Zobrazeno 1 - 10
of 243
pro vyhledávání: '"Codon pair"'
Autor:
Sarah E. Fumagalli, Sean Smith, Tigran Ghazanchyan, Douglas Meyer, Rahul Paul, Collin Campbell, Luis Santana-Quintero, Anton Golikov, Juan Ibla, Haim Bar, Anton A. Komar, Ryan C. Hunt, Brian Lin, Michael DiCuccio, Chava Kimchi-Sarfaty
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract Mouse (Mus musculus) models have been heavily utilized in developmental biology research to understand mammalian embryonic development, as mice share many genetic, physiological, and developmental characteristics with humans. New exploration
Externí odkaz:
https://doaj.org/article/4ba89a888fe44f0d801eb3f593533bc8
Autor:
Nuri K. Hegelmeyer, Lia A. Parkin, Mary L. Previti, Joshua Andrade, Raditya Utama, Richard J. Sejour, Justin Gardin, Stephanie Muller, Steven Ketchum, Alisa Yurovsky, Bruce Futcher, Sara Goodwin, Beatrix Ueberheide, Jessica C. Seeliger
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Each genome encodes some codons more frequently than their synonyms (codon usage bias), but codons are also arranged more frequently into specific pairs (codon pair bias). Recoding viral genomes and yeast or bacterial genes with non-optimal
Externí odkaz:
https://doaj.org/article/1542f6e057564754a530c5177eff6b3d
Akademický článek
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Publikováno v:
Microbial Cell Factories, Vol 20, Iss 1, Pp 1-10 (2021)
Abstract Background Codon optimization is a common method to improve protein expression levels in Pichia pastoris and the current strategy is to replace rare codons with preferred codons to match the codon usage bias. However, codon-pair contexts hav
Externí odkaz:
https://doaj.org/article/bfca9fcb1ebe40f795be5736a7ce732f
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 4376-4380 (2022)
Research with infectious SARS-CoV-2 is complicated because it must be conducted under biosafety level 3 (BSL-3) conditions. Recently, we constructed a live attenuated SARS-CoV-2 virus by rational design through partial recoding of the SARS-CoV-2 geno
Externí odkaz:
https://doaj.org/article/e02598ba1c2a43c6ab7355566cc42792
Autor:
Douglas Meyer, Jacob Kames, Haim Bar, Anton A. Komar, Aikaterini Alexaki, Juan Ibla, Ryan C. Hunt, Luis V. Santana-Quintero, Anton Golikov, Michael DiCuccio, Chava Kimchi-Sarfaty
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-18 (2021)
Abstract Background Gene expression is highly variable across tissues of multi-cellular organisms, influencing the codon usage of the tissue-specific transcriptome. Cancer disrupts the gene expression pattern of healthy tissue resulting in altered co
Externí odkaz:
https://doaj.org/article/c7ca96719b204fc496ee0de68b57825b
Autor:
Gisselle N. Medina, Edward Spinard, Paul A. Azzinaro, Monica Rodriguez-Calzada, Joseph Gutkoska, Anna Kloc, Elizabeth A. Rieder, Bruce E. Taillon, Stephen Mueller, Teresa de los Santos, Fayna Diaz-San Segundo
Publikováno v:
Viruses, Vol 15, Iss 6, p 1332 (2023)
Foot-and-mouth disease (FMD), caused by the FMD virus (FMDV), is a highly contagious disease of cloven-hoofed livestock that can have severe economic impacts. Control and prevention strategies, including the development of improved vaccines, are urge
Externí odkaz:
https://doaj.org/article/d1b9122ebe054f7f92f32ace88ff628e
Autor:
Min-A Lee, Su-Hwa You, Usharani Jayaramaiah, Eun-Gyeong Shin, Seung-Min Song, Lanjeong Ju, Seok-Jin Kang, Sun-Hee Cho, Bang-Hun Hyun, Hyang-Sim Lee
Publikováno v:
Viruses, Vol 15, Iss 5, p 1071 (2023)
Porcine reproductive and respiratory syndrome virus (PRRSV) is major economic problem given its effects on swine health and productivity. Therefore, we evaluated the genetic stability of a codon pair de-optimized (CPD) PRRSV, E38-ORF7 CPD, as well as
Externí odkaz:
https://doaj.org/article/c8513efb66694d76a887b1be67a26e30
Autor:
Akito Taneda, Kiyoshi Asai
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 1811-1818 (2020)
Codon optimization in protein-coding sequences (CDSs) is a widely used technique to promote the heterologous expression of target genes. In codon optimization, a combinatorial space of nucleotide sequences that code a given amino acid sequence and ta
Externí odkaz:
https://doaj.org/article/d830716adb054c80969c17454e517f30
Autor:
Min-A Lee, Su-Hwa You, Usharani Jayaramaiah, Eun-Gyeong Shin, Seung-Min Song, Lanjeong Ju, Seok-Jin Kang, Sun Hee Cho, Bang-Hun Hyun, Hyang-Sim Lee
Publikováno v:
Vaccines, Vol 11, Iss 4, p 777 (2023)
Commercially used porcine respiratory and reproductive syndrome (PRRS) modified live virus (MLV) vaccines provide limited protection with heterologous viruses, can revert back to a virulent form and they tend to recombine with circulating wild-type s
Externí odkaz:
https://doaj.org/article/271bac1fbc7148e5a0059ab240ad2844