Zobrazeno 1 - 10
of 590
pro vyhledávání: '"Cmielewski, P."'
Autor:
Nicole Reyne, Ronan Smith, Patricia Cmielewski, Nina Eikelis, Mark Lawrence, Jennie Louise, Piraveen Pirakalathanan, David Parsons, Martin Donnelley
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Two cystic fibrosis (CF) rat models, one carrying the common Phe508del mutation and the other a nonsense cystic fibrosis transmembrane conductance regulator (CFTR) mutation (knockout) were previously characterised. Although relevant CFTR mRN
Externí odkaz:
https://doaj.org/article/f30e6698146645fa9909c5f556e1586c
Autor:
Nicole Reyne, Patricia Cmielewski, Alexandra McCarron, Ronan Smith, Elena Schneider-Futschik, Nina Eikelis, Piraveen Pirakalathanan, David Parsons, Martin Donnelley
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/725af926fa9c429f9377c586aaa5b7a7
Autor:
Jiraporn Ousingsawat, Raquel Centeio, Nicole Reyne, Alexandra McCarron, Patricia Cmielewski, Rainer Schreiber, Gabriella diStefano, Dorothee Römermann, Ursula Seidler, Martin Donnelley, Karl Kunzelmann
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The Ca2+ activated Cl− channel TMEM16A (anoctamin 1; ANO1) is expressed in secretory epithelial cells of airways and intestine. Previous studies provided evidence for a role of ANO1 in mucus secretion. In the present study we investigated
Externí odkaz:
https://doaj.org/article/06c1135f56334127a708313a72426579
Autor:
Nicole Reyne, Patricia Cmielewski, Alexandra McCarron, Ronan Smith, Elena Schneider-Futschik, Nina Eikelis, Piraveen Pirakalathanan, David Parsons, Martin Donnelley
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction:Phe508del is the most common cystic fibrosis transmembrane conductance regulator (CFTR) gene variant that results in the recessive genetic disorder cystic fibrosis (CF). The recent development of highly effective CFTR modulator therapies
Externí odkaz:
https://doaj.org/article/d6e52064a46e407fbcacadcbcf9524f1
Autor:
McCarron A; Adelaide Medical School, The University of Adelaide, Adelaide, SA, Australia. alexandra.mccarron@adelaide.edu.au.; Robinson Research Institute, The University of Adelaide, Adelaide, SA, Australia. alexandra.mccarron@adelaide.edu.au.; Department of Respiratory and Sleep Medicine, Women's and Children's Hospital, North Adelaide, SA, Australia. alexandra.mccarron@adelaide.edu.au., Ling KM; Wal-Yan Respiratory Research Centre, Telethon Kids Institute, Nedlands, WA, Australia.; School of Population Health, Curtin University, Bentley, WA, Australia., Montgomery ST; Wal-Yan Respiratory Research Centre, Telethon Kids Institute, Nedlands, WA, Australia.; School of Population Health, Curtin University, Bentley, WA, Australia., Martinovich KM; Wal-Yan Respiratory Research Centre, Telethon Kids Institute, Nedlands, WA, Australia.; Centre for Child Health Research, University of Western Australia, Crawley, WA, Australia., Cmielewski P; Adelaide Medical School, The University of Adelaide, Adelaide, SA, Australia.; Robinson Research Institute, The University of Adelaide, Adelaide, SA, Australia.; Department of Respiratory and Sleep Medicine, Women's and Children's Hospital, North Adelaide, SA, Australia., Rout-Pitt N; Adelaide Medical School, The University of Adelaide, Adelaide, SA, Australia.; Robinson Research Institute, The University of Adelaide, Adelaide, SA, Australia.; Department of Respiratory and Sleep Medicine, Women's and Children's Hospital, North Adelaide, SA, Australia., Kicic A; Wal-Yan Respiratory Research Centre, Telethon Kids Institute, Nedlands, WA, Australia.; School of Population Health, Curtin University, Bentley, WA, Australia.; Department of Respiratory and Sleep, Perth Children's Hospital, Nedlands, WA, Australia.; Centre for Cell Therapy and Regenerative Medicine, School of Medicine and Pharmacology, The University of Western Australia and Harry Perkins Institute of Medical Research, Nedlands, WA, Australia., Parsons D; Adelaide Medical School, The University of Adelaide, Adelaide, SA, Australia.; Robinson Research Institute, The University of Adelaide, Adelaide, SA, Australia.; Department of Respiratory and Sleep Medicine, Women's and Children's Hospital, North Adelaide, SA, Australia., Donnelley M; Adelaide Medical School, The University of Adelaide, Adelaide, SA, Australia.; Robinson Research Institute, The University of Adelaide, Adelaide, SA, Australia.; Department of Respiratory and Sleep Medicine, Women's and Children's Hospital, North Adelaide, SA, Australia.
Publikováno v:
Gene therapy [Gene Ther] 2024 Aug 25. Date of Electronic Publication: 2024 Aug 25.
Akademický článek
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Akademický článek
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Autor:
Martin Donnelley, Patricia Cmielewski, Kaye Morgan, Juliette Delhove, Nicole Reyne, Alexandra McCarron, Nathan Rout-Pitt, Victoria Drysdale, Chantelle Carpentieri, Kathryn Spiers, Akihisa Takeuchi, Kentaro Uesugi, Naoto Yagi, David Parsons
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Gene vectors to treat cystic fibrosis lung disease should be targeted to the conducting airways, as peripheral lung transduction does not offer therapeutic benefit. Viral transduction efficiency is directly related to the vector residence ti
Externí odkaz:
https://doaj.org/article/8e5066133a14494fa29a90749fcb2c7c
To bead or not to bead: A review of Pseudomonas aeruginosa lung infection models for cystic fibrosis
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Cystic fibrosis (CF) lung disease is characterised by recurring bacterial infections resulting in inflammation, lung damage and ultimately respiratory failure. Pseudomonas aeruginosa is considered one of the most important lung pathogens in those wit
Externí odkaz:
https://doaj.org/article/969e444d6b584b46a13f2b92e4981943
Akademický článek
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