Successful Proof-of-Concept for Topical Delivery of Novel Peptide ALM201 with Potential Usefulness for Treating Neovascular Eye Disorders

Autor: Obasanmi, Gideon, Nesbit, M. Andrew, Cobice, Diego, Mackay, Logan, McGimpsey, Stuart, Wappett, Mark, Cranston, Aaron N., Moore, Tara C.B.

Publikováno v: In Ophthalmology Science June 2022 2(2)

Effective In Vivo Topical Delivery of siRNA and Gene Silencing in Intact Corneal Epithelium Using a Modified Cell-Penetrating Peptide

Autor: Schiroli, Davide, Gómara, María J., Maurizi, Eleonora, Atkinson, Sarah D., Mairs, Laura, Christie, Kathleen A., Cobice, Diego F., McCrudden, Cian M., Nesbit, M. Andrew, Haro, Isabel, Moore, Tara

Publikováno v: In Molecular Therapy - Nucleic Acids 6 September 2019 17:891-906

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Contribution of local regeneration of glucocorticoids to tissue steroid pools

Autor: Khan, Shazia, Livingstone, Dawn E. W, Zielinska, Agnieszka, Doig, Craig L, Cobice, Diego F, Esteves, Cristina L, Man, Janet Tak Yun, Homer, Natalie Z.M., Seckl, Jonathan R, Mackay, C.Logan, Webster, Scott P, Lavery, Gareth G, Chapman, Karen E, Walker, Brian R, Andrew, Ruth

Publikováno v: Khan, S, Livingstone, D E W, Zielinska, A, Doig, C L, Cobice, D F, Esteves, C L, Man, J T Y, Homer, N Z M, Seckl, J R, Mackay, C L, Webster, S P, Lavery, G G, Chapman, K E, Walker, B R & Andrew, R 2023, ' Contribution of local regeneration of glucocorticoids to tissue steroid pools ', Journal of Endocrinology . https://doi.org/10.1530/JOE-23-0034

11β-Hydroxysteroid dehydrogenase 1 (11βHSD1) is a drug target to attenuate adverse effects of chronic glucocorticoid excess. It catalyses intracellular regeneration of active glucocorticoids in tissues including brain, liver and adipose tissue (cou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::4b54a9913dae93121ea0c40b6dbf4c35
https://www.pure.ed.ac.uk/ws/files/361561412/Khan_et_al_merged.pdf

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