Constrained bithiazoles: Small molecule correctors of defective δf508-CFTR protein trafficking

Autor: Verkman, Alan, Coffman, KC, Nguyen, HH, Phuan, PW, Hudson, BM, Yu, GJ, Bagdasarian, AL, Montgomery, D, Lodewyk, MW, Yang, B, Yoo, CL

Publikováno v: Verkman, Alan; Coffman, KC; Nguyen, HH; Phuan, PW; Hudson, BM; Yu, GJ; et al.(2014). Constrained bithiazoles: Small molecule correctors of defective δf508-CFTR protein trafficking. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/4gh0h4d7

Conformationally constrained bithiazoles were previously found to have improved efficacy over nonconstrained bithiazoles for correction of defective cellular processing of the δF508 mutant cystic fibrosis transmembrane conductance regulator (CFTR) p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::11860a63c101eead084cab2835aeac3a
http://www.escholarship.org/uc/item/4gh0h4d7

Heterocycle-to-Heterocycle Route to Quinoline-4-amines: Reductive Heterocyclization of 3-(2-Nitrophenyl)isoxazoles.

Autor: Coffman KC; Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, http://chemistry.ucdavis.edu/faculty/department_faculty/mark_kurth.html., Duong V; Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, http://chemistry.ucdavis.edu/faculty/department_faculty/mark_kurth.html., Bagdasarian AL; Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, http://chemistry.ucdavis.edu/faculty/department_faculty/mark_kurth.html., Fettinger JC; Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, http://chemistry.ucdavis.edu/faculty/department_faculty/mark_kurth.html., Haddadin MJ; Department of Chemistry, Department American University of Beirut, Institution, Beirut, Lebanon., Kurth MJ; Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, http://chemistry.ucdavis.edu/faculty/department_faculty/mark_kurth.html.

Publikováno v: European journal of organic chemistry [European J Org Chem] 2014 Dec; Vol. 2014 (34), pp. 7651-7657.

Heterocycle-heterocycle strategies: (2-nitrophenyl)isoxazole precursors to 4-aminoquinolines, 1H-indoles, and quinolin-4(1H)-ones.

Autor: Coffman KC; Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, United States., Palazzo TA, Hartley TP, Fettinger JC, Tantillo DJ, Kurth MJ

Publikováno v: Organic letters [Org Lett] 2013 Apr 19; Vol. 15 (8), pp. 2062-5. Date of Electronic Publication: 2013 Apr 04.

Orthogonally protected thiazole and isoxazole diamino acids: an efficient synthetic route.

Autor: Butler JD; Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA., Coffman KC, Ziebart KT, Toney MD, Kurth MJ

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2010 Aug 09; Vol. 16 (30), pp. 9002-5.