Synthesis, modeling, and biological evaluation of anti-tubulin indole-substituted furanones.

Autor: Hurysz B; Department of Biology, Hobart and William Smith Colleges, Geneva, NY 14456, USA., Evans BA; Department of Chemistry, Hobart and William Smith Colleges, Geneva, NY 14456, USA., Laryea RN; Department of Molecular Biology and Chemistry, Christopher Newport University, Newport News, VA 23606, USA., Boyer BE; Department of Chemistry, Hobart and William Smith Colleges, Geneva, NY 14456, USA., Coburn TE; Department of Chemistry, Hobart and William Smith Colleges, Geneva, NY 14456, USA., Dexter MS; Department of Chemistry, Hobart and William Smith Colleges, Geneva, NY 14456, USA; Department of Biology, Hobart and William Smith Colleges, Geneva, NY 14456, USA., Edwards MA; Department of Chemistry, Hobart and William Smith Colleges, Geneva, NY 14456, USA., Faulkner GV; Department of Chemistry, Hobart and William Smith Colleges, Geneva, NY 14456, USA., Huss RL; Department of Chemistry, Hobart and William Smith Colleges, Geneva, NY 14456, USA., Lafferty MM; Department of Chemistry, Hobart and William Smith Colleges, Geneva, NY 14456, USA., Manning M; Department of Biology, Hobart and William Smith Colleges, Geneva, NY 14456, USA., McNulty M; Department of Biology, Hobart and William Smith Colleges, Geneva, NY 14456, USA., Melvin SJ; Department of Chemistry, Hobart and William Smith Colleges, Geneva, NY 14456, USA., Mitrow CM; Department of Chemistry, Hobart and William Smith Colleges, Geneva, NY 14456, USA., Patel RR; Department of Chemistry, Hobart and William Smith Colleges, Geneva, NY 14456, USA., Pierce K; Department of Biology, Hobart and William Smith Colleges, Geneva, NY 14456, USA., Russo J; Department of Chemistry, Hobart and William Smith Colleges, Geneva, NY 14456, USA., Seminer AM; Department of Chemistry, Hobart and William Smith Colleges, Geneva, NY 14456, USA., Sockett KA; Department of Chemistry, Hobart and William Smith Colleges, Geneva, NY 14456, USA., Webster NR; Department of Chemistry, Hobart and William Smith Colleges, Geneva, NY 14456, USA., Cole KE; Department of Molecular Biology and Chemistry, Christopher Newport University, Newport News, VA 23606, USA. Electronic address: kathryn.cole@cnu.edu., Mowery P; Department of Biology, Hobart and William Smith Colleges, Geneva, NY 14456, USA. Electronic address: mowery@hws.edu., Pelkey ET; Department of Chemistry, Hobart and William Smith Colleges, Geneva, NY 14456, USA. Electronic address: pelkey@hws.edu.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 Jun 15; Vol. 90, pp. 129347. Date of Electronic Publication: 2023 May 24.