Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Cmax, Maximum plasma concentration"'
Autor:
Yaser Pashaei
Publikováno v:
Journal of Clinical Neuroscience
Graphical abstract
The current 2019 novel coronavirus disease (COVID-19), an emerging infectious disease, is undoubtedly the most challenging pandemic in the 21st century. A total of 92,977,768 confirmed cases of COVID-19 and 1,991,289 deaths we
The current 2019 novel coronavirus disease (COVID-19), an emerging infectious disease, is undoubtedly the most challenging pandemic in the 21st century. A total of 92,977,768 confirmed cases of COVID-19 and 1,991,289 deaths we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7aeeb00bbdbf0f68ba067697dc0f5a2
https://doi.org/10.1016/j.jocn.2021.03.010
https://doi.org/10.1016/j.jocn.2021.03.010
Publikováno v:
Toxicology Reports
Toxicology Reports, Vol 8, Iss, Pp 557-570 (2021)
Toxicology Reports, Vol 8, Iss, Pp 557-570 (2021)
Highlights • Four-week repeated-dose toxicity of intramuscular DSS was studied in minipigs. • DSS administration at ≥10 mg/kg/day causes toxicity and injection-site reaction. • The NOAEL of DSS after 4-week administration was 2 mg/kg/day in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b26ee397ae350858c363f15bad4a7b1
https://doi.org/10.1016/j.toxrep.2021.02.022
https://doi.org/10.1016/j.toxrep.2021.02.022
A Chitosan-PLGA based catechin hydrate nanoparticles used in targeting of lungs and cancer treatment
Autor:
Hassan Mohammed Ali Almatar, Aftab Alam, Ridha Abdullah Alrasheed, Rizwan Ahmad, Niyaz Ahmad, Taysser Mohammed Buheazah, Hassan Ali Al-Nasif, Hussain Salman AlHomoud, Abdullah Sami Al-Ramadan
Publikováno v:
Saudi Journal of Biological Sciences, Vol 27, Iss 9, Pp 2344-2357 (2020)
Saudi Journal of Biological Sciences
Saudi Journal of Biological Sciences
Objective: To prepare a novel Chitosan (CS)-coated-PLGA-NPs of catechin hydrate (CTH) and to improve lungs bioavailability via direct nose to lungs-delivery for the comparative assessment of a pulmokinetics study by the first-time UHPLC-MS/MS develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c0f4437da35e1616c448b65ec5fcee
http://www.sciencedirect.com/science/article/pii/S1319562X20301935
http://www.sciencedirect.com/science/article/pii/S1319562X20301935
Autor:
Zhuowei Liu, Yuxi Wang, Chengjian Zhao, Yang Zhang, Manyu Zhao, Jinliang Yang, Yuqin Yao, Peng Li, Chen Zhengxia, Xiaoxin Chen, Chaofeng Long
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1453-1475 (2020)
Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1453-1475 (2020)
Angiokinases, such as vascular endothelial-, fibroblast- and platelet-derived growth factor receptors (VEGFRs, FGFRs and PDGFRs) play crucial roles in tumor angiogenesis. Anti-angiogenesis therapy using multi-angiokinase inhibitor has achieved great
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a6380c470a4be26e380966eab21f579
http://europepmc.org/articles/PMC7488503
http://europepmc.org/articles/PMC7488503
Autor:
Aftab Alam, Abuzer Ali, Mohd Amir, Farhan Jalees Ahmad, Wasim Ahmad, Niyaz Ahmad, Rizwan Ahmad
Publikováno v:
Saudi Journal of Biological Sciences, Vol 27, Iss 1, Pp 500-517 (2020)
Saudi Journal of Biological Sciences
Saudi Journal of Biological Sciences
Graphical abstract
Objective Here, the aim is to improve the bioavailability of Naringenin (NRG) in brain and to establish the highest remedial benefit from a novel anti-ischemic medicine i.e. NRG. Methods A novel Naringenin-loaded-nanoemulsion
Objective Here, the aim is to improve the bioavailability of Naringenin (NRG) in brain and to establish the highest remedial benefit from a novel anti-ischemic medicine i.e. NRG. Methods A novel Naringenin-loaded-nanoemulsion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cbf9305501d6bea3502fb47e997e300
http://www.sciencedirect.com/science/article/pii/S1319562X19302402
http://www.sciencedirect.com/science/article/pii/S1319562X19302402
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 9, Iss 1, Pp 19-35 (2019)
Acta Pharmaceutica Sinica B, Vol 9, Iss 1, Pp 19-35 (2019)
In recent years, the coamorphous drug delivery system has been established as a promising formulation approach for delivering poorly water-soluble drugs. The coamorphous solid is a single-phase system containing an active pharmaceutical ingredient (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31cd90a5837aa2f7868b7856723ecc21
http://europepmc.org/articles/PMC6361732
http://europepmc.org/articles/PMC6361732
Publikováno v:
EBioMedicine, Vol 27, Iss C, Pp 134-137 (2018)
EBioMedicine
EBioMedicine
Background Clozapine is the most effective drug for treatment-resistant schizophrenia, but its use is limited by toxicity. Because ethnicity has been reported to affect clozapine metabolism, we compared its steady state pharmacokinetics in New Zealan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0391f6049664d464a19c45134f4372f5
http://www.sciencedirect.com/science/article/pii/S2352396417304747
http://www.sciencedirect.com/science/article/pii/S2352396417304747
Publikováno v:
Sexual Medicine
Sexual Medicine, Vol 9, Iss 5, Pp 100420-(2021)
Sexual Medicine, Vol 9, Iss 5, Pp 100420-(2021)
Introduction The use of current available treatment for male erectile dysfunction (ED) has some limitations that are related to efficacy and adverse effects. Nanotechnology has been used as a new tool in medicine to improve these limitations and new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::988f78ded40b56bb195b4168275d4262
https://doi.org/10.1016/j.esxm.2021.100420
https://doi.org/10.1016/j.esxm.2021.100420
Autor:
John Paul Fawcett, Tingting Wang, Yang He, Tianming Ren, Lei Yin, Huimin Sun, Yingjie Guo, Jingkai Gu
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 10, Pp 2002-2009 (2020)
Acta Pharmaceutica Sinica B, Vol 10, Iss 10, Pp 2002-2009 (2020)
Polyethylene glycols (PEGs) in general use are polydisperse molecules with molecular weight (MW) distributed around an average value applied in their designation e.g., PEG 4000. Previous research has shown that PEGs can act as P-glycoprotein (P-gp) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67944d5d71e648ebb23f796d4bcd2c2c
https://pubmed.ncbi.nlm.nih.gov/33163350
https://pubmed.ncbi.nlm.nih.gov/33163350
Autor:
Timothy G. Dinan, Conall R. Strain, Catherine Stanton, Fiona Fouhy, Gerard Clarke, Anna V. Golubeva, Sofia Cussotto, Alexander V. Zhdanov, Jacinta Walsh, John F. Cryan, Brendan T. Griffin, Niall P. Hyland
Publikováno v:
EBioMedicine, Vol 66, Iss, Pp 103307-(2021)
EBioMedicine
EBioMedicine
Background The role of the gut microbiome in the biotransformation of drugs has recently come under scrutiny. It remains unclear whether the gut microbiome directly influences the extent of drug absorbed after oral administration and thus potentially
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5790ae6c15583def027d28f1921431ba
https://doi.org/10.1016/j.ebiom.2021.103307
https://doi.org/10.1016/j.ebiom.2021.103307