Výsledky vyhledávání - "Cnubben, N.H.P."

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The minipig as an alternative non-rodent model for immunogenicity testing using the TNFα blockers adalimumab and infliximab

Autor: Mierlo, G.J.D. van, Cnubben, N.H.P., Wouters, D., Wolbink, G.J., Hart, M.H.L., Rispens, T., Ganderup, N.C., Kuper, C.F., Aarden, L., Penninks, A.H.

Publikováno v: Journal of Immunotoxicology, 1, 11, 62-71

Immunogenicity is a major issue of concern for monoclonal antibodies used in human diseases and is by default mainly determined in non-human primates (NHP), as target molecules are considered most similar in NHP compared to human. In this manuscript

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The Göttingen minipig® as an alternative non-rodent species for immunogenicity testing: A demonstrator study using the IL-1 receptor antagonist anakinra

Autor: Mierlo, G.J.D. van, Cnubben, N.H.P., Kuper, C.F., Wolthoorn, J., Meeteren-Kreikamp, A.P. van, Nagtegaal, M.M., Doornbos, R., Ganderup, N.-C., Penninks, A.H.

Publikováno v: Journal of Immunotoxicology, 1, 10, 96-105

The use of recombinant human proteins for the treatment of several diseases has increased considerably during the last decades. A major safety and efficacy issue of biopharmaceuticals is their potential immunogenicity. To prevent immunogenicity, biot

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Comparative MO-QSAR studies in various species including man

Autor: Tyrakowska, B., Cnubben, N.H.P., Soffers, A.E.M.F., Wobbes, Th., Rietjens, I.M.C.M.

Publikováno v: Chemistry & Biology, 100, pp. 187-201
Chemistry & Biology, 100, 187-201
Chemistry & Biology, 100, 2, pp. 187-201

Contains fulltext : 23551___.PDF (Publisher’s version ) (Open Access)

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https://hdl.handle.net/2066/23551

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Integration of efficacy, pharmacokinetic and safety assessment of interleukin-1 receptor antagonist in a preclinical model of arthritis

Autor: Zuurmond, A.M., Koudijs, A., El, B. van, Doornbos, R.P., Manen-Vernooij, B.C.T. van, Bastiaans, J.H.M.W., Penninks, A.H., Bilsen, J.H.M. van, Cnubben, N.H.P., Groot, J. de

Publikováno v: Regulatory Toxicology and Pharmacology, 3, 59, 461-470

Pharmacokinetic properties and safety profile of a drug are likely influenced by the disease state of a patient. In this study, we investigated the influence of arthritic processes on pharmacokinetics and immunotoxicity of interleukin-1 receptor anta

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Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food-borne toxic compounds and bioactive ingredients

Autor: Brand, W., Schutte, M.E., Williamson, G., Zanden, J.J. van, Cnubben, N.H.P., Groten, J.P., Bladeren, P.J. van, Rietjens, I.M.C.M.

Publikováno v: Biomedicine and Pharmacotherapy, 9, 60, 508-519

The transcellular transport of ingested food ingredients across the intestinal epithelial barrier is an important factor determining bioavailability upon oral intake. This transcellular transport of many chemicals, food ingredients, drugs or toxic co

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Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2

Autor: Zanden, J.J. van, Wortelboer, H.M., Bijlsma, S., Punt, A., Usta, M., Bladeren, P.J.V., Rietjens, I.M.C.M., Cnubben, N.H.P.

In the present study, the effects of a large series of flavonoids on multidrug resistance proteins (MRPs) were studied in MRP1 and MRP2 transfected MDCKII cells. The results were used to define the structural requirements of flavonoids necessary for

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Comparative in vitro-in vivo percutaneous penetration of the fungicide ortho-phenylphenol

Autor: Cnubben, N.H.P., Elliott, G.R., Hakkert, B.C., Meuling, W.J.A., Sandt, J.J.M. van de

Publikováno v: Regulatory Toxicology and Pharmacology, 2 I, 35, 198-208

The validity of in vitro and in vivo methods for the prediction of percutaneous penetration in humans was assessed using the fungicide ortho-phenylphenol (OPP) (log Po/w 3.28, MW 170.8, solubility in water 0.7 g/L). In vivo studies were performed in

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