Drug Repurposing: Deferasirox Inhibits the Anti-Apoptotic Activity of Mcl-1

Autor: Bourafai-Aziez A, Benabderrahmane M, Paysant H, Weiswald LB, Poulain L, Carlier L, Ravault D, Jouanne M, Coadou G, Oulyadi H, Voisin-Chiret AS, Sopková-de Oliveira Santos J, Sebban M

Publikováno v: Drug Design, Development and Therapy, Vol Volume 15, Pp 5035-5059 (2021)

Asma Bourafai-Aziez,1 Mohammed Benabderrahmane,2 Hippolyte Paysant,3,4 Louis-Bastien Weiswald,3,4 Laurent Poulain,3,4 Ludovic Carlier,5 Delphine Ravault,5 Marie Jouanne,2 Gaël Coadou,1 Hassan Oulyadi,1 Anne-Sophie Voisin-Chiret,2 Jana Sopková-de Ol

Externí odkaz: https://doaj.org/article/1e0169606ae444dbb4a8160f229da0f6

Supercritical fluid chromatography for separation of chiral planar metallocenes.

Autor: Bonin L; Univ. Lille, Inserm, Institut Pasteur de Lille, U1167 - Risk factors and molecular determinants of aging-related diseases, F-59000 Lille, France; JUNIA, Health & Environment, Laboratory of Sustainable Chemistry and Health, F-59000 Lille, France; Normandie Université, INSA de Rouen, CNRS, Laboratoire COBRA (UMR 6014 & FR 3038), F-76000 Rouen, France., Morvan A; Univ. Lille, Inserm, Institut Pasteur de Lille, U1167 - Risk factors and molecular determinants of aging-related diseases, F-59000 Lille, France., Coadou G; Normandie Université, INSA de Rouen, CNRS, Laboratoire COBRA (UMR 6014 & FR 3038), F-76000 Rouen, France., Furman C; Univ. Lille, Inserm, Institut Pasteur de Lille, U1167 - Risk factors and molecular determinants of aging-related diseases, F-59000 Lille, France., Boulanger E; Univ. Lille, Inserm, Institut Pasteur de Lille, U1167 - Risk factors and molecular determinants of aging-related diseases, F-59000 Lille, France., Ghinet A; Univ. Lille, Inserm, Institut Pasteur de Lille, U1167 - Risk factors and molecular determinants of aging-related diseases, F-59000 Lille, France; JUNIA, Health & Environment, Laboratory of Sustainable Chemistry and Health, F-59000 Lille, France; Alexandru Ioan Cuza' University of Iasi, Faculty of Chemistry, Bd. Carol I nr. 11, 700506 Iasi, Romania., Lipka E; Univ. Lille, Inserm, Institut Pasteur de Lille, U1167 - Risk factors and molecular determinants of aging-related diseases, F-59000 Lille, France. Electronic address: emmanuelle.lipka@univ-lille.fr.

Publikováno v: Journal of chromatography. A [J Chromatogr A] 2022 Jul 05; Vol. 1674, pp. 463115. Date of Electronic Publication: 2022 May 13.

Fluorocyclopropane-Containing Proline Analogue: Synthesis and Conformation of an Item in the Peptide Chemist's Toolbox.

Autor: Pons A; Normandie Université, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France., Decaens J; Normandie Université, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France., Najjar R; Normandie Université, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France., Otog N; Department of Applied Chemistry and Life Science, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku, Toyohashi, Aichi 441-8580, Japan., Arribat M; Normandie Université, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France., Jolly S; Analytical Sciences-Discovery Sciences, Janssen Research & Development, a Division of Janssen-Cilag, Campus de Maigremont, CS10615, F-27106 Val de Reuil Cedex, France., Couve-Bonnaire S; Normandie Université, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France., Sebban M; Normandie Université, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France., Coadou G; Normandie Université, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France., Oulyadi H; Normandie Université, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France., Speybrouck D; Analytical Sciences-Discovery Sciences, Janssen Research & Development, a Division of Janssen-Cilag, Campus de Maigremont, CS10615, F-27106 Val de Reuil Cedex, France., Iwasa S; Department of Applied Chemistry and Life Science, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku, Toyohashi, Aichi 441-8580, Japan., Charette AB; Centre in Green Chemistry and Catalysis, Faculty of Arts and Sciences, Department of Chemistry, Université de Montréal, P.O. Box 6128, Station Downtown, Montréal, Québec H3C3J7, Canada., Poisson T; Normandie Université, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France.; Institut Universitaire de France, 1 rue Descartes, 75231 Paris, France., Jubault P; Normandie Université, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France.

Publikováno v: ACS omega [ACS Omega] 2022 Feb 04; Vol. 7 (6), pp. 4868-4878. Date of Electronic Publication: 2022 Feb 04 (Print Publication: 2022).

Peptides corresponding to the N- and C-terminal parts of PEBP are well-structured in solution: new insights into their possible interaction with partners in vivo.

Autor: Vallee, B.S., Coadou, G., Labbe, H., Sy, D., Vovelle, F., Schoentgen, F.

Publikováno v: Journal of Peptide Research. Feb2003, Vol. 61 Issue 2, p47. 11p.

Rational design of carbamate-based dual binding site and central AChE inhibitors by a "biooxidisable" prodrug approach: Synthesis, in vitro evaluation and docking studies.

Autor: Ţînţaş ML; Normandie Univ, UNIROUEN, INSA Rouen, CNRS, COBRA, 76000, Rouen, France., Gembus V; VFP Therapies, 15 rue François Couperin, 76000, Rouen, France. Electronic address: vgembus@vfp-therapies.com., Alix F; VFP Therapies, 15 rue François Couperin, 76000, Rouen, France., Barré A; VFP Therapies, 15 rue François Couperin, 76000, Rouen, France; Normandie Univ, UNIROUEN, INSA Rouen, CNRS, COBRA, 76000, Rouen, France., Coadou G; Normandie Univ, UNIROUEN, INSA Rouen, CNRS, COBRA, 76000, Rouen, France., Truong L; Normandie Univ, UNIROUEN, INSA Rouen, CNRS, COBRA, 76000, Rouen, France., Sebban M; Normandie Univ, UNIROUEN, INSA Rouen, CNRS, COBRA, 76000, Rouen, France., Papamicaël C; Normandie Univ, UNIROUEN, INSA Rouen, CNRS, COBRA, 76000, Rouen, France., Oulyadi H; Normandie Univ, UNIROUEN, INSA Rouen, CNRS, COBRA, 76000, Rouen, France., Levacher V; Normandie Univ, UNIROUEN, INSA Rouen, CNRS, COBRA, 76000, Rouen, France. Electronic address: vincent.levacher@insa-rouen.fr.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2018 Jul 15; Vol. 155, pp. 171-182. Date of Electronic Publication: 2018 Jun 01.