Zobrazeno 1 - 10
of 304
pro vyhledávání: '"Cody J. Peer"'
Autor:
Malin Hultcrantz, Hani Hassoun, Neha Korde, Kylee MacLachlan, Sham Mailankody, Dhwani Patel, Urvi A. Shah, Carlyn Rose Tan, David J. Chung, Oscar B. Lahoud, Heather J. Landau, Michael Scordo, Gunjan L. Shah, Sergio A. Giralt, Matthew J. Pianko, Miranda Burge, Kelly Barnett, Meghan Salcedo, Julia Caple, Linh Tran, Jenna Blaslov, Tala Shekarkhand, Selena Hamid, David Nemirovsky, Andriy Derkach, Oluwatobi Arisa, Cody J. Peer, William D. Figg, Saad Z. Usmani, Ola Landgren, Alexander M. Lesokhin
Publikováno v:
Blood Cancer Journal, Vol 14, Iss 1, Pp 1-5 (2024)
Externí odkaz:
https://doaj.org/article/fe04ce63af1445c2a54d5c8efb6e5ac9
Autor:
Unsun Lee, Ludmila Szabova, Victor J. Collins, Melanie Gordon, Kristine Johnson, Deborah Householder, Stephanie Jorgensen, Lucy Lu, Laura Bassel, Fathi Elloumi, Cody J. Peer, Ariana E. Nelson, Sophia Varriano, Sudhir Varma, Ryan D. Roberts, Zoe Weaver Ohler, William D. Figg, Shyam K. Sharan, Yves Pommier, Christine M. Heske
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
IntroductionThe topoisomerase 1 (TOP1) inhibitor irinotecan is a standard-of-care agent for relapsed Ewing sarcoma (EWS), but its efficacy is limited by chemical instability, rapid clearance and reversibility, and dose-limiting toxicities, such as di
Externí odkaz:
https://doaj.org/article/10caaca1b67e432ab0d7e84fc26b685f
Autor:
Nebojsa Skorupan, Cody J. Peer, Xianyu Zhang, Hyoyoung Choo-Wosoba, Mehwish I. Ahmad, Min-Jung Lee, Shraddha Rastogi, Nahoko Sato, Yunkai Yu, Guillaume Joe Pegna, Seth M. Steinberg, Shelley S. Kalsi, Liang Cao, William D. Figg, Jane B. Trepel, Ira Pastan, David FitzGerald, Christine Alewine
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundLMB-100 is a mesothelin (MSLN)-targeting recombinant immunotoxin (iTox) carrying a Pseudomonas exotoxin A payload that has shown promise against solid tumors, however, efficacy is limited by the development of neutralizing anti-drug antibod
Externí odkaz:
https://doaj.org/article/7b50e02d4e8d4d54b44bd8cfb4b2d620
Autor:
Guillaume Joe Pegna, Min‐Jung Lee, Cody J. Peer, Mehwish I. Ahmad, David J. Venzon, Yunkai Yu, Akira Yuno, Seth M. Steinberg, Liang Cao, William D. Figg, Renee N. Donahue, Raffit Hassan, Ira Pastan, Jane B. Trepel, Christine Alewine
Publikováno v:
Cancer Medicine, Vol 12, Iss 4, Pp 4236-4249 (2023)
Abstract LMB‐100 is a novel immune‐conjugate (immunotoxin) that targets mesothelin. A phase 1/2 clinical trial was conducted (NCT02810418) with primary objectives assessing the safety and efficacy of LMB‐100 ± nab‐paclitaxel. Participant blo
Externí odkaz:
https://doaj.org/article/b0426dc9f76e4ee5ac65fe73a10166c9
Autor:
Ashlyn Parkhurst, Sabrina Z. Wang, Tyler R. Findlay, Kristen J. Malebranche, Arman Odabas, Jesse Alt, Micah J. Maxwell, Harpreet Kaur, Cody J. Peer, William D. Figg, Katherine E. Warren, Barbara S. Slusher, Charles G. Eberhart, Eric H. Raabe, Jeffrey A. Rubens
Publikováno v:
Cell Death and Disease, Vol 13, Iss 4, Pp 1-14 (2022)
