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The enhancement of activity rescues the establishment of Mecp2 null neuronal phenotypes

Autor: Massimiliano Pagani, Davide Pozzi, Linda Scaramuzza, M. De Simone, D. Genni, Filippo Mirabella, Fabio Benfenati, Fabrizia Cesca, Nicoletta Landsberger, G. De Rocco, C. G. Clementina, Martina Chiacchiaretta, Paola Conforti, Francesco Bedogni

Publikováno v: EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 13, Iss 4, Pp n/a-n/a (2021)

MECP2 mutations cause Rett syndrome (RTT), a severe and progressive neurodevelopmental disorder mainly affecting females. Although RTT patients exhibit delayed onset of symptoms, several evidences demonstrate that MeCP2 deficiency alters early develo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b09a6f93f9505c33ebd8d3fe0f3407bc
http://europepmc.org/articles/PMC8033520

Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.

Autor: Bedogni F; San Raffaele Rett Research Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy., Cobolli Gigli C; San Raffaele Rett Research Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.; Laboratory of Genetic and Epigenetic Control of Gene Expression, Division of Biomedical Research, Department of Theoretical and Applied Sciences, University of Insubria, Busto Arsizio, 21052 Varese, Italy., Pozzi D; Laboratory of Pharmacology and Brain Pathology, Humanitas Clinical and Research Center, Rozzano, 20089 Milan, Italy., Rossi RL; Istituto Nazionale di Genetica Molecolare 'Romeo ed Enrica Invernizzi', 20122 Milan, Italy., Scaramuzza L; San Raffaele Rett Research Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy., Rossetti G; Istituto Nazionale di Genetica Molecolare 'Romeo ed Enrica Invernizzi', 20122 Milan, Italy., Pagani M; Istituto Nazionale di Genetica Molecolare 'Romeo ed Enrica Invernizzi', 20122 Milan, Italy., Kilstrup-Nielsen C; Laboratory of Genetic and Epigenetic Control of Gene Expression, Division of Biomedical Research, Department of Theoretical and Applied Sciences, University of Insubria, Busto Arsizio, 21052 Varese, Italy., Matteoli M; Laboratory of Pharmacology and Brain Pathology, Humanitas Clinical and Research Center, Rozzano, 20089 Milan, Italy.; Dip di Biotecnologie Mediche e Medicina Traslazionale, Università di Milano, Milan, Italy., Landsberger N; San Raffaele Rett Research Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.; Laboratory of Genetic and Epigenetic Control of Gene Expression, Division of Biomedical Research, Department of Theoretical and Applied Sciences, University of Insubria, Busto Arsizio, 21052 Varese, Italy.

Publikováno v: Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2016 Jun; Vol. 26 (6), pp. 2517-2529. Date of Electronic Publication: 2015 May 15.

Methyl-CpG binding protein 2 (MeCP2) localizes at the centrosome and is required for proper mitotic spindle organization.

Autor: Bergo A; From the Department of Theoretical and Applied Sciences, Section of Biomedical Research, University of Insubria, 21052 Busto Arsizio, Italy., Strollo M; From the Department of Theoretical and Applied Sciences, Section of Biomedical Research, University of Insubria, 21052 Busto Arsizio, Italy., Gai M; the Molecular Biotechnology Center, Department of Molecular Biotechnologies and Health Sciences, University of Turin, 10126 Turin, Italy., Barbiero I; From the Department of Theoretical and Applied Sciences, Section of Biomedical Research, University of Insubria, 21052 Busto Arsizio, Italy., Stefanelli G; From the Department of Theoretical and Applied Sciences, Section of Biomedical Research, University of Insubria, 21052 Busto Arsizio, Italy., Sertic S; the Department of Life Sciences, University of Milan, 20133 Milan, Italy, and., Cobolli Gigli C; the San Raffaele Rett Research Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy., Di Cunto F; the Molecular Biotechnology Center, Department of Molecular Biotechnologies and Health Sciences, University of Turin, 10126 Turin, Italy., Kilstrup-Nielsen C; From the Department of Theoretical and Applied Sciences, Section of Biomedical Research, University of Insubria, 21052 Busto Arsizio, Italy., Landsberger N; From the Department of Theoretical and Applied Sciences, Section of Biomedical Research, University of Insubria, 21052 Busto Arsizio, Italy, the San Raffaele Rett Research Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy landsben@uninsubria.it.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2015 Feb 06; Vol. 290 (6), pp. 3223-37. Date of Electronic Publication: 2014 Dec 19.