Resolution of glycogen and glycogen-degrading activities reveals correlates of Lactobacillus crispatus dominance in a cohort of young African women

Autor: Karen V. Lithgow, Athena Cochinamogulos, Kevin Muirhead, Shaelen Konschuh, Lynda Oluoch, Nelly R. Mugo, Alison C. Roxby, Laura K. Sycuro

BackgroundA healthy vaginal microbiome is dominated by Lactobacillus species that produce lactic acid, lowering vaginal pH and limiting colonization by pathogens. Lactobacillus dominance (LD) is established during puberty, but many women, especially

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::92fec85c1c6d68df36471336c2b17a57
https://doi.org/10.1101/2022.03.29.486257

Glycogen-Degrading pullulanase a is variably present and correlated with lactic acid in vaginal samples from young african women

Autor: Sycuro L, Lithgow K, Cochinamogulos A, Muirhead K, Konschuh S, Oluoch L, Mugo N, Roxby A

Publikováno v: American Journal of Obstetrics and Gynecology. 228:S788

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09f11f59d044be2b9b9ab83bfe75a88c
https://doi.org/10.1016/j.ajog.2022.11.148

Bacterial amylases enable glycogen degradation by the vaginal microbiome.

Autor: Jenkins DJ; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Woolston BM; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Department of Chemical Engineering, Northeastern University, Boston, MA, USA., Hood-Pishchany MI; Division of Infectious Diseases and Division of Gastroenterology, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.; Department of Microbiology, Harvard Medical School, Boston, MA, USA., Pelayo P; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Konopaski AN; Department of Chemistry, Seattle University, Seattle, WA, USA., Quinn Peters M; Department of Chemistry, Seattle University, Seattle, WA, USA., France MT; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA., Ravel J; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA., Mitchell CM; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Rakoff-Nahoum S; Division of Infectious Diseases and Division of Gastroenterology, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA. seth.rakoff-nahoum@childrens.harvard.edu.; Department of Microbiology, Harvard Medical School, Boston, MA, USA. seth.rakoff-nahoum@childrens.harvard.edu., Whidbey C; Department of Chemistry, Seattle University, Seattle, WA, USA. whidbeyc@seattleu.edu., Balskus EP; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. balskus@chemistry.harvard.edu.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA. balskus@chemistry.harvard.edu.

Publikováno v: Nature microbiology [Nat Microbiol] 2023 Sep; Vol. 8 (9), pp. 1641-1652. Date of Electronic Publication: 2023 Aug 10.