Data from An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody–Drug Conjugate for the Treatment of Hormone Receptor–Positive Breast Cancer

Autor: Jagath R. Junutula, Paul Polakis, Richard H. Scheller, Mark S. Dennis, Deepak Sampath, Jo-Anne Hongo, Helga Raab, Katherine R. Kozak, Aimee Fourie-O'Donohue, Ron Firestein, Robert Piskol, Eric Cheng, Mary Ann T. Go, Kirsten A. Poon, Fiona Zhong, Rachana Ohri, Coenraad Kuijl, Dongwei Li, Melissa M. Schutten, Meredith Hazen, Yvonne Chen, Lisa M. Crocker, Sunil Bhakta

Luminal A (hormone receptor-positive) breast cancer constitutes 70% of total breast cancer patients. In an attempt to develop a targeted therapeutic for this cancer indication, we have identified and characterized Glial cell line–Derived Neurotroph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6ebbf88322d045b6d0c4b08c2c22021d
https://doi.org/10.1158/1535-7163.c.6537960.v1

Mycobacterium tuberculosis Toxin CpnT Is an ESX-5 Substrate and Requires Three Type VII Secretion Systems for Intracellular Secretion

Autor: B. Izquierdo Lafuente, Alexander Speer, Roy Ummels, Wilbert Bitter, Coenraad Kuijl

Publikováno v: Izquierdo Lafuente, B, Ummels, R, Kuijl, C, Bitter, W & Speer, A 2021, ' Mycobacterium tuberculosis toxin cpnt is an esx-5 substrate and requires three type vii secretion systems for intracellular secretion ', mBio, vol. 12, no. 2, e02983-20, pp. 1-16 . https://doi.org/10.1128/mBio.02983-20
mBio
mBio, 12(2):e02983-20, 1-16. American Society for Microbiology
mBio, Vol 12, Iss 2 (2021)

CpnT, a NAD+ glycohydrolase, is the only known toxin that is secreted by Mycobacterium tuberculosis. CpnT is composed of two domains; the C-terminal domain is the toxin, whereas the N-terminal domain is required for secretion.
CpnT, a NAD+ glyco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f97c2e9f345cfdb90b8d18db4dfd1569
https://doi.org/10.1128/mbio.02983-20

Efficient genome editing in pathogenic mycobacteria using Streptococcus thermophilus CRISPR1-Cas9

Autor: Sergey Nejentsev, Aniek S. Meijers, Wilbert Bitter, J.J. Maaskant, Ran Troost, Coenraad Kuijl, Roy Ummels, Alexander Speer

Publikováno v: Tuberculosis, 124:101983. Churchill Livingstone
Meijers, A S, Troost, R, Ummels, R, Maaskant, J, Speer, A, Nejentsev, S, Bitter, W & Kuijl, C P 2020, ' Efficient genome editing in pathogenic mycobacteria using Streptococcus thermophilus CRISPR1-Cas9 ', Tuberculosis, vol. 124, 101983 . https://doi.org/10.1016/j.tube.2020.101983
Tuberculosis (Edinb)
Tuberculosis

The ability to genetically engineer pathogenic mycobacteria has increased significantly over the last decades due to the generation of new molecular tools. Recently, the application of the Streptococcus pyogenes and the Streptococcus thermophilus CRI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674197def8b545024fb44356a834dde0
https://hdl.handle.net/1871.1/9838c9f5-a93a-4847-9414-ecb41492eed6

An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer

Autor: Ron Firestein, Yvonne Chen, Rachana Ohri, Richard H. Scheller, Helga Raab, Katherine R. Kozak, Paul Polakis, Coenraad Kuijl, Dongwei Li, Meredith Hazen, Lisa Crocker, Robert Piskol, Mark S. Dennis, Jagath Reddy Junutula, Eric Cheng, Deepak Sampath, Kirsten Achilles Poon, Aimee Fourie-O'Donohue, Sunil Bhakta, Fiona Zhong, Melissa Schutten, Mary Ann T. Go, Jo-Anne Hongo

Publikováno v: Bhakta, S, Crocker, L M, Chen, Y, Hazen, M, Schutten, M M, Li, D, Kuijl, C, Ohri, R, Zhong, F, Poon, K A, Go, M A T, Cheng, E, Piskol, R, Firestein, R, Fourie-O'Donohue, A, Kozak, K R, Raab, H, Hongo, J-A, Sampath, D, Dennis, M S, Scheller, R H, Polakis, P & Junutula, J R 2018, ' An anti-gdnf family receptor alpha 1 (gfra1 antibody–drug conjugate for the treatment of hormone receptor–positive breast cancer ', Molecular Cancer Therapeutics, vol. 17, no. 3, pp. 638-649 . https://doi.org/10.1158/1535-7163.MCT-17-0813
Molecular Cancer Therapeutics, 17(3), 638-649. American Association for Cancer Research Inc.

Luminal A (hormone receptor-positive) breast cancer constitutes 70% of total breast cancer patients. In an attempt to develop a targeted therapeutic for this cancer indication, we have identified and characterized Glial cell line–Derived Neurotroph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d4699f5d64f071d6e57818b2f7ff5b
https://pubmed.ncbi.nlm.nih.gov/31676543

Rac and Rab GTPases dual effector Nischarin regulates vesicle maturation to facilitate survival of intracellular bacteria

Autor: Jacques Neefjes, Hans Janssen, Monica Calero, Karen E. Ervin, Jagath Reddy Junutula, Sobhanaditya Jonnalagadda, Richard H. Scheller, Coenraad Kuijl, Manohar Pilli, Suresh K. Alahari, Poh-Sim Khoo

Publikováno v: The EMBO Journal. 32:713-727

The intracellular pathogenic bacterium Salmonella enterica serovar typhimurium (Salmonella) relies on acidification of the Salmonella-containing vacuole (SCV) for survival inside host cells. The transport and fusion of membrane-bound compartments in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::031824c2b9cebcd6635b5258133c373a
https://doi.org/10.1038/emboj.2013.10