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An ultralong-acting tenofovir ProTide nanoformulation achieves monthslong HBV suppression.

Autor: Das S; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA.; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA., Wang W; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA., Ganesan M; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68105, USA.; Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE 68105, USA., Fonseca-Lanza F; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA., Cobb DA; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA., Bybee G; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68105, USA.; Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE 68105, USA., Sun Y; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA., Guo L; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA., Hanson B; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA., Cohen SM; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA., Gendelman HE; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA.; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68105, USA., Osna NA; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68105, USA.; Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE 68105, USA., Edagwa BJ; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA., Poluektova LY; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Publikováno v: Science advances [Sci Adv] 2022 Dec 23; Vol. 8 (51), pp. eade9582. Date of Electronic Publication: 2022 Dec 23.

Transformation of tenofovir into stable ProTide nanocrystals with long-acting pharmacokinetic profiles.

Autor: Cobb DA; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA., Smith N; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA., Deodhar S; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA., Bade AN; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA., Gautam N; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA., Shetty BLD; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA., McMillan J; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA., Alnouti Y; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA., Cohen SM; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA., Gendelman HE; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA., Edagwa B; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA. benson.edagwa@unmc.edu.

Publikováno v: Nature communications [Nat Commun] 2021 Sep 16; Vol. 12 (1), pp. 5458. Date of Electronic Publication: 2021 Sep 16.

Long-acting approaches for delivery of antiretroviral drugs for prevention and treatment of HIV: a review of recent research.

Autor: Cobb DA; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center , Omaha, NE, USA., Smith NA; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center , Omaha, NE, USA., Edagwa BJ; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center , Omaha, NE, USA., McMillan JM; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center , Omaha, NE, USA.; Department of Environmental, Agricultural and Occupational Health, University of Nebraska Medical Center , Omaha, NE, USA.

Publikováno v: Expert opinion on drug delivery [Expert Opin Drug Deliv] 2020 Sep; Vol. 17 (9), pp. 1227-1238. Date of Electronic Publication: 2020 Jul 06.