Zobrazeno 1 - 10
of 4 548
pro vyhledávání: '"CoMFA"'
Akademický článek
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Akademický článek
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Autor:
Soukaina Bouamrane, Ayoub Khaldan, Marwa Alaqarbeh, Abdelouahid Sbai, Mohammed Aziz Ajana, Tahar Lakhlifi, Mohammed Bouachrine, Hamid Maghat
Publikováno v:
Chemical Physics Impact, Vol 8, Iss , Pp 100502- (2024)
Fungal infections are a growing public health problem worldwide. Despite the availability of several medicines, their efficacy is still constrained by fungal resistance. This research conducted the 2D/3D-QSAR analysis on twenty-nine triazole molecule
Externí odkaz:
https://doaj.org/article/ed52f1aba3dd48468596591a87199319
Autor:
Yifan Wang, Shunjiang Jia, Fan Wang, Ruizhe Jiang, Xiaodan Yin, Shuo Wang, Ruyi Jin, Hui Guo, Yuping Tang, Yuwei Wang
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7434 (2024)
Isocitrate dehydrogenase 1 (IDH1) is a necessary enzyme for cellular respiration in the tricarboxylic acid cycle. Mutant isocitrate dehydrogenase 1 (mIDH1) has been detected overexpressed in a variety of cancers. mIDH1 inhibitor ivosidenib (AG-120) w
Externí odkaz:
https://doaj.org/article/cfa6ecbd77384d358ca70cead9ed5a48
Autor:
Lorca Marcos, Faúndez Mario, Pessoa-Mahana David C., Recabarren-Gajardo Gonzalo, Diethelm-Varela Benjamin, Millán Daniela, Celik Ismail, Mellado Marco, Araque Ileana, Mella Jaime, Romero-Parra Javier
Publikováno v:
Journal of the Serbian Chemical Society, Vol 88, Iss 1, Pp 25-39 (2023)
Human leukotriene A4 hydrolase enzyme (LTA4H) catalyses the biotransformation of the inactive precursor leukotriene A4 (LTA4) to the bioactive Leukotriene B4 (LTB4), which causes many inflammatory responses in the human body. Therefore, the selective
Externí odkaz:
https://doaj.org/article/6e6af4135346410895102f6ad764fc83
Autor:
Khaoula Mkhayar, Ossama Daoui, Rachid Haloui, Kaouakeb Elkhattabi, Abdelmoula Elabbouchi, Samir Chtita, Abdelouahid Samadi, Souad Elkhattabi
Publikováno v:
Molecules, Vol 29, Iss 2, p 426 (2024)
In this study, using the Comparative Molecular Field Analysis (CoMFA) approach, the structure-activity relationship of 33 small quinoline-based compounds with biological anti-gastric cancer activity in vitro was analyzed in 3D space. Once the 3D geom
Externí odkaz:
https://doaj.org/article/fbaec9c3b7d44b16ae46aa631082407a
Autor:
Emmanuel Israel Edache, Adamu Uzairu, Paul Andrew Mamza, Gideon Adamu Shallangwa, Fatma Hilal Yagin, Nagwan Abdel Samee, Noha F. Mahmoud
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
The development of novel medicines to treat autoimmune diseases and SARS-CoV-2 main protease (Mpro), a virus that can cause both acute and chronic illnesses, is an ongoing necessity for the global community. The primary objective of this research is
Externí odkaz:
https://doaj.org/article/f3514e3f383f41f5982a5a9da53f7e7f
Autor:
Juan Andrades-Lagos, Javier Campanini-Salinas, Gianfranco Sabadini, Victor Andrade, Jaime Mella, David Vásquez-Velásquez
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1621 (2023)
According to the WHO, antimicrobial resistance is among the top 10 threats to global health. Due to increased resistance rates, an increase in the mortality and morbidity of patients has been observed, with projections of more than 10 million deaths
Externí odkaz:
https://doaj.org/article/75359a3bdc5a46348b44f4f6f7d7e1ca
Akademický článek
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Publikováno v:
Climate Risk Management, Vol 40, Iss , Pp 100508- (2023)
Heat stress can have negative effects on human wellbeing with morbidity and mortality as harmful consequences, especially in vulnerable groups, e.g. children, elderly and chronically ill. Children is for example at higher risk of dehydration and heat
Externí odkaz:
https://doaj.org/article/2d8aa6bf941c4924880bbe04715482b0