The amyloid-β1-42-oligomer interacting peptide D-AIP possesses favorable biostability, pharmacokinetics, and brain region distribution

Autor: Adeola Shobo, Nicholas James, Daniel Dai, Alexander Röntgen, Corbin Black, Jean-Robert Kwizera, Mark A. Hancock, Khanh Huy Bui, Gerhard Multhaup

Publikováno v: The Journal of Biological Chemistry

We have previously developed a unique 8-amino acid Aβ42 oligomer-Interacting Peptide (AIP) as a novel anti-amyloid strategy for the treatment of Alzheimer's disease. Our lead candidate has successfully progressed from test tubes (i.e., in vitro char

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29a2223836effe65f042554ddc2330d
https://www.repository.cam.ac.uk/handle/1810/334182

Impact of chemical modification of sulfamidase on distribution to brain interstitial fluid and to CSF after an intravenous administration in awake, freely-moving rats

Autor: Joost H.A. Folgering, Maria Eriksson, Lars Bergquist, Gudrun Andersson, Juliette Janson

Publikováno v: Molecular Genetics and Metabolism Reports, Vol 22, Iss, Pp-(2020)
Molecular Genetics and Metabolism Reports

Mucopolysaccharidosis III A (MPS IIIA) is an autosomal recessive lysosomal storage disorder caused by deficiency of the enzyme sulfamidase. The disorder results in accumulation of heparan sulfate, lysosomal enlargement and cellular and organ dysfunct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5926859a8eba56927ab317fa4978ed
http://www.sciencedirect.com/science/article/pii/S221442691930196X

Drinks containing anthocyanin-rich blackcurrant extract decrease postprandial blood glucose, insulin and incretin concentrations

Autor: Danielle I. McCarthy, Rosalind J. Miller, Leanne Smith, Jonathan A. Farrimond, Monica L Castro-Acosta, Wendy L. Hall

Publikováno v: The Journal of Nutritional Biochemistry
Acosta, M L C, Smith, L, Miller, R J, McCarthy, D I, Farrimond, J A & Hall, W L 2016, ' Drinks containing anthocyanin-rich blackcurrant extract decrease postprandial blood glucose, insulin and incretin concentrations ', JOURNAL OF NUTRITIONAL BIOCHEMISTRY, vol. 38, pp. 154-161 . https://doi.org/10.1016/j.jnutbio.2016.09.002

Blackcurrants are rich in polyphenolic glycosides called anthocyanins, which may inhibit postprandial glycemia. The aim was to determine the dose-dependent effects of blackcurrant extract on postprandial glycemia. Men and postmenopausal women (14 M,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43673c33f67fb3816787571fd0679dff

Need to Face Liver Cirrhosis after HCV Cure with Antivirals

Autor: Pablo Barreiro, Ana Arias, Laura Benitez, Vicente Soriano, Carmen de Mendoza

Publikováno v: EBioMedicine, Vol 24, Iss C, Pp 24-25 (2017)
EBioMedicine
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid

Background There is currently no anti-fibrotic drug therapy available to treat hepatitis C virus (HCV) cirrhosis. The aim of this study was to assess the safety, tolerability, and anti-fibrotic effect of PRI-724, a small-molecule modulator of Wnt sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19560635ad7662d3551076ef6e0bdd43
http://www.sciencedirect.com/science/article/pii/S2352396417303390

Hereditary and acquired angioedema: Problems and progress: Proceedings of the third C1 esterase inhibitor deficiency workshop and beyond

Autor: Peter J. Späth, E. Rusicke, Christoph Bucher, Alvaro Blanch, Olga Roche, Emanuela Pappalardo, István Karádi, Marco Cicardi, Mathias Juers, Inmaculada Martinez-Saguer, Roberto Giacomelli, Pál Novák Kaposi, Anthony J. Castaldo, Erik Waage Nielsen, Roberto Perricone, Arianna Kitzinger, Kalman Fay, Emel Aygören-Pürsün, Carlo Perricone, Christian Drouet, George Füst, Beáta Visy, C. Erik Hack, Vincenzo Penna, Hilary Longhurst, Tímea Kollár, George Harmat, István Nagy, Nicole Monnier, Éva Németh, Jan H. Nuijens, Bettina Fischer, Ursula Rauch, Peter L. Lakatos, Caterina De Carolis, Caroline O'Grady, Edit Takács, Margarita López-Trascasa, Henriette Farkas, Albrecht Gröner, George Szendei, Lilian Varga, Alvin E. Davis, Lennart Truedsson, Béla Fekete, John Jakenfelds, Andrea Zanichelli, Wolfhart Kreuz, Kayla Williams, Lajos Kalmar, Lorenza C. Zingale, Karen Binkley, Christiane Duponchel, Laurence Bouillet, Attila Tordai, Luigi Fontana, Angelo Agostoni, Konrad Bork

Publikováno v: The Journal of Allergy and Clinical Immunology

Hereditary angioedema (HAE), a rare but life-threatening condition, manifests as acute attacks of facial, laryngeal, genital, or peripheral swelling or abdominal pain secondary to intra-abdominal edema. Resulting from mutations affecting C1 esterase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683368948c5151ac254b136230a7bd26
https://doi.org/10.1016/j.jaci.2004.06.047