Inflammation can increase hepcidin in HFE‐hereditary hemochromatosis

Autor: Wenke Moris, Pauline L. M. Verhaegh, Ad A. M. Masclee, Dorine W. Swinkels, Coby M. Laarakkers, Ger H. Koek, Cees Th. B. M. vanDeursen

Publikováno v: Clinical Case Reports, Vol 9, Iss 5, Pp n/a-n/a (2021)

Abstract We present a p.C282Y homozygous patient with high hepcidin levels and normal iron parameters during systemic inflammation. This suggests that in the absence of a proper functioning HFE, resulting in blockage of the BMP/SMAD pathway, the inna

Externí odkaz: https://doaj.org/article/e59ed57f1713497484ab60d64879eba8

Sustained Exposure to High Carbohydrate Availability Does Not Influence Iron-Regulatory Responses in Elite Endurance Athletes

Autor: Alannah K A McKay, Jamie Whitfield, Rachel P. L. van Swelm, Megan L. Ross, Ida A. Heikura, Nicolin Tee, Marijke Welveart, Peter Peeling, Coby M. Laarakkers, Avish P. Sharma, David B. Pyne, Louise M. Burke

Publikováno v: International Journal of Sport Nutrition and Exercise Metabolism, 31, 101-108
International Journal of Sport Nutrition and Exercise Metabolism, 31, 2, pp. 101-108

This study implemented a 2-week high carbohydrate (CHO) diet intended to maximize CHO oxidation rates and examined the iron-regulatory response to a 26-km race walking effort. Twenty international-level, male race walkers were assigned to either a no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04eae1fe624f5f7a2845f2595745738d
https://hdl.handle.net/2066/232269

Provisional standardization of hepcidin assays: creating a traceability chain with a primary reference material, candidate reference method and a commutable secondary reference material

Autor: Annalisa Castagna, Gordana Olbina, Marianne Fillet, Rachel P. L. van Swelm, Marta E Pawlak, Dorine W. Swinkels, Kelly R Pitts, Vincent Delatour, Coby M. Laarakkers, Anton F.J. de Haan, Mark Westerman, Anneke Geurts-Moespot, Laura E. Diepeveen, Thibaud Lefebvre, Fatih F Uğuz, Matthias Herkert, Kim E S A Verberne, Siem M. Klaver, Ioana M. Abbas, Sukhvinder S. Bansal, Outi Itkonen, Cas Weykamp, Gustavo Martos, Domenico Girelli, Naohisa Tomosugi

Publikováno v: Clinical Chemistry and Laboratory Medicine, 57, 6, pp. 864-872
Clinical Chemistry and Laboratory Medicine, 57, 864-872

Background Hepcidin concentrations measured by various methods differ considerably, complicating interpretation. Here, a previously identified plasma-based candidate secondary reference material (csRM) was modified into a serum-based two-leveled sRM.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f512bdb9d0cfe8b6b25c6fbb7219ebf
https://hdl.handle.net/2066/203703

Optimizing hepcidin measurement with a proficiency test framework and standardization improvement

Autor: Thibaud Lefebvre, Andrew E. Armitage, Siem M. Klaver, Laura E. Diepeveen, Outi Itkonen, Naohisa Tomosugi, Dorine W. Swinkels, Marianne Fillet, Markus Rieke, Huiling Han, Ellis T. Aune, Peter Neyer, Daan van de Kerkhof, Aleksandra Krygier, Matthias Herkert, Michael Chen, Sukhvinder S. Bansal, Cas Weykamp, Coby M. Laarakkers

Publikováno v: Clinical Chemistry and Laboratory Medicine, 59(2), 315-323. Walter de Gruyter GmbH
Clinical Chemistry and Laboratory Medicine, 59, 315-323
Clinical Chemistry and Laboratory Medicine, 59, 2, pp. 315-323

Objectives Hepcidin measurement advances insights in pathophysiology, diagnosis, and treatment of iron disorders, but requires analytically sound and standardized measurement procedures (MPs). Recent development of a two-level secondary reference mat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff9b52218613c8b727649c8815d5ceb
https://research.tue.nl/nl/publications/871fb21c-0114-4622-866b-1157dd0aed20

Innovative oral sucrosomial ferric pyrophosphate-based supplementation rescues suckling piglets from iron deficiency anemia similarly to commonly used parenteral therapy with iron dextran

Autor: Rafał Mazgaj, Coby M. Laarakkers, Paweł Lipiński, Robert S. Staron, Rafał R. Starzyński, Aneta Jończy, Dorine W. Swinkels, Mateusz Szudzik, M. Kamyczek, Aleksandra Bednarz, Marek Pieszka, Małgorzata Lenartowicz

Iron deficiency is the most common mammalian nutritional deficiency during the neonatal period. However, among mammalian species neonatal iron deficiency anemia (IDA), the most severe consequence of iron scarcity, occurs regularly in pigs. Although i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::440214d6356075bb8fa359bf11cf2e56
https://ruj.uj.edu.pl/xmlui/handle/item/285772