Astrocyte-Mediated Neuronal Synchronization Properties Revealed by False Gliotransmitter Release

Autor: Pirttimaki TM, Sims RE, Saunders G, Antonio SA, Codadu NK, Parri HR

Astrocytes spontaneously release glutamate (Glut) as a gliotransmitter (GT), resulting in the generation of extrasynaptic NMDAR-mediated slow inward currents (SICs) in neighboring neurons, which can increase local neuronal excitability. However, ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3891::6e17ec58982e849329fdfcf4fe420137
https://erepo.uef.fi/handle/123456789/5746

Indirect Effects of Halorhodopsin Activation: Potassium Redistribution, Nonspecific Inhibition, and Spreading Depolarization.

Autor: Parrish RR; Newcastle University Biosciences Institute, Medical School, Newcastle upon Tyne, NE2 4HH, United Kingdom.; Department of Cell Biology and Physiology, Brigham Young University, Provo 84602, Utah., MacKenzie-Gray Scott C; Newcastle University Biosciences Institute, Medical School, Newcastle upon Tyne, NE2 4HH, United Kingdom., Jackson-Taylor T; Newcastle University Biosciences Institute, Medical School, Newcastle upon Tyne, NE2 4HH, United Kingdom., Grundmann A; Newcastle University Biosciences Institute, Medical School, Newcastle upon Tyne, NE2 4HH, United Kingdom., McLeod F; Newcastle University Biosciences Institute, Medical School, Newcastle upon Tyne, NE2 4HH, United Kingdom., Codadu NK; Queen Square Institute of Neurology, University College London, WC1N 3BG, United Kingdom., Călin A; Newcastle University Biosciences Institute, Medical School, Newcastle upon Tyne, NE2 4HH, United Kingdom., Alfonsa H; Newcastle University Biosciences Institute, Medical School, Newcastle upon Tyne, NE2 4HH, United Kingdom., Wykes RC; Nanomedicine Lab, University of Manchester, Manchester, M13 9PL, United Kingdom.; Queen Square Institute of Neurology, University College London, WC1N 3BG, United Kingdom., Voipio J; Faculty of Biological and Environmental Sciences, Molecular and Integrative Biosciences, University of Helsinki, Helsinki, 00014, Finland., Trevelyan AJ; Newcastle University Biosciences Institute, Medical School, Newcastle upon Tyne, NE2 4HH, United Kingdom andrew.trevelyan@ncl.ac.uk.

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2023 Feb 01; Vol. 43 (5), pp. 685-692. Date of Electronic Publication: 2022 Dec 09.

Xenon LFP Analysis Platform Is a Novel Graphical User Interface for Analysis of Local Field Potential From Large-Scale MEA Recordings.

Autor: Mahadevan A; Department of Cellular and Molecular Biology, Xenon Pharmaceuticals Inc., Burnaby, BC, Canada., Codadu NK; Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London, United Kingdom., Parrish RR; Department of Cellular and Molecular Biology, Xenon Pharmaceuticals Inc., Burnaby, BC, Canada.

Publikováno v: Frontiers in neuroscience [Front Neurosci] 2022 Jul 01; Vol. 16, pp. 904931. Date of Electronic Publication: 2022 Jul 01 (Print Publication: 2022).

Excitatory GABAergic signalling is associated with benzodiazepine resistance in status epilepticus.

Autor: Burman RJ; Division of Cell Biology, Department of Human Biology, Neuroscience Institute and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.; Department of Paediatric Neurology, Red Cross War Memorial Children's Hospital, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.; Department of Pharmacology, University of Oxford, Oxford, UK., Selfe JS; Division of Cell Biology, Department of Human Biology, Neuroscience Institute and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Lee JH; Division of Cell Biology, Department of Human Biology, Neuroscience Institute and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., van den Berg M; Division of Cell Biology, Department of Human Biology, Neuroscience Institute and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Calin A; Department of Pharmacology, University of Oxford, Oxford, UK., Codadu NK; Institute of Neuroscience, Medical School, Framlington Place, Newcastle upon Tyne, NE24HH, UK., Wright R; Department of Pharmacology, University of Oxford, Oxford, UK., Newey SE; Department of Pharmacology, University of Oxford, Oxford, UK., Parrish RR; Institute of Neuroscience, Medical School, Framlington Place, Newcastle upon Tyne, NE24HH, UK., Katz AA; Division of Medical Biochemistry, Department of Integrated Biomedical Sciences and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Wilmshurst JM; Department of Paediatric Neurology, Red Cross War Memorial Children's Hospital, Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Akerman CJ; Department of Pharmacology, University of Oxford, Oxford, UK., Trevelyan AJ; Institute of Neuroscience, Medical School, Framlington Place, Newcastle upon Tyne, NE24HH, UK., Raimondo JV; Division of Cell Biology, Department of Human Biology, Neuroscience Institute and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Publikováno v: Brain : a journal of neurology [Brain] 2019 Nov 01; Vol. 142 (11), pp. 3482-3501.

Feedforward inhibition ahead of ictal wavefronts is provided by both parvalbumin- and somatostatin-expressing interneurons.

Autor: Parrish RR; Institute of Neuroscience, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK., Codadu NK; Institute of Neuroscience, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK., Mackenzie-Gray Scott C; Institute of Neuroscience, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK., Trevelyan AJ; Institute of Neuroscience, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

Publikováno v: The Journal of physiology [J Physiol] 2019 Apr; Vol. 597 (8), pp. 2297-2314. Date of Electronic Publication: 2019 Mar 18.