Zobrazeno 1 - 10 of 63 pro vyhledávání: '"Co-crystallisation"'
1
Akademický článek
Se-MAG Is a Convenient Additive for Experimental Phasing and Structure Determination of Membrane Proteins Crystallised by the Lipid Cubic Phase (In Meso) Method
Autor: Coilín Boland, Chia-Ying Huang, Shiva Shanker Kaki, Meitian Wang, Vincent Olieric, Martin Caffrey
Publikováno v: Crystals, Vol 13, Iss 9, p 1402 (2023)
Both intensity and phase information are needed for structure determination by macromolecular X-ray crystallography. The diffraction experiment provides intensities. Phases must be accessed indirectly by molecular replacement, or by experimental phas
Externí odkaz: https://doaj.org/article/5c89fea58bcb460cbe8b99cd4d1a2b11
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2
Akademický článek
Design of new disubstituted imidazo[1,2-b]pyridazine derivatives as selective Haspin inhibitors. Synthesis, binding mode and anticancer biological evaluation
Autor: Jonathan Elie, Omid Feizbakhsh, Nathalie Desban, Béatrice Josselin, Blandine Baratte, Amandine Bescond, Julien Duez, Xavier Fant, Stéphane Bach, Dominique Marie, Matthieu Place, Sami Ben Salah, Agnes Chartier, Sabine Berteina-Raboin, Apirat Chaikuad, Stefan Knapp, Fabrice Carles, Pascal Bonnet, Frédéric Buron, Sylvain Routier, Sandrine Ruchaud
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1840-1853 (2020)
Haspin is a mitotic protein kinase required for proper cell division by modulating Aurora B kinase localisation and activity as well as histone phosphorylation. Here a series of imidazopyridazines based on the CHR-6494 and Structure Activity Relation
Externí odkaz: https://doaj.org/article/090287ce3ba04ea5ab8ef21466f6dc6b
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3
Akademický článek
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4
Akademický článek
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5
Akademický článek
Synthesis of caffeine/maleic acid co-crystal by ultrasound assisted slurry co-crystallization
Autor: Apshingekar, Prafulla P., Aher, Suyog, Kelly, Adrian L., Brown, Elaine, Paradkar, Anant R
Yes
A green approach has been used for co-crystallization of non-congruent co-crystal pair of caffeine – maleic acid using water. Ultrasound is known to affect crystallization hence the effect of high power ultrasound on the ternary phase diag
Externí odkaz: http://hdl.handle.net/10454/8961
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6
Crystal growth and design of multicomponent pharmaceuticals
Autor: O’Malley, Ciaran
Cocrystallisation and salt formation is a widely studied method of optimising the action of Active Pharmaceutical Ingredients (APIs) without chemical modification of the parent compound. Careful selection of suitable coformers can lead to enhancement
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1513::65e8cde83ab0f21c4da6124198653834
http://hdl.handle.net/10379/17327
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7
Akademický článek
Super Potent Bispecific Llama VHH Antibodies Neutralize HIV via a Combination of gp41 and gp120 Epitopes
Autor: Nika M. Strokappe, Miriam Hock, Lucy Rutten, Laura E. Mccoy, Jaap W. Back, Christophe Caillat, Matthias Haffke, Robin A. Weiss, Winfried Weissenhorn, Theo Verrips
Publikováno v: Antibodies, Vol 8, Iss 2, p 38 (2019)
Broad and potent neutralizing llama single domain antibodies (VHH) against HIV-1 targeting the CD4 binding site (CD4bs) have previously been isolated upon llama immunization. Here we describe the epitopes of three additional VHH groups selected from
Externí odkaz: https://doaj.org/article/2e8d01ac0ce44807b40322c7b3eaad84
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8
Dissertation/ Thesis
Crystal Engineering of Pharmaceuticals: Modulating Physicochemical Properties of Active Ingredients by the Formation of Cocrystals
Autor: Jhariya, Aditya N.
Pharmaceuticals with suitable therapeutic properties often found to encounter challenges with dosage form development due to their poor physicochemical properties. Aim of thesis is to evaluate potential of crystal engineering directed cocrystallisati
Externí odkaz: http://hdl.handle.net/10454/19698
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9
Akademický článek
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10
Design of new disubstituted imidazo[1,2- b ]pyridazine derivatives as selective Haspin inhibitors. Synthesis, binding mode and anticancer biological evaluation
Autor: Matthieu Place, Omid Feizbakhsh, Amandine Bescond, Apirat Chaikuad, Agnes Chartier, Sandrine Ruchaud, Frédéric Buron, Sylvain Routier, Julien Duez, Stefan Knapp, Dominique Marie, Blandine Baratte, Nathalie Desban, Stéphane Bach, Fabrice Carles, Jonathan Elie, Xavier Fant, Sami Ben Salah, Béatrice Josselin, Sabine Berteina-Raboin, Pascal Bonnet
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020, 35 (1), pp.1840-1853. ⟨10.1080/14756366.2020.1825408⟩
Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2020, 35 (1), pp.1840-1853. ⟨10.1080/14756366.2020.1825408⟩
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1840-1853 (2020)
article-version (VoR) Version of Record
Haspin is a mitotic protein kinase required for proper cell division by modulating Aurora B kinase localisation and activity as well as histone phosphorylation. Here a series of imidazopyridazines based on the CHR-6494 and Structure Activity Relation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c123cd3addc29babf164e9067364ee8
https://hal.science/hal-03004407
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