Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Co-clinical trials"'
Autor:
Donna M. Peehl, Cristian T. Badea, Thomas L. Chenevert, Heike E. Daldrup-Link, Li Ding, Lacey E. Dobrolecki, A. McGarry Houghton, Paul E. Kinahan, John Kurhanewicz, Michael T. Lewis, Shunqiang Li, Gary D. Luker, Cynthia X. Ma, H. Charles Manning, Yvonne M. Mowery, Peter J. O'Dwyer, Robia G. Pautler, Mark A. Rosen, Raheleh Roudi, Brian D. Ross, Kooresh I. Shoghi, Renuka Sriram, Moshe Talpaz, Richard L. Wahl, Rong Zhou
Publikováno v:
Tomography, Vol 9, Iss 2, Pp 657-680 (2023)
The availability of high-fidelity animal models for oncology research has grown enormously in recent years, enabling preclinical studies relevant to prevention, diagnosis, and treatment of cancer to be undertaken. This has led to increased opportunit
Externí odkaz:
https://doaj.org/article/315dd791b13b4c40966ef7abc8d61d4c
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Lung cancer is one of the most prevalent, fatal, and highly heterogeneous diseases that, seriously threaten human health. Lung cancer is primarily caused by the aberrant expression of multiple genes in the cells. Lung cancer treatment options include
Externí odkaz:
https://doaj.org/article/8228ebe413914e80ae3d308f1b1e5ecc
Autor:
Go J. Yoshida
Publikováno v:
Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-16 (2020)
Abstract Patient-derived tumor xenografts (PDXs), in which tumor fragments surgically dissected from cancer patients are directly transplanted into immunodeficient mice, have emerged as a useful model for translational research aimed at facilitating
Externí odkaz:
https://doaj.org/article/8013db859f2c4d9eb61da5198872f792
Autor:
Majd A. Al-Hamaly, Logan T. Turner, Angelica Rivera-Martinez, Analiz Rodriguez, Jessica S. Blackburn
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2288 (2023)
The increasing number of available anti-cancer drugs presents a challenge for oncologists, who must choose the most effective treatment for the patient. Precision cancer medicine relies on matching a drug with a tumor’s molecular profile to optimiz
Externí odkaz:
https://doaj.org/article/f2ac221545b54bb8a0658d7d9e2d81f0
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Novel oncology drugs often fail to progress from preclinical experiments to FDA approval. Therefore, determining which preclinical or clinical factors associate with drug activity could accelerate development of effective therapies. We investigated w
Externí odkaz:
https://doaj.org/article/8767353a80de40abb2ca672e08a8c8eb
Autor:
Brinda Balasubramanian, Simran Venkatraman, Kyaw Zwar Myint, Tavan Janvilisri, Kanokpan Wongprasert, Supeecha Kumkate, David O. Bates, Rutaiwan Tohtong
Publikováno v:
Pharmaceuticals, Vol 14, Iss 1, p 51 (2021)
Cholangiocarcinoma (CCA), a group of malignancies that originate from the biliary tract, is associated with a high mortality rate and a concerning increase in worldwide incidence. In Thailand, where the incidence of CCA is the highest, the socioecono
Externí odkaz:
https://doaj.org/article/d19aab24e78d4953b081c1425bcadab0
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 10, Pp 1185-1200 (2015)
Pancreatic ductal adenocarcinoma is the most common form of pancreatic tumour, with a very limited survival rate and currently no available disease-modifying treatments. Despite recent advances in the production of genetically engineered mouse models
Externí odkaz:
https://doaj.org/article/5e6bdc5d49834fd9899584727434905b
Autor:
Yoshida, Go J.
Publikováno v:
Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-16 (2020)
Journal of Hematology & Oncology
Journal of Hematology & Oncology
Patient-derived tumor xenografts (PDXs), in which tumor fragments surgically dissected from cancer patients are directly transplanted into immunodeficient mice, have emerged as a useful model for translational research aimed at facilitating precision
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e20596dd11f91dcd99ff3837e9a45a
https://doaj.org/article/8013db859f2c4d9eb61da5198872f792
https://doaj.org/article/8013db859f2c4d9eb61da5198872f792
Autor:
Lisa M. Saksida, Timothy J. Bussey, Elizabeth Finger, Tyler D. Dexter, Julie R. Dumont, Daniel Palmer, Marco A. M. Prado
Publikováno v:
Brain and Mind Institute Researchers' Publications
Translating results from pre-clinical animal studies to successful human clinical trials in neurodegenerative and neuropsychiatric disease presents a significant challenge. While this issue is clearly multifaceted, the lack of reproducibility and poo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92848359201d6c7ab9e90cb7d5f6e9fd
https://ir.lib.uwo.ca/brainpub/696
https://ir.lib.uwo.ca/brainpub/696
Publikováno v:
Frontiers in Oncology
Frontiers in Oncology, Vol 10 (2020)
Frontiers in Oncology, Vol 10 (2020)
Novel oncology drugs often fail to progress from preclinical experiments to FDA approval. Therefore, determining which preclinical or clinical factors associate with drug activity could accelerate development of effective therapies. We investigated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a87f16f579cb7266431578811b040c
https://doi.org/10.3389/fonc.2020.587377
https://doi.org/10.3389/fonc.2020.587377