A driver role for GABA metabolism in controlling stem and proliferative cell state through GHB production in glioma

Autor: El-Habr, Elias A., Dubois, Luiz G., Burel-Vandenbos, Fanny, Bogeas, Alexandra, Lipecka, Joanna, Turchi, Laurent, Lejeune, François-Xavier, Coehlo, Paulo Lucas Cerqueira, Yamaki, Tomohiro, Wittmann, Bryan M., Fareh, Mohamed, Mahfoudhi, Emna, Janin, Maxime, Narayanan, Ashwin, Morvan-Dubois, Ghislaine, Schmitt, Charlotte, Verreault, Maité, Oliver, Lisa, Sharif, Ariane, Pallud, Johan, Devaux, Bertrand, Puget, Stéphanie, Korkolopoulou, Penelope, Varlet, Pascale, Ottolenghi, Chris, Plo, Isabelle, Moura-Neto, Vivaldo, Virolle, Thierry, Chneiweiss, Hervé, Junier, Marie-Pierre

Publikováno v: Acta Neuropathologica
Acta Neuropathologica, Springer Verlag, 2016, 133 (4), pp.645-660. ⟨10.1007/s00401-016-1659-5⟩
Acta Neuropathologica, 133(4)
Acta Neuropathologica, Springer Verlag, 2016, 133 (4), pp.645-660. 〈10.1007/s00401-016-1659-5〉
Acta Neuropathologica, 2017, 133 (4), pp.645-660. ⟨10.1007/s00401-016-1659-5⟩

Cell populations with differing proliferative, stem-like and tumorigenic states co-exist in most tumors and especially malignant gliomas. Whether metabolic variations can drive this heterogeneity by controlling dynamic changes in cell states is unkno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e0a2ae13eae9b81227ea7e26b107970d
https://www.hal.inserm.fr/inserm-01481051