Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Coert Margadant"'
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102473- (2023)
Summary: Integrin-dependent cell-extracellular matrix adhesion is essential for wound healing, embryonic development, immunity, and tissue organization. Here, we present a protocol for the imaging and quantitative analysis of integrin-dependent cell-
Externí odkaz:
https://doaj.org/article/7b1d709546c84eb8bff5cfd145aa22ff
Autor:
Marije Kat, Ellie Karampini, Arie J. Hoogendijk, Petra E. Bürgisser, Aat A. Mulder, Floris P.J. van Alphen, Jenny Olins, Dirk Geerts, Maartje van den Biggelaar, Coert Margadant, Jan Voorberg, Ruben Bierings
Publikováno v:
Haematologica, Vol 107, Iss 8 (2022)
Von Willebrand factor (VWF) is a multimeric hemostatic protein primarily synthesized in endothelial cells. VWF is stored in endothelial storage organelles, the Weibel-Palade bodies (WPB), whose biogenesis strongly depends on VWF anterograde trafficki
Externí odkaz:
https://doaj.org/article/3f3b76fdbfd641bd82110fcb6a81d836
Autor:
Lanette Kempers, Ivo van der Bijl, Anne-Marieke D. van Stalborch, Bas Ponsioen, Coert Margadant
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100690- (2021)
Summary: We describe an optimized, cost-effective, reproducible, and robust protocol to study sprouting angiogenesis in glass-bottom 96-well plates by confocal microscopy, ideal for screening of drug or shRNA libraries. Effective and stable knockdown
Externí odkaz:
https://doaj.org/article/56ea7521564549ae946a0a00a55e8343
Autor:
Maaike Schillemans, Marije Kat, Jurjen Westeneng, Anastasia Gangaev, Menno Hofman, Benjamin Nota, Floris P. J. van Alphen, Martin de Boer, Maartje van den Biggelaar, Coert Margadant, Jan Voorberg, Ruben Bierings
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 3, Iss 4, Pp 718-732 (2019)
Abstract Background Synthesis of the hemostatic protein von Willebrand factor (VWF) drives formation of endothelial storage organelles called Weibel‐Palade bodies (WPBs). In the absence of VWF, angiogenic and inflammatory mediators that are costore
Externí odkaz:
https://doaj.org/article/f5bad20c9eee478db4af6502d1df88c3
Autor:
Tom A.P. Driedonks, Sanne Mol, Sanne de Bruin, Anna-Linda Peters, Xiaogang Zhang, Marthe F.S. Lindenbergh, Boukje M. Beuger, Anne-Marieke D. van Stalborch, Thom Spaan, Esther C. de Jong, Erhard van der Vries, Coert Margadant, Robin van Bruggen, Alexander P.J. Vlaar, Tom Groot Kormelink, Esther N.M. Nolte-‘T Hoen
Publikováno v:
Journal of Extracellular Vesicles, Vol 9, Iss 1 (2020)
Major efforts are made to characterize the presence of microRNA (miRNA) and messenger RNA in blood plasma to discover novel disease-associated biomarkers. MiRNAs in plasma are associated to several types of macromolecular structures, including extrac
Externí odkaz:
https://doaj.org/article/e9ad872f86504c0690a08ad24582c908
Autor:
Caspar T. H. Jonker, Romain Galmes, Tineke Veenendaal, Corlinda ten Brink, Reini E. N. van der Welle, Nalan Liv, Johan de Rooij, Andrew A. Peden, Peter van der Sluijs, Coert Margadant, Judith Klumperman
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/99c88c2061e746ffab9ef57578589c44
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65341 (2013)
Loss-of-function mutations in the gene encoding the integrin co-activator kindlin-1 cause Kindler syndrome. We report a novel kindlin-1-deficient keratinocyte cell line derived from a Kindler syndrome patient. Despite the expression of kindlin-2, the
Externí odkaz:
https://doaj.org/article/aa8465d1c16c40229262f64f621f972c
Publikováno v:
FEBS journal, 289(22), 6863-6870. Wiley-Blackwell
FEBS Journal, 289(22), 6863-6870. Wiley-Blackwell Publishing Ltd
