Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Coco N, Kapanda"'
Autor:
Hina N. Qureshi, Kenneth J. Sufka, Jussara M. do Carmo, Coco N. Kapanda, Hunter W. McLendon, Fernanda S. da Silva, John E. Hall, S. Stevens Negus, Jennifer E. Naylor, E. Andrew Townsend, Kevin B. Freeman, Shelley R. Edwards, Christopher R. McCurdy
Publikováno v:
Psychopharmacology. 234:2597-2605
Strategies to reduce the misuse of mu opioid agonists are critically needed. Previous work has shown that kappa opioid agonists can diminish the abuse-related effects and augment the antinociceptive effects of mu agonists. However, use of traditional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::821ca7c0f843f4d18e96eabdc6e182ef
https://doi.org/10.1007/s00213-017-4652-3
https://doi.org/10.1007/s00213-017-4652-3
Autor:
Joëlle Quetin-Leclercq, Mohamed Haddad, Cynthia Girardi, Marie-France Herent, Marieke Vansteelandt, Coco N. Kapanda, Valérie Jullian, Billy Cabanillas, Nicolas Fabre
Publikováno v:
Rapid Communications in Mass Spectrometry. 30:569-580
RATIONALE Hirsutinolide-type sesquiterpene lactones (SLs) are natural biologically active compounds mainly found in the genus Vernonia. Very few studies have been published about the fragmentation mechanisms of SLs generally and none about hirsutinol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13f9e35eb85af8fcafc7d7c6fc8eaed5
https://doi.org/10.1002/rcm.7473
https://doi.org/10.1002/rcm.7473
Autor:
Jacques H. Poupaert, Lamine Baba-Moussa, Joëlle Quetin-Leclercq, Fernand Gbaguidi, Georges C. Accrombessi, Emma W. Gachomo, Coco N. Kapanda, Simeon O. Kotchoni, Joanne Bero, Mansourou Moudachirou, Bienvenu Glinma, Sika D. S. Kpoviessi
Publikováno v:
Molecular Biology Reports. 41:1617-1622
Thiosemicarbazones have become one of the promising compounds as new clinical candidates due to their wide spectrum of pharmaceutical activities. The wide range of their biological activities depends generally on their related aldehyde or ketone grou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f806dc2fc24d78d8884e1fd61fb7eef2
https://doi.org/10.1007/s11033-013-3008-2
https://doi.org/10.1007/s11033-013-3008-2
Publikováno v:
Current Medicinal Chemistry. 20:1824-1846
Endocannabinoid hydrolases are nowadays increasingly considered as potential therapeutic targets for treating several pathological states. So far, numerous classes of endocannabinoid hydrolase inhibitors have been described. We herein review the medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c073c810bdd0c89b24c171d024136d8
https://doi.org/10.2174/09298673113209990108
https://doi.org/10.2174/09298673113209990108
Autor:
Didier M. Lambert, Jacques H. Poupaert, Coco N. Kapanda, Giulio G. Muccioli, Julien Masquelier, Geoffray Labar
Publikováno v:
Journal of Medicinal Chemistry. 55:5774-5783
Monoacylglycerol lipase (MAGL) is responsible for signal termination of 2-arachidonoylglycerol (2-AG), an endocannabinoid neurotransmitter endowed with several physiological effects. Previously, we showed that the arylthioamide scaffold represents a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16fe9fd0b94e1f737c2ffdcfc3d53aa4
https://doi.org/10.1021/jm3006004
https://doi.org/10.1021/jm3006004
Autor:
Fernand Gbaguidi, Hocine Aichaoui, Jacques H. Poupaert, Coco N. Kapanda, Christopher R. McCurdy
Publikováno v:
Medicinal Chemistry Research. 22:247-252
Based on a line of evidence (logP, pKa, 1 H-, and 13 C-NMR, and molecular modeling studies), it appears that cocaine undergoes a hydrophobic collapse which may account for its unprecedented ADME properties, in particular, its exceptional capacity to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75388db0907e5c565549fdbe7acdb172
https://doi.org/10.1007/s00044-012-0005-2
https://doi.org/10.1007/s00044-012-0005-2
Autor:
Faouzi Guenadil, Didier M. Lambert, Christopher R. McCurdy, Hocine Aichaoui, Jacques H. Poupaert, Coco N. Kapanda
Publikováno v:
Monatshefte für Chemie - Chemical Monthly. 142:67-80
A simpler and efficient “green” method using solid sodium hydroxide in a solvent mixture of acetone/water was found to catalyze N-acylation of 2(3H)-benzoxazolones and 2(3H)-benzothiazolones for facile and rapid synthesis of N-acyl derivatives in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76e7c58a6b8c84dcea3ab566c7da061e
https://doi.org/10.1007/s00706-010-0419-9
https://doi.org/10.1007/s00706-010-0419-9
Autor:
Sylvie De Bruyne, Filip De Vos, Geoffray Labar, Leonie Wyffels, Didier M. Lambert, Coco N. Kapanda, Giulio G. Muccioli
Publikováno v:
Nuclear Medicine and Biology. 37:665-675
Introduction: Fatty acid amide hydrolase (FAAH) is part of the endocannabinoid system (ECS) and has been linked to the aetiology of several neurological and neuropsychiatric disorders. So far no useful PET or SPECT tracer for in vivo visualisation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad3dc0abc664060cc68a6fc4f61459f5
https://doi.org/10.1016/j.nucmedbio.2010.03.009
https://doi.org/10.1016/j.nucmedbio.2010.03.009
Publikováno v:
Journal of Medicinal Chemistry. 52:7310-7314
Monoglyceride lipase (MGL) inhibition may offer an approach in treating diseases in which higher 2-arachidonoyglycerol activity would be beneficial. We report here the synthesis and pharmacological evaluation of bis(dialkylaminethiocarbonyl)disulfide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16383e5d7b4fa95e59f2a7fc63e74d9d
https://doi.org/10.1021/jm901323s
https://doi.org/10.1021/jm901323s
Synthesis and pharmacological evaluation of antioxidant chalcone derivatives of 2(3H)-benzoxazolones
Autor:
Coco N. Kapanda, Didier M. Lambert, Hocine Aichaoui, Jacques H. Poupaert, Faouzi Guenadil, Christopher R. McCurdy
Publikováno v:
Medicinal Chemistry Research. 18:467-476
Chalcones featuring an analgesic/anti-inflammatory pharmacophore, i.e., the 2(3H)-benzoxazolone heterocycle, on the one hand, and a radical scavenger moiety, i.e., 2,6-di-t-butylphenol, on the other hand were synthesized by condensation of a ketone 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb87027aa364506967542057fb207e62
https://doi.org/10.1007/s00044-008-9143-y
https://doi.org/10.1007/s00044-008-9143-y