Výsledky vyhledávání - "Coen A. Ottenheijm"

Super relaxed myosins loosen up to different cues in cardiac and skeletal muscle sarcomeres

Autor: Wout J. Claassen, Coen A.C. Ottenheijm

Publikováno v: The Journal of general physiology, 155(7). Rockefeller University Press
Claassen, W J & Ottenheijm, C A C 2023, ' Super relaxed myosins loosen up to different cues in cardiac and skeletal muscle sarcomeres ', The Journal of general physiology, vol. 155, no. 7 . https://doi.org/10.1085/jgp.202213292

Recent papers by Nelson et al. and Pilagov et al. provide important new information on the ever-expanding role of myosin heads in the regulation of contraction.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::380c9c5282edf02a1a14703bcf3f37ef
https://research.vumc.nl/en/publications/255f0913-4d0b-4a16-99ef-0b41d91c060b

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Skeletal myopathy in a rat model of postmenopausal heart failure with preserved ejection fraction

Autor: Coen A.C. Ottenheijm, Suzanne C. Brinson, Dongwoo Hahn, Shengyi Shen, Rachel C. Kelley, Eliza Balazic, Ravi A. Kumar, Leonardo F. Ferreira, Nuria Curbello-Bermudez, Andrea M. Noriega, Robbert van der Pijl, Terence E. Ryan, Lauren Betancourt, Derek R. Muscato

Publikováno v: J Appl Physiol (1985)
Journal of Applied Physiology, 132(1), 106-125. American Physiological Society
Kelley, R C, Betancourt, L, Noriega, A M, Brinson, S C, Curbelo-Bermudez, N, Hahn, D, Kumar, R A, Balazic, E, Muscato, D R, Ryan, T E, van der Pijl, R J, Shen, S, Ottenheijm, C A C & Ferreira, L F 2022, ' Skeletal myopathy in a rat model of postmenopausal heart failure with preserved ejection fraction ', Journal of Applied Physiology, vol. 132, no. 1, pp. 106-125 . https://doi.org/10.1152/japplphysiol.00170.2021

Heart failure with preserved ejection fraction (HFpEF) accounts for ∼50% of all patients with heart failure and frequently affects postmenopausal women. The HFpEF condition is phenotype-specific, with skeletal myopathy that is crucial for disease d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47282fafc1a5f342d68f41a66167872f
https://pubmed.ncbi.nlm.nih.gov/34792407

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The titin N2B and N2A regions: biomechanical and metabolic signaling hubs in cross-striated muscles

Autor: Elisabeth Ehler, Robbert van der Pijl, Farah Sheikh, Coen A.C. Ottenheijm, Stephan Lange, Andrea A. Domenighetti

Publikováno v: Biophysical Reviews

Muscle specific signaling has been shown to originate from myofilaments and their associated cellular structures, including the sarcomeres, costameres or the cardiac intercalated disc. Two signaling hubs that play important biomechanical roles for ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd38acaafd45064adf32ca9a0f53bb2
https://doi.org/10.1007/s12551-021-00836-3

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Intraoperative phrenic stimulation offsets diaphragm fiber weakness during cardiothoracic surgery

Autor: Guilherme Bresciani, Thomas Beaver, A. Daniel Martin, Robbert van der Pijl, Robert Mankowski, Christiaan Leeuwenburgh, Coen A.C. Ottenheijm, Tomas Martin, George Arnaoutakis, Shakeel Ahmed, Vinicius Mariani, Wei Xue, Barbara K. Smith, Leonardo F. Ferreira

RationaleMechanical ventilation rapidly induces slow and fast fiber contractile dysfunction in the human diaphragm, which could be attenuated by phrenic nerve stimulation. Here, we present data from a controlled trial of intraoperative phrenic stimul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed3bd379ec0d729e96f48201d75d36f2
https://doi.org/10.1101/2022.09.16.22279894

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Molecular Mechanisms of Diaphragm Myopathy in Humans with Severe Heart Failure

Autor: Edoardo Malfatti, Jennifer Hommel, Volker Adams, Joanna Jozwiak-Nozdrzykowska, Clara Schmitz, Jens Garbade, Ephraim B. Winzer, Sven Lehmann, Anna L. Meyer, Michael Schwarzer, Marloes van den Berg, Coen A.C. Ottenheijm, Axel Linke, Norman Mangner, E. Heyne, T. Scott Bowen, Marcus Sandri

