Výsledky vyhledávání - "Cody J. Lensing"

Risk Factors Associated with COVID-19 Hospitalization and Mortality: A Large Claims-Based Analysis Among People with Type 2 Diabetes Mellitus in the United States

Autor: Cody J. Lensing, Kristina S. Boye, Elif Tokar Erdemir, Robert J. Heine, Scott Sailer, Ramira San Juan, Abraham Reddy, Brian D. Benneyworth, Nathan D. Zimmerman, Emily R. Hankosky, Lida Etemad, Matan C. Dabora, Callahan Clark, M. Angelyn Bethel

Publikováno v: Diabetes Therapy

Introduction Diabetes has been identified as a high-risk comorbidity for COVID-19 hospitalization. We evaluated additional risk factors for COVID-19 hospitalization and in-hospital mortality in a nationwide US database. Methods This retrospective stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ec1e0b44463fb966805cb5a15d0551
http://europepmc.org/articles/PMC8286432

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Retrospective comparative study of the effectiveness of bariatric surgery on 3-year outcomes in the real-world clinical setting

Autor: Walter J. Pories, Suchit Mehrotra, Jejomar Derecho, Rossjyn Fallorina, Maria S. Altieri, Eric J. DeMaria, Cody J. Lensing, William Irish

Publikováno v: Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery. 18(2)

Bariatric surgery has shown an improvement in obesity and obesity-related disease in many clinical trials and single center studies. However, real-world data, including data from non-centers of excellence, is sparse.To provide clinical outcomes of pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d666a2562996f4643b0552e07580ab39
https://pubmed.ncbi.nlm.nih.gov/35105512

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2180-PUB: Integration of Continuous Glucose Monitoring in Diabetes Self-Management Education for Type 2 Diabetes Improves Glycemic Control

Autor: Kimberly Luu, Kelly Barger, Athena Philis-Tsimikas, Laura Talavera, Addie L. Fortmann, Alessandra Bastian, Cody J. Lensing, Shane Hoversten

Publikováno v: Diabetes. 69

Continuous glucose monitors (CGM) are an integral aspect in the glucose management of many individuals with type 1 diabetes, and a growing number of people with insulin-requiring type 2 diabetes (T2D). A 2019 meta-analysis of 7 randomized controlled

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db0b0e57ab2ee2447368d65ba8f8094b
https://doi.org/10.2337/db20-2180-pub

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Empowering Patients and Providers With More and Better Data: Innovative Concepts in Type 2 Diabetes Management

Autor: Jared P. Jones, Ben W. Ehlert, Jessyca M. Duerr, Stephen R. Garth, Craig D. Wagner, Cody J. Lensing, Shane Hoversten, Kevin A. Kapov

Publikováno v: Diabetes Spectr

IN BRIEF In this article, the authors discuss several innovative concepts UnitedHealth Group Research & Development is exploring to help patients manage their type 2 diabetes. The article focuses on efforts to use remote support programs and wearable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bac5b6f12acabba4547607cef246100
https://pubmed.ncbi.nlm.nih.gov/31798290

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Discovery of Melanocortin Ligands via a Double Simultaneous Substitution Strategy Based on the Ac-His-dPhe-Arg-Trp-NH2 Template

Autor: Aleksandar Todorovic, Carrie Haskell-Luevano, Cody J. Lensing, Joseph W. Scott, Jerry Ryan Holder, Nicholas B. Sorensen

Publikováno v: ACS Chemical Neuroscience. 9:2753-2766

The melanocortin system regulates an array of diverse physiological functions including pigmentation, feeding behavior, energy homeostasis, cardiovascular regulation, sexual function, and steroidogenesis. Endogenous melanocortin agonist ligands all p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2b65d765430c9bfed8c7b0134c6f934
https://doi.org/10.1021/acschemneuro.8b00181

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Human β-Defensin 1 and β-Defensin 3 (Mouse Ortholog mBD14) Function as Full Endogenous Agonists at Select Melanocortin Receptors

Autor: Katie T. Freeman, Jay W. Schaub, Stacey L. Wilber, Carrie Haskell-Luevano, Cody J. Lensing, Marvin L. Dirain, Srinivasa R. Tala, Viktor Flores, Mark D. Ericson, Erica M. Haslach, Branden A. Smeester, Robert C. Speth, Natalie Eick, Anamika Singh, Danielle N. Adank

Publikováno v: Journal of Medicinal Chemistry. 61:3738-3744

β-Defensin 3 (BD3) was identified as a ligand for the melanocortin receptors (MCRs) in 2007, although the pharmacology activity of BD3 has not been clearly elucidated. Herein, it is demonstrated that human BD3 and mouse BD3 are full micromolar agoni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8841371d1b4bc5a5b7bca6f8012e9077
https://doi.org/10.1021/acs.jmedchem.8b00251

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1,2,3-Triazole Rings as a Disulfide Bond Mimetic in Chimeric AGRP-Melanocortin Peptides: Design, Synthesis, and Functional Characterization

Autor: James R. Rocca, Katie T. Freeman, Sathya M. Schnell, Carrie Haskell-Luevano, Srinivasa R. Tala, Anamika Singh, Cody J. Lensing

Publikováno v: ACS Chemical Neuroscience. 9:1001-1013

The melanocortin system is involved in the regulation of complex physiological functions, including energy and weight homeostasis, feeding behavior, inflammation, sexual function, pigmentation, and exocrine gland function. The five melanocortin recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b59543bdfa43bbbdc613269c4ad6c348
https://doi.org/10.1021/acschemneuro.7b00422

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Bench-top to clinical therapies: A review of melanocortin ligands from 1954 to 2016

Autor: Mark D. Ericson, Katherine N. Schlasner, Cody J. Lensing, Skye R. Doering, Carrie Haskell-Luevano, Katlyn A. Fleming

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1863:2414-2435

The discovery of the endogenous melanocortin agonists in the 1950s have resulted in sixty years of melanocortin ligand research. Early efforts involved truncations or select modifications of the naturally occurring agonists leading to the development

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d42f9775ea1ecb7c80fb052a054758
https://doi.org/10.1016/j.bbadis.2017.03.020

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A Direct in Vivo Comparison of the Melanocortin Monovalent Agonist Ac-His-DPhe-Arg-Trp-NH2 versus the Bivalent Agonist Ac-His-DPhe-Arg-Trp-PEDG20-His-DPhe-Arg-Trp-NH2: A Bivalent Advantage

Autor: Danielle N. Adank, Katie T. Freeman, Sathya M. Schnell, Carrie Haskell-Luevano, Cody J. Lensing, Stacey L. Wilber, Adam T. Zarth, Robert C. Speth

Publikováno v: ACS Chemical Neuroscience. 8:1262-1278

Bivalent ligands targeting putative melanocortin receptor dimers have been developed and characterized in vitro; however, studies of their functional in vivo effects have been limited. The current report compares the effects of homobivalent ligand CJ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf822f5056ea058ee2e6a891d1302b54
https://doi.org/10.1021/acschemneuro.6b00399

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