Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes.

Autor: Guo JL; Denali Therapeutics Inc., South San Francisco, CA, USA. Electronic address: guojing84@hotmail.com., Braun D; Denali Therapeutics Inc., South San Francisco, CA, USA., Fitzgerald GA; Denali Therapeutics Inc., South San Francisco, CA, USA., Hsieh YT; Denali Therapeutics Inc., South San Francisco, CA, USA., Rougé L; Denali Therapeutics Inc., South San Francisco, CA, USA., Litvinchuk A; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Steffek M; Denali Therapeutics Inc., South San Francisco, CA, USA., Propson NE; Denali Therapeutics Inc., South San Francisco, CA, USA., Heffner CM; Denali Therapeutics Inc., South San Francisco, CA, USA., Discenza C; Denali Therapeutics Inc., South San Francisco, CA, USA., Han SJ; Denali Therapeutics Inc., South San Francisco, CA, USA., Rana A; Denali Therapeutics Inc., South San Francisco, CA, USA., Skuja LL; Denali Therapeutics Inc., South San Francisco, CA, USA., Lin BQ; Denali Therapeutics Inc., South San Francisco, CA, USA., Sun EW; Denali Therapeutics Inc., South San Francisco, CA, USA., Davis SS; Denali Therapeutics Inc., South San Francisco, CA, USA., Balasundar S; Denali Therapeutics Inc., South San Francisco, CA, USA., Becerra I; Denali Therapeutics Inc., South San Francisco, CA, USA., Dugas JC; Denali Therapeutics Inc., South San Francisco, CA, USA., Ha C; Denali Therapeutics Inc., South San Francisco, CA, USA., Hsiao-Nakamoto J; Denali Therapeutics Inc., South San Francisco, CA, USA., Huang F; Denali Therapeutics Inc., South San Francisco, CA, USA., Jain S; Denali