Peng-Cheng1 (AUTHOR), Twyford, Alex D2,3 (AUTHOR), Hao, Yu-Tong1 (AUTHOR), Zhang, Yue1 (AUTHOR), Chen, Shi-Long4 (AUTHOR), Sun, Shan-Shan1 (AUTHOR) sss823129@126.com
Publikováno v: Annals of Botany. Dec2023, Vol. 132 Issue 7, p1271-1288. 18p.
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10
Akademický článek
Genomic Analysis Reveals Candidate Genes Underlying Sex-Linked Eyelid Coloboma, Feather Color Traits, and Climatic Adaptation in Huoyan Geese.
Autor: Wen, Junhui1,2 (AUTHOR) quluj@163.com, Yu, Jincheng3 (AUTHOR) yujincheng_pi@126.com, Zhang, Li1 (AUTHOR), Li, Haiying4 (AUTHOR), Wang, Huie5,6 (AUTHOR), Gu, Hongchang1 (AUTHOR), Zhao, Xiurong2 (AUTHOR), Zhang, Xinye2 (AUTHOR), Ren, Xufang2 (AUTHOR), Wang, Gang2 (AUTHOR), Chen, Anqi2 (AUTHOR), Qu, Lujiang2 (AUTHOR) quluj@163.com
Publikováno v: Animals (2076-2615). Dec2023, Vol. 13 Issue 23, p3608. 18p.
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