The Association of Essential Metals with APOE Genotype in Alzheimer’s Disease

Autor: Patrick R. Hof, Tatjana Orct, Ena Španić, Koraljka Bačić Baronica, Spomenka Kiđemet-Piskač, Fran Borovečki, Mirjana Babić Leko, Željka Vogrinc, Vesna Lukinović Škudar, Matea Nikolac Perkovic, Goran Šimić, Nela Pivac, Ankica Sekovanić, Jasna Jurasović

Publikováno v: Journal of Alzheimer's Disease. 82:661-672

Background: The major confirmed genetic risk factor for late-onset, sporadic Alzheimer's disease (AD) is variant ɛ4 of apolipoprotein E gene (APOE). It is proposed that ApoE, a protein involved in transport of cholesterol to neurons can cause neurod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ff583c94c75bbac1f05c3503486d9c
https://doi.org/10.3233/jad-210158

Validation of microRNAs in Cerebrospinal Fluid as Biomarkers for Different Forms of Dementia in a Multicenter Study

Autor: Naomi De Roeck, Davide Chiasserini, Mareike Müller, Jill Luyckx, Jurgen A.H.R. Claassen, Hanne Struyfs, Francesca Baschieri, Marcel M. Verbeek, Lucilla Parnetti, Sebastiaan Engelborghs, Lucia Farotti, H. Bea Kuiperij, Alexandra A M Versleijen

Publikováno v: Journal of Alzheimer's disease
Journal of Alzheimer's Disease, 52, 4, pp. 1321-33
Journal of Alzheimer's Disease, 52, 1321-33

Item does not contain fulltext MicroRNAs (miRNAs) regulate translational inhibition of proteins, but are also detected in body fluids, including cerebrospinal fluid (CSF), where they may serve as disease-specific biomarkers. Previously, we showed dif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::528e08ff8c48125f90b19c8469c0ede0
https://doi.org/10.3233/jad-160038

Increased cell-free mitochondrial DNA is a marker of ongoing inflammation and better neurocognitive function in virologically suppressed HIV-infected individuals

Autor: Perez-Santiago, Josue, De Oliveira, Michelli F, Var, Susanna R, Day, Tyler RC, Woods, Steven P, Gianella, Sara, Mehta, Sanjay R

Publikováno v: Journal of neurovirology, vol 23, iss 2
Perez-Santiago, Josue; De Oliveira, Michelli F; Var, Susanna R; Day, Tyler RC; Woods, Steven P; Gianella, Sara; et al.(2017). Increased cell-free mitochondrial DNA is a marker of ongoing inflammation and better neurocognitive function in virologically suppressed HIV-infected individuals. JOURNAL OF NEUROVIROLOGY, 23(2), 283-289. doi: 10.1007/s13365-016-0497-5. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/98c6k4hz

Cell-free mitochondrial DNA (mtDNA) is a highly immunogenic molecule that is associated with several inflammatory conditions and with neurocognitive impairment during untreated HIV infection. Here, we investigate how cell-free mtDNA in cerebrospinal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::11b84aabfa343f47b0bccd3c961dd08a
https://escholarship.org/uc/item/98c6k4hz

The clinical use of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: A consensus paper from the Alzheimer's Biomarkers Standardization Initiative

Autor: Kaj Blennow, Piotr Lewczuk, Lucilla Parnetti, Bruno Dubois, José Luis Molinuevo, Charlotte E. Teunissen, Armand Perret-Liaudet, Sebastiaan Engelborghs

Publikováno v: Molinuevo, J L, Blennow, K, Dubois, B, Engelborghs, S, Lewczuk, P, Perret-Liaudet, A, Teunissen, C E & Parnetti, L 2014, ' The clinical use of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: A consensus paper from the Alzheimer's Biomarkers Standardization Initiative ', Alzheimers & Dementia, vol. 10, no. 6, pp. 808-817 . https://doi.org/10.1016/j.jalz.2014.03.003
Alzheimer's & dementia
Alzheimers & Dementia, 10(6), 808-817. Elsevier

Background Cerebrospinal fluid (CSF) biomarkers β-amyloid 1-42 (Aβ 1-42 ), also expressed as Aβ 1-42 :Aβ 1-40 ratio, T-tau, and P-tau 181P , have proven diagnostic accuracy for mild cognitive impairment and Alzheimer's disease (AD). How to use, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3682f42a7fa76d66859ea5c2d7d442e4
https://doi.org/10.1016/j.jalz.2014.03.003

A Decade of Cerebrospinal Fluid Biomarkers for Alzheimer's Disease in Belgium

Autor: Naomi De Roeck, Hanne Struyfs, Patrick Cras, Sebastiaan Engelborghs, Jill Luyckx, Jean-Jacques Martin, Ellis Niemantsverdriet, Peter Paul De Deyn, Ellen Elisa De Roeck, Maria Bjerke, Bart De Vil, Joery Goossens, Charisse Somers

Publikováno v: Journal of Alzheimer's disease

During the past ten years, over 5,000 cerebrospinal fluid (CSF) samples were analyzed at the Reference Center for Biological Markers of Dementia (BIODEM), UAntwerp, for core Alzheimer's disease (AD) CSF biomarkers: amyloid-β peptide of 42 amino acid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aba3fb2001373e40b84aa7258c00f3c
https://hdl.handle.net/20.500.14017/1fe35dec-4068-4c41-8e5e-0868e684c747