Publikováno v: Circulation Research, 128(6), 706-719. Lippincott Williams and Wilkins
Mangner, N, Garbade, J, Heyne, E, van den Berg, M, Winzer, E B, Hommel, J, Sandri, M, Jozwiak-Nozdrzykowska, J, Meyer, A L, Lehmann, S, Schmitz, C, Malfatti, E, Schwarzer, M, Ottenheijm, C A C, Bowen, T S, Linke, A & Adams, V 2021, ' Molecular Mechanisms of Diaphragm Myopathy in Humans with Severe Heart Failure ', Circulation Research, vol. 128, no. 6, pp. 706-719 . https://doi.org/10.1161/CIRCRESAHA.120.318060

Rationale: Diaphragm weakness impairs quality of life, exercise capacity, and survival in patients with chronic heart failure (CHF) and reduced left ventricular ejection fraction. However, the underlying cellular mechanisms responsible in humans rema

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d88fff17d26938d0b9f22ed8c221f50
http://www.scopus.com/inward/record.url?scp=85103229044&partnerID=8YFLogxK

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Novel ACTA1 mutation causes late-presenting nemaline myopathy with unusual dark cores

Autor: Enrico Bertini, Elisabetta Bucci, Giovanni Antonini, Luca Leonardi, Marco Salvetti, Bas Uijterwijk, Antonella Stoppacciaro, Martijn Zierikzee, Salvatore Raffa, Fiammetta Vanoli, Tommaso Tartaglione, Laura Fionda, Elena Maria Pennisi, Gioia Merlonghi, Fabiana Fattori, Coen A.C. Ottenheijm, Matteo Garibaldi, Stefania Morino, Andrea Micaloni

Publikováno v: Garibaldi, M, Fattori, F, Pennisi, E M, Merlonghi, G, Fionda, L, Vanoli, F, Leonardi, L, Bucci, E, Morino, S, Micaloni, A, Tartaglione, T, Uijterwijk, B, Zierikzee, M, Ottenheijm, C, Bertini, E S, Stoppacciaro, A, Raffa, S, Salvetti, M & Antonini, G 2021, ' Novel ACTA1 mutation causes late-presenting nemaline myopathy with unusual dark cores ', Neuromuscular Disorders, vol. 31, no. 2, pp. 139-148 . https://doi.org/10.1016/j.nmd.2020.11.012
Neuromuscular Disorders, 31(2), 139-148. Elsevier Limited

ACTA1 gene encodes the skeletal muscle alpha-actin, the core of thin filaments of the sarcomere. ACTA1 mutations are responsible of several muscle disorders including nemaline, cores, actin aggregate myopathies and fiber-type disproportion. We report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21e22653de2aba26bdf9cdf178ab20f3
https://doi.org/10.1016/j.nmd.2020.11.012

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Triggering typical nemaline myopathy with compound heterozygous nebulin mutations reveals myofilament structural changes as pathomechanism

Autor: Thomas C. Irving, Zaynab Hourani, John E. Smith, Weikang Ma, Paola Tonino, Johan Lindqvist, Josh Strom, Henk Granzier, Frank Li, Coen A.C. Ottenheijm, Esmat Karimi, Henry Gong, Robbert van der Pijl, Yaeren Hernandez, Balázs Kiss, Justin Kolb

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications, 11(1):2699. Nature Publishing Group UK
Lindqvist, J, Ma, W, Li, F, Hernandez, Y, Kolb, J, Kiss, B, Tonino, P, van der Pijl, R, Karimi, E, Gong, H, Strom, J, Hourani, Z, Smith, J E, Ottenheijm, C A C, Irving, T & Granzier, H 2020, ' Triggering typical nemaline myopathy with compound heterozygous nebulin mutations reveals myofilament structural changes as pathomechanism ', Nature Communications, vol. 11, no. 1, 2699 . https://doi.org/10.1038/s41467-020-16526-9
Nature Communications

Nebulin is a giant protein that winds around the actin filaments in the skeletal muscle sarcomere. Compound-heterozygous mutations in the nebulin gene (NEB) cause typical nemaline myopathy (NM), a muscle disorder characterized by muscle weakness with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158f7f53cf1a448aeb85bc5d60978071
http://link.springer.com/article/10.1038/s41467-020-16526-9

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