Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Cody Krivacic"'
Autor:
Cody Krivacic, Kale Kundert, Xingjie Pan, Roland A. Pache, Lin Liu, Shane O Conchúir, Jeliazko R. Jeliazkov, Jeffrey J. Gray, Michael C. Thompson, James S. Fraser, Tanja Kortemme
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 11
Significance Computational protein design promises to advance applications in medicine and biotechnology by creating proteins with many new and useful functions. However, new functions require the design of specific and often irregular atom-level geo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e17a02cd4f0e5e7311d3e1aad566623
https://escholarship.org/uc/item/3452f0h6
https://escholarship.org/uc/item/3452f0h6
Autor:
Cody Krivacic, Michael C. Thompson, Roland A. Pache, Kale Kundert, Xingjie Pan, Tanja Kortemme, Lin Liu, James S. Fraser, Jeffrey J. Gray, Jeliazko R. Jeliazkov, Shane Ó Conchúir
Accurate positioning of functional residues is critical for the design of new protein functions, but has remained difficult because of the prevalence of irregular local geometries in active sites. Here we introduce two computational methods that buil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dadf9ee1c54768e444e02d750bf9d7d
https://doi.org/10.1101/2021.07.02.450934
https://doi.org/10.1101/2021.07.02.450934
Autor:
Michael C. Thompson, Tanja Kortemme, Daniel J. Mandell, Kyle A. Barlow, Jenna Pellegrino, Yao-Ming Huang, James S. Fraser, Amanda L. Loshbaugh, Anum A. Glasgow, Noah Ollikainen, Mark J. S. Kelly, Ryan Ritterson, Cody Krivacic, Deborah Jeon, Roland A. Pache
Publikováno v:
Science
Science (New York, N.Y.), vol 366, iss 6468
Science (New York, N.Y.), vol 366, iss 6468
Sense and respond Many signaling pathways start with cellular proteins sensing and responding to small molecules. Despite advances in protein design, creating a protein-based sense-and-respond system remains challenging. Glasgow et al. designed bindi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf3b5ab92ce33debbe89d63e90254e35
https://europepmc.org/articles/PMC7343396/
https://europepmc.org/articles/PMC7343396/
Autor:
Michael R. Collins, Robert Steven Kania, Connie Fan, Sutton Scott Channing, Dominique Verhelle, Kephart Susan Elizabeth, Martin James Wythes, Shuiwang Wang, Karen A. Maegley, Lisa Nguyen, Daniel Tyler Richter, A.E. Stewart, Pei-Pei Kung, Buwen Huang, Shikhar Sharma, Shinji Yamazaki, Ya-Li Deng, Rita Grantner, Patrick Bingham, Robert Arnold Kumpf, Penney Khamphavong, Jinjiang Zhu, Dac M. Dinh, Manfred Kraus, Wei Liu, Sean Uryu, Jillian E. Spangler, Wenyue Hu, Hui Wang, Robert A. Rollins, Cody Krivacic, Zehnder Luke Raymond, Neal W. Sach, Alexei Brooun, John Sherrill, Shijian Ren, Martin A. Edwards, Huichun Zhu, Ketan S. Gajiwala, Shuibo Xin, Hovhannes J. Gukasyan
Publikováno v:
Journal of Medicinal Chemistry. 61:650-665
A new series of lactam-derived EZH2 inhibitors was designed via ligand-based and physicochemical-property-based strategies to address metabolic stability and thermodynamic solubility issues associated with previous lead compound 1. The new inhibitors
Autor:
Pei-Pei, Kung, Patrick, Bingham, Alexei, Brooun, Michael, Collins, Ya-Li, Deng, Dac, Dinh, Connie, Fan, Ketan S, Gajiwala, Rita, Grantner, Hovhannes J, Gukasyan, Wenyue, Hu, Buwen, Huang, Robert, Kania, Susan E, Kephart, Cody, Krivacic, Robert A, Kumpf, Penney, Khamphavong, Manfred, Kraus, Wei, Liu, Karen A, Maegley, Lisa, Nguyen, Shijian, Ren, Dan, Richter, Robert A, Rollins, Neal, Sach, Shikhar, Sharma, John, Sherrill, Jillian, Spangler, Albert E, Stewart, Scott, Sutton, Sean, Uryu, Dominique, Verhelle, Hui, Wang, Shuiwang, Wang, Martin, Wythes, Shuibo, Xin, Shinji, Yamazaki, Huichun, Zhu, JinJiang, Zhu, Luke, Zehnder, Martin, Edwards
Publikováno v:
Journal of medicinal chemistry. 61(3)
A new series of lactam-derived EZH2 inhibitors was designed via ligand-based and physicochemical-property-based strategies to address metabolic stability and thermodynamic solubility issues associated with previous lead compound 1. The new inhibitors
Publikováno v:
ASSAY and Drug Development Technologies. 13:235-240
Conformational remodeling of chromatin in cells is known to alter gene expression. The histone code hypothesis postulates that multiple modifications present on histone tails can regulate gene expression both through direct effects on chromatin compa
Autor:
Patrick Bingham, Wade Diehl, Karen A. Maegley, Cody Krivacic, Buwen Huang, Zehnder Luke Raymond, Xiu Yu, Pei-Pei Kung, Tatlock John H, Ketan S. Gajiwala
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:1532-1537
A series of novel enhancer of zeste homolog 2 (EZH2) inhibitors was designed based on the chemical structure of the histone methyltransferase (HMT) inhibitor SAH (S-adenosyl-l-homocysteine). These nucleoside-based EZH2 inhibitors blocked the methylat
Autor:
Hovhannes J. Gukasyan, Michael R. Collins, Sutton Scott Channing, Kephart Susan Elizabeth, Shinji Yamazaki, Sacha Ninkovic, Simon Bergqvist, Fen Wang, Robert Arnold Kumpf, Michael Ryskin, Patrick Bingham, Pei-Pei Kung, Dominique Verhelle, Brian Yip, Karen A. Maegley, Robert A. Rollins, Peter A. Wells, Martha A. Ornelas, Buwen Huang, Valeria Fantin, Xiu Yu, Stephanie Scales, Wade Diehl, Indrawan James Mcalpine, Cody Krivacic, Mei Cui, Lisa Nguyen, Wenyue Hu, Tatlock John H, Dac M. Dinh, Martin James Wythes, Connie Fan, Gary Li, Martin Paul Edwards, Rui Eugene Yuanjin, John F. Braganza, Zehnder Luke Raymond, Wei-Guo Zhang
Publikováno v:
Journal of medicinal chemistry. 59(18)
A new enhancer of zeste homolog 2 (EZH2) inhibitor series comprising a substituted phenyl ring joined to a dimethylpyridone moiety via an amide linkage has been designed. A preferential amide torsion that improved the binding properties of the compou
Autor:
Pei-Pei Kung, Eugene Rui, Simon Bergqvist, Patrick Bingham, John Braganza, Michael Collins, Mei Cui, Wade Diehl, Dac Dinh, Connie Fan, Valeria R. Fantin, Hovhannes J. Gukasyan, Wenyue Hu, Buwen Huang, Susan Kephart, Cody Krivacic, Robert A. Kumpf, Gary Li, Karen A. Maegley, Indrawan McAlpine, Lisa Nguyen, Sacha Ninkovic, Martha Ornelas, Michael Ryskin, Stephanie Scales, Scott Sutton, John Tatlock, Dominique Verhelle, Fen Wang, Peter Wells, Martin Wythes, Shinji Yamazaki, Brian Yip, Xiu Yu, Luke Zehnder, Wei-Guo Zhang, Robert A. Rollins, Martin Edwards
Publikováno v:
Journal of Medicinal Chemistry. 59:11196-11196
Publikováno v:
Cancer Research. 74:5155-5155
Introduction: Histone methyltransferases (HMT's) are histone-modifying enzymes, that catalyze the transfer of one, two, or three methyl groups from S-adenosyl-L-methionine (SAM) to lysine and arginine residues on histone proteins. This methylation re