Abstract Atypical teratoid/rhabdoid tumors (AT/RT) are the most common malignant brain tumors of infancy and have a dismal 4-year event-free survival (EFS) of 37%. We have previously shown that mTOR activation contributes to AT/RT’s aggressive grow
Externí odkaz:
https://doaj.org/article/10b90ebb273a45c786ac0a49aa2935b6
Autor:
Bih-Rong Wei, Cody J. Peer, William J. Richardson, Stephen M. Hewitt, William D. Figg, R. Mark Simpson
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
Activation of one or both the Ras/MAPK and PI3K/Akt/mTOR signal transduction pathways are known to mediate oncogenicity of several canine and human cancers, including mucosal melanomas. Reciprocal cross activation between the two pathways can be a so
Externí odkaz:
https://doaj.org/article/b3aa62de85994eb88e051c19e87a5dbd
Autor:
Xianyu Zhang, Yunkai Yu, Cody J. Peer, Rebekah Landsman, Nebojsa Skorupan, Liang Cao, Christine Alewine
Publikováno v:
Translational Oncology, Vol 21, Iss , Pp 101440- (2022)
Mesothelin (MSLN) is overexpressed by many cancers, including pancreatic ductal adenocarcinoma (PDAC) and has consequently become a target for anti-cancer therapeutics. Mature, membrane bound MSLN is cleaved by proteases, releasing a shed form that t
Externí odkaz:
https://doaj.org/article/9fd8099ceea94d9b9d4c45b0e8b8941a
Autor:
Brunilde Gril, Anurag N. Paranjape, Stephan Woditschka, Emily Hua, Emma L. Dolan, Jeffrey Hanson, Xiaolin Wu, Wojciech Kloc, Ewa Izycka-Swieszewska, Renata Duchnowska, Rafał Pęksa, Wojciech Biernat, Jacek Jassem, Naema Nayyar, Priscilla K. Brastianos, O. Morgan Hall, Cody J. Peer, William D. Figg, Gary T. Pauly, Christina Robinson, Simone Difilippantonio, Emilie Bialecki, Philippe Metellus, Joel P. Schneider, Patricia S. Steeg
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
When brain metastases form, the blood–brain barrier morphs into the blood–tumor barrier (BTB), surrounded by neuroinflammatory response. Here, the authors show that S1P3 is upregulated in neuroinflammatory response in highly BTB permeable lesions
Externí odkaz:
https://doaj.org/article/69cb9612d00a46d3a48171a71ecd0d7b
Autor:
Dante A. Suffredini, Jung-Min Lee, Cody J. Peer, Drew Pratt, David E. Kleiner, Jason M. Elinoff, Michael A. Solomon
Publikováno v:
BMC Pulmonary Medicine, Vol 18, Iss 1, Pp 1-7 (2018)
Abstract Background Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare cause of pulmonary hypertension that is associated with malignancies and is marked by the presence of non-occlusive tumor emboli and fibrocellular intimal proliferation o
Externí odkaz:
https://doaj.org/article/27ff15e62be14526bff4dd38f8c6af0d
Autor:
Jin Wang, Bertrand Z. Yeung, M. Guillaume Wientjes, Minjian Cui, Cody J. Peer, Ze Lu, William D. Figg, Sukyung Woo, Jessie L.-S. Au
Publikováno v:
Pharmaceutics, Vol 13, Iss 7, p 997 (2021)
Exosomes, naturally occurring vesicles secreted by cells, are undergoing development as drug carriers. We used experimental and computational studies to investigate the kinetics of intracellular exosome processing and exosome-mediated drug efflux and
Externí odkaz:
https://doaj.org/article/eafa1fff3c4641eaa643cb4240fc6d8c