Functional evidence that S-nitroso-L-cysteine may be a candidate carotid body neurotransmitter.

Autor: Getsy PM; Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA. Electronic address: pxg55@case.edu., Coffee GA; Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA., Bates JN; Department of Anesthesiology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA., Baby SM; Section of Biology, Galleon Pharmaceuticals, Inc, Horsham, PA, USA., Seckler JM; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA., Palmer LA; Department of Pediatrics, University of Virginia, Charlottesville, VA, USA., Lewis SJ; Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA; Department of Pharmacology, Case Western Reserve University, Cleveland, OH, USA; Functional Electrical Stimulation Center, Case Western Reserve University, Cleveland, OH, USA.

Publikováno v: Neuropharmacology [Neuropharmacology] 2024 Nov 20; Vol. 265, pp. 110229. Date of Electronic Publication: 2024 Nov 20.

Tropine exacerbates the ventilatory depressant actions of fentanyl in freely-moving rats.

Autor: Getsy PM; Department of Pediatrics, Case Western Reserve University, Cleveland, OH, United States., May WJ; Department of Pediatrics, University of Virginia, Charlottesville, VA, United States., Young AP; Department of Pediatrics, University of Virginia, Charlottesville, VA, United States., Baby SM; Galleon Pharmaceuticals, Inc., Horsham, PA, United States., Coffee GA; Department of Pediatrics, Case Western Reserve University, Cleveland, OH, United States., Bates JN; Department of Anesthesiology, University of Iowa Hospitals and Clinics Iowa, Iowa City, IA, United States., Hsieh YH; Division of Pulmonary, Critical Care and Sleep Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, United States., Lewis SJ; Department of Pediatrics, Case Western Reserve University, Cleveland, OH, United States.; Department of Pharmacology, Case Western Reserve University, Cleveland, OH, United States.; Functional Electrical Stimulation Center, Case Western Reserve University, Cleveland, OH, United States.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2024 Jun 24; Vol. 15, pp. 1405461. Date of Electronic Publication: 2024 Jun 24 (Print Publication: 2024).

L-NAC and L-NAC methyl ester prevent and overcome physical dependence to fentanyl in male rats.

Autor: Bates JN; Department of Anesthesiology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.; Atelerix Life Sciences Inc., 300 East Main Street, Suite 202, Charlottesville, VA, USA., Baby SM; Section of Biology, Galleon Pharmaceuticals, Inc, Horsham, PA, USA.; Translational Sciences Treatment Discovery, Galvani Bioelectronics, Inc, 1250 S Collegeville Rd, Collegeville, PA, USA., Getsy PM; Department of Pediatrics, Division of Pulmonology, Allergy, and Immunology, Case Western Reserve University, Cleveland, OH, USA., Coffee GA; Department of Pediatrics, Division of Pulmonology, Allergy, and Immunology, Case Western Reserve University, Cleveland, OH, USA., Hsieh YH; Division of Pulmonary, Critical Care and Sleep Medicine, Case Western Reserve University, Cleveland, OH, USA., Knauss ZT; Department of Biological Sciences, Kent State University, Kent, OH, USA., Dahan A; Department of Anesthesiology, Leiden University Medical Center, Leiden, Netherlands., Bubier JA; Jackson Laboratories, Bar Harbor, ME, USA., MacFarlane PM; Department of Pediatrics, Division of Pulmonology, Allergy, and Immunology, Case Western Reserve University, Cleveland, OH, USA., Mueller D; Department of Biological Sciences, Kent State University, Kent, OH, USA., Lewis SJ; Department of Pediatrics, Division of Pulmonology, Allergy, and Immunology, Case Western Reserve University, Cleveland, OH, USA. sjl78@case.edu.; Department of Pharmacology, Case Western Reserve University, Cleveland, OH, USA. sjl78@case.edu.; Functional Electrical Stimulation Center, Case Western Reserve University, Cleveland, OH, USA. sjl78@case.edu.; Department of Pediatrics, Division of Pulmonology, Allergy and Immunology, School of Medicine,, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, USA. sjl78@case.edu.

Publikováno v: Scientific reports [Sci Rep] 2024 Apr 20; Vol. 14 (1), pp. 9091. Date of Electronic Publication: 2024 Apr 20.

Lipophilic analogues of D-cysteine prevent and reverse physical dependence to fentanyl in male rats.

Autor: Bates JN; Department of Anesthesiology, University of Iowa Hospitals and Clinics, Iowa City, IA, United States., Getsy PM; Department of Pediatrics, Case Western Reserve University, Cleveland, OH, United States., Coffee GA; Department of Pediatrics, Case Western Reserve University, Cleveland, OH, United States., Baby SM; Section of Biology, Galleon Pharmaceuticals, Inc., Horsham, PA, United States., MacFarlane PM; Department of Pediatrics, Case Western Reserve University, Cleveland, OH, United States., Hsieh YH; Division of Pulmonary, Critical Care and Sleep Medicine, Case Western Reserve University, Cleveland, OH, United States., Knauss ZT; Department of Biological Sciences, Kent State University, Kent, OH, United States., Bubier JA; The Jackson Laboratory, Bar Harbor, ME, United States., Mueller D; Department of Biological Sciences, Kent State University, Kent, OH, United States., Lewis SJ; Department of Pediatrics, Case Western Reserve University, Cleveland, OH, United States.; Department of Pharmacology, Case Western Reserve University, Cleveland, OH, United States.; Functional Electrical Stimulation Center, Case Western Reserve University, Cleveland, OH, United States.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2024 Apr 05; Vol. 14, pp. 1336440. Date of Electronic Publication: 2024 Apr 05 (Print Publication: 2023).

L-cysteine ethylester reverses the adverse effects of morphine on breathing and arterial blood-gas chemistry while minimally affecting antinociception in unanesthetized rats.

Autor: Baby SM; Department of Drug Discovery, Galleon Pharmaceuticals, Inc., Horsham, PA, USA., May WJ; Pediatric Respiratory Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA., Young AP; Pediatric Respiratory Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA., Wilson CG; Basic Sciences, Division of Physiology, School of Medicine, Loma Linda University, USA., Getsy PM; Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA., Coffee GA; Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA., Lewis THJ; Lerner Institute, Cleveland Clinic, Cleveland, OH, USA., Hsieh YH; Division of Pulmonary, Critical Care and Sleep Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA., Bates JN; Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, IA, USA., Lewis SJ; Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA; Department of Pharmacology, Case Western Reserve University, Cleveland, OH, USA. Electronic address: sjl78@case.edu.

Publikováno v: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Feb; Vol. 171, pp. 116081. Date of Electronic Publication: 2024 Jan 13.