Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Cody J. Wehrkamp"'
Autor:
Sathish Kumar Natarajan, Bailey A. Stringham, Ashley M. Mohr, Cody J. Wehrkamp, Sizhao Lu, Mary Anne Phillippi, Dee Harrison-Findik, Justin L. Mott
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 5, Pp 866-875 (2017)
Nonalcoholic steatohepatitis (NASH) patients have elevated plasma saturated free fatty acid levels. These toxic fatty acids can induce liver cell death and our recent results demonstrated that the biliary epithelium may be susceptible to lipotoxicity
Externí odkaz:
https://doaj.org/article/a166e127fc9644ea9193a86b5553ff68
Autor:
Cody J. Wehrkamp, Andrew M. Oleksijew, Adrian P. Mansini, Sergio A. Gradilone, Ashley M. Mohr, Justin L. Mott
Cholangiocarcinoma is an aggressive solid tumor formed in the bile duct epithelium. Often this tumor obstructs bile flow, known as cholestasis. Normal cholangiocytes detect bile flow in the ductal lumen with an extension of the apical membrane called
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dde0fffb309059dbbd141b5431f6826
https://doi.org/10.1101/2023.03.01.530694
https://doi.org/10.1101/2023.03.01.530694
Autor:
Justin L. Mott, Duygu Dee Harrison-Findik, Sathish Kumar Natarajan, Ashley M. Mohr, Sizhao Lu, Bailey A. Stringham, Mary Anne Phillippi, Cody J. Wehrkamp
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 5, Pp 866-875 (2017)
Journal of Lipid Research
Journal of Lipid Research
Nonalcoholic steatohepatitis (NASH) patients have elevated plasma saturated free fatty acid levels. These toxic fatty acids can induce liver cell death and our recent results demonstrated that the biliary epithelium may be susceptible to lipotoxicity
Autor:
Steve Kachman, Ashley M. Mohr, Matthieu R. Spriet, Brandon Henslee, Justin L. Mott, Cody J. Wehrkamp
Publikováno v:
Cancer Research. 80:2518-2518
Cholangiocarcinoma, a primary liver cancer of the bile ducts, effects 6,000 patients yearly and incidence has been growing consistently over the past 15 years. Current therapies for cholangiocarcinoma are not curative and patient survival is less tha
Autor:
Justin L. Mott, Geoffrey A. Talmon, Yazhe Wang, Ashley M. Mohr, David Oupický, Mary Anne Phillippi, Cody J. Wehrkamp, Yi Chen, Ying Xie, Yu Hang, Lee Jaramillo, Jing Li
Publikováno v:
Theranostics
Cholangiocarcinoma (CCA) is the second most common primary liver malignancy with extremely poor therapeutic outcome due to high drug resistance, widespread metastasis and lack of effective treatment options. CCA progression and metastasis are regulat
Autor:
Mary Anne Phillippi, Ashley M. Mohr, Sathish Kumar Natarajan, Cody J. Wehrkamp, Justin L. Mott
MicroRNA dysregulation is a common feature of cancer and due to the promiscuity of microRNA binding this can result in a wide array of genes whose expression is altered. miR-106b is an oncomiR overexpressed in cholangiocarcinoma and its upregulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e7f58e2721fb74416793cb6e9e6b71
Autor:
Sathish Kumar Natarajan, Anuttoma Ray, Mary Anne Phillippi, Justin L. Mott, Sohini Roy, Ashley M. Mohr, Sophie C. Cazanave, Sally A. Ingham, Cody J. Wehrkamp
Publikováno v:
Hepatology. 60:1942-1956
Recent studies have identified a cholestatic variant of nonalcoholic fatty liver disease (NAFLD) with portal inflammation and ductular reaction. Based on reports of biliary damage, as well as increased circulating free fatty acids (FFAs) in NAFLD, we
Cholangiocarcinoma is the second most common primary liver malignancy with extremely poor prognosis due to early invasion and widespread metastasis. The invasion and metastasis are regulated by multiple factors including CXCR4 chemokine receptor and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af1ea182e70503373c6981402cf6a0a3
https://europepmc.org/articles/PMC4924348/
https://europepmc.org/articles/PMC4924348/
767 Inhibition of FGF19 Signaling Decreases Proliferation and Sensitizes Cholangiocytes to Apoptosis
Publikováno v:
Gastroenterology. 146:S-927
During the course of cholestatic liver diseases, cholangiocytes exhibit marked proliferative capacity followed by cholangiocyte loss. A hallmark feature of cholestasis is increased concentrations of serum bile acids. We have previously shown alterati
Autor:
Sathish Kumar Natarajan, Ashley R. Gutwein, Justin L. Mott, Mary Anne Phillippi, Cody J. Wehrkamp
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 3, p e90238 (2014)
PLoS ONE, Vol 9, Iss 3, p e90238 (2014)
Cholangiocarcinoma cells are dependent on antiapoptotic signaling for survival and resistance to death stimuli. Recent mechanistic studies have revealed that increased cellular expression of the E3 ubiquitin-protein ligase X-linked inhibitor of apopt