A novel Fc-engineered cathepsin D-targeting antibody enhances ADCC, triggers tumor-infiltrating NK cell recruitment, and improves treatment with paclitaxel and enzalutamide in triple-negative breast cancer.

Autor: Desroys du Roure P; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France., Lajoie L; Université de Tours - INRAE, UMR1282, Infectiologie et Santé Publique (ISP), équipe BioMédicaments Anti-Parasitaires (BioMAP), Tours, France., Mallavialle A; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France., Alcaraz LB; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France., Mansouri H; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France.; RHEM, IRCM, Montpellier, France., Fenou L; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France., Garambois V; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France., Rubio L; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France., David T; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France., Coenon L; IRMB, University of Montpellier, INSERM, CNRS, CHU Montpellier, Montpellier, France., Boissière-Michot F; Translational Research Unit, ICM, Montpellier, France., Chateau MC; Translational Research Unit, ICM, Montpellier, France., Ngo G; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France., Jarlier M; Biometry Department, ICM, Montpellier, France., Villalba M; IRMB, University of Montpellier, INSERM, CNRS, CHU Montpellier, Montpellier, France.; Institut du Cancer Avignon-Provence Sainte Catherine, Avignon, France., Martineau P; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France., Laurent-Matha V; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France., Roger P; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France.; Department of Pathology, CHU Nîmes, Nimes, France., Guiu S; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France.; Department of Medical Oncology, ICM, Montpellier, France., Chardès T; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France.; CNRS, Centre national de la recherche Scientifique, Paris, F-75016, France., Gros L; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France.; CNRS, Centre national de la recherche Scientifique, Paris, F-75016, France., Liaudet-Coopman E; IRCM, INSERM U1194, University of Montpellier, ICM, Montpellier, France emmanuelle.liaudet-coopman@inserm.fr.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2024 Jan 30; Vol. 12 (1). Date of Electronic Publication: 2024 Jan 30.

g-NK cells from umbilical cord blood are phenotypically and functionally different than g-NK cells from peripheral blood.

Autor: Gao F; Department of Pathology, School of Basic Medicine, Central South University, Changsha, China.; IRMB, INSERM, CHRU de Montpellier, University Montpellier, Montpellier, France., Mora MC; IRMB, INSERM, CHRU de Montpellier, University Montpellier, Montpellier, France., Constantinides M; IRMB, INSERM, CHRU de Montpellier, University Montpellier, Montpellier, France., Coenon L; IRMB, INSERM, CHRU de Montpellier, University Montpellier, Montpellier, France., Multrier C; IRMB, INSERM, CHRU de Montpellier, University Montpellier, Montpellier, France., Vaillant L; IRMB, INSERM, CHRU de Montpellier, University Montpellier, Montpellier, France., Zhang T; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Villalba M; IRMB, INSERM, CHRU de Montpellier, University Montpellier, Montpellier, France.; Institut du Cancer Avignon-Provence Sainte Catherine, Avignon, France.; IRMB, INSERM, CHRU de Montpellier, CNRS, Univ Montpellier, Montpellier, France.

Publikováno v: Oncoimmunology [Oncoimmunology] 2023 Nov 22; Vol. 12 (1), pp. 2283353. Date of Electronic Publication: 2023 Nov 22 (Print Publication: 2023).

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Metformin sensitizes leukemic cells to cytotoxic lymphocytes by increasing expression of intercellular adhesion molecule-1 (ICAM-1).

Autor: Allende-Vega N; IRMB, Univ Montpellier, INSERM, Montpellier, France., Marco Brualla J; Apoptosis, Immunity and Cancer Group, Department of Biochemistry and Molecular and Cell Biology, Faculty of Sciences, University of Zaragoza and Aragón Health Research Institute (IIS Aragón), Campus San Francisco Sq., 50009, Zaragoza, Spain., Falvo P; Laboratory of Hematology-Oncology, European Institute of Oncology IRCCS, Milan, Italy., Alexia C; IRMB, Univ Montpellier, INSERM, Montpellier, France., Constantinides M; IRMB, Univ Montpellier, INSERM, Montpellier, France., Fayd'herbe de Maudave A; IRMB, Univ Montpellier, INSERM, Montpellier, France., Coenon L; IRMB, Univ Montpellier, INSERM, Montpellier, France., Gitenay D; IRMB, Univ Montpellier, INSERM, Montpellier, France., Mitola G; Laboratory of Hematology-Oncology, European Institute of Oncology IRCCS, Milan, Italy., Massa P; Laboratory of Hematology-Oncology, European Institute of Oncology IRCCS, Milan, Italy., Orecchioni S; Laboratory of Hematology-Oncology, European Institute of Oncology IRCCS, Milan, Italy., Bertolini F; Laboratory of Hematology-Oncology, European Institute of Oncology IRCCS, Milan, Italy., Marzo I; Apoptosis, Immunity and Cancer Group, Department of Biochemistry and Molecular and Cell Biology, Faculty of Sciences, University of Zaragoza and Aragón Health Research Institute (IIS Aragón), Campus San Francisco Sq., 50009, Zaragoza, Spain., Anel A; Apoptosis, Immunity and Cancer Group, Department of Biochemistry and Molecular and Cell Biology, Faculty of Sciences, University of Zaragoza and Aragón Health Research Institute (IIS Aragón), Campus San Francisco Sq., 50009, Zaragoza, Spain. anel@unizar.es., Villalba M; IRMB, Univ Montpellier, INSERM, Montpellier, France. martin.villalba@inserm.fr.; CNRS, IRMB, INSERM, Univ Montpellier, CHU Montpellier, Montpellier, France. martin.villalba@inserm.fr.; Institut Sainte Catherine, Avignon, France. martin.villalba@inserm.fr.

Publikováno v: Scientific reports [Sci Rep] 2022 Jan 25; Vol. 12 (1), pp. 1341. Date of Electronic Publication: 2022 Jan 25.

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