Zobrazeno 1 - 10
of 302
pro vyhledávání: '"Coenraad Hemker"'
Autor:
Romy M.W. Kremers, Stéphane Zuily, Hilde Kelchtermans, Tessa C. Peters, Saartje Bloemen, Véronique Regnault, H. Coenraad Hemker, Philip G. de Groot, Denis Wahl, Bas de Laat
Publikováno v:
Blood Advances, Vol 2, Iss 11, Pp 1315-1324 (2018)
Abstract: Antiphospholipid syndrome (APS) is a condition in which the presence of antibodies against phospholipid-binding proteins is associated with thrombophilia and/or pregnancy morbidity. Although antiphospholipid antibodies have anticoagulant ch
Externí odkaz:
https://doaj.org/article/7767c9c787474847b0d80b489c894b54
Publikováno v:
Thrombosis Journal, Vol 16, Iss 1, Pp 1-4 (2018)
Abstract Accurate thrombin generation determination by calibrated automated thrombinography can be sustained when reducing the plasma and reagent volumes up to half, but not for higher reductions or plasma dilutions.
Externí odkaz:
https://doaj.org/article/037f683c0f674e7ba0eab3bfaf8e3d11
Publikováno v:
Frontiers in Medicine, Vol 6 (2019)
Heparins inhibit the thrombin forming capacity of plasma, i. e., the endogenous thrombin potential (ETP), by their anti-thrombin (aIIa) activity, the anti-factor Xa (aXa) activity is of minimal importance. This holds for both unfractionated heparin (
Externí odkaz:
https://doaj.org/article/5790160a584149a9b945ee95128a3e6f
Autor:
Romy M W Kremers, Marie-Claire Kleinegris, Marisa Ninivaggi, Bas de Laat, Hugo Ten Cate, Ger H Koek, Rob J Wagenvoord, H Coenraad Hemker
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177020 (2017)
Impaired coagulation factor synthesis in cirrhosis causes a reduction of most pro- and anticoagulant factors. Cirrhosis patients show no clear bleeding or thrombotic phenotype, although they are at risk for both types of hemostatic event. Thrombin ge
Externí odkaz:
https://doaj.org/article/1074baf786d4412cbed9327212ed6273
Autor:
Hugo ten Cate, H. Coenraad Hemker
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 8 (2016)
Externí odkaz:
https://doaj.org/article/f83440b293374683bd8bcf34372d7e66
Autor:
Evelien Schurgers, Martijn Moorlag, Coenraad Hemker, Theo Lindhout, Hilde Kelchtermans, Bas de Laat
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149135 (2016)
To better understand hypercoagulability as an underlying cause for thrombosis, the leading cause of death in the Western world, new assays to study ex vivo coagulation are essential. The zebrafish is generally accepted as a good model for human hemos
Externí odkaz:
https://doaj.org/article/e088a42a6cee4c41b6746053631bef05
Autor:
H. Coenraad Hemker, Roy Schrijver, Chris P. M. Reutelingsperger, Danielle M. H. Beurskens, Joram Huckriede, Gerry A. F. Nicolaes
Publikováno v:
Thrombosis and Haemostasis. 120:1371-1383
Heparins represent one of the most frequently used pharmacotherapeutics. Discovered around 1926, routine clinical anticoagulant use of heparin was initiated only after the publication of several seminal papers in the early 1970s by the group of Kakka
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b26df757fbd1bb6c4551e6d439e730b9
https://doi.org/10.1055/s-0040-1715460
https://doi.org/10.1055/s-0040-1715460
Autor:
Romy M W Kremers, Abdulrahman B O Mohamed, Leonie Pelkmans, Salwa Hindawi, H Coenraad Hemker, H Bas de Laat, Dana Huskens, Raed Al Dieri
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141491 (2015)
Individuals with blood group O have a higher bleeding risk than non-O blood groups. This could be explained by the lower levels of FVIII and von Willebrand Factor (VWF) levels in O individuals. We investigated the relationship between blood groups, t
Externí odkaz:
https://doaj.org/article/cf843ff520904d30bc8fdaf0bf7c446f
Autor:
Panteleev, Mikhail A.1,2,3 mapanteleev@yandex.ru, Coenraad Hemker, Hendrik4 hc.hemker@thrombin.com
Publikováno v:
Thrombosis Journal. 2015, Vol. 13 Issue 1, p1-8. 8p.
Autor:
H. Coenraad Hemker, Henri M. H. Spronk, Hugo ten Cate, Yvonne M. C. Henskens, Anne Marije Hulshof
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 2590, p 2590 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 2590, p 2590 (2021)
Fibrinogen is a well-known risk factor for arterial and venous thrombosis. Its function is not restricted to clot formation, however, as it partakes in a complex interplay between thrombin, soluble plasma fibrinogen, and deposited fibrin matrices. Fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c8f84f3c8bd414b1a6abd7b1a87f2c
https://pubmed.ncbi.nlm.nih.gov/33806700
https://pubmed.ncbi.nlm.nih.gov/33806700