Kat, M, Margadant, C, Voorberg, J & Bierings, R 2022, ' Dispatch and delivery at the ER–Golgi interface : how endothelial cells tune their hemostatic response ', FEBS Journal, vol. 289, no. 22, pp. 6863-6870 . https://doi.org/10.1111/febs.16421
FEBS Journal, 289(22), 6863-6870. Wiley-Blackwell Publishing Ltd
Kat, M, Margadant, C, Voorberg, J & Bierings, R 2022, ' Dispatch and delivery at the ER–Golgi interface : how endothelial cells tune their hemostatic response ', FEBS Journal, vol. 289, no. 22, pp. 6863-6870 . https://doi.org/10.1111/febs.16421
Von Willebrand factor (VWF) is a glycoprotein that is secreted into the circulation and controls bleeding by promoting adhesion and aggregation of blood platelets at sites of vascular injury. Substantial inter-individual variation in VWF plasma level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1438de33d9346dbf05d5069cd58dd164
https://doi.org/10.1111/febs.16421
https://doi.org/10.1111/febs.16421
Autor:
Jurjan Aman, Coert Margadant
Publikováno v:
Aman, J & Margadant, C 2023, ' Integrin-Dependent Cell-Matrix Adhesion in Endothelial Health and Disease ', Circulation Research, vol. 132, no. 3, pp. 355-378 . https://doi.org/10.1161/CIRCRESAHA.122.322332
The endothelium is a dynamic, semipermeable layer lining all blood vessels, regulating blood vessel formation and barrier function. Proper composition and function of the endothelial barrier are required for fluid homeostasis, and clinical conditions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953e6c9c45a977cc41c244526730f344
https://research.vumc.nl/en/publications/56b4a02c-132e-4783-8505-3c3602260f63
https://research.vumc.nl/en/publications/56b4a02c-132e-4783-8505-3c3602260f63
Autor:
Marije Kat, Iris van Moort, Petra E. Bürgisser, Taco W. Kuijpers, Menno Hofman, Marie Favier, Rémi Favier, Coert Margadant, Jan Voorberg, Ruben Bierings
Publikováno v:
Research and practice in thrombosis and haemostasis, 7(2):100086. Wiley-Blackwell Publishing Ltd
Research and Practice in Thrombosis and Haemostasis, 7(2):100086. Wiley-Blackwell Publishing Ltd
Kat, M, van Moort, I, Bürgisser, P E, Kuijpers, T W, Hofman, M, Favier, M, Favier, R M, Margadant, C, Voorberg, J & Bierings, R 2023, ' Mutations in Neurobeachin-like 2 do not impact Weibel-Palade body biogenesis and von Willebrand factor secretion in gray platelet syndrome Endothelial Colony Forming Cells ', Research and practice in thrombosis and haemostasis, vol. 7, no. 2, 100086 . https://doi.org/10.1016/j.rpth.2023.100086
Research and Practice in Thrombosis and Haemostasis, 7(2):100086. Wiley-Blackwell Publishing Ltd
Kat, M, van Moort, I, Bürgisser, P E, Kuijpers, T W, Hofman, M, Favier, M, Favier, R M, Margadant, C, Voorberg, J & Bierings, R 2023, ' Mutations in Neurobeachin-like 2 do not impact Weibel-Palade body biogenesis and von Willebrand factor secretion in gray platelet syndrome Endothelial Colony Forming Cells ', Research and practice in thrombosis and haemostasis, vol. 7, no. 2, 100086 . https://doi.org/10.1016/j.rpth.2023.100086
Background: Patients with gray platelet syndrome (GPS) and Neurobeachin-like 2 (NBEAL2) deficiency produce platelets lacking alpha-granules (AGs) and present with lifelong bleeding symptoms. AGs are lysosome-related organelles and store the hemostati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::664091d35cf28063796c19ea5cd5628d
https://pure.amc.nl/en/publications/mutations-in-neurobeachinlike-2-do-not-impact-weibelpalade-body-biogenesis-and-von-willebrand-factor-secretion-in-gray-platelet-syndrome-endothelial-colony-forming-cells(6c9f3553-7728-49d7-b147-ceaa2773a5d6).html
https://pure.amc.nl/en/publications/mutations-in-neurobeachinlike-2-do-not-impact-weibelpalade-body-biogenesis-and-von-willebrand-factor-secretion-in-gray-platelet-syndrome-endothelial-colony-forming-cells(6c9f3553-7728-49d7-b147-ceaa2773a5d6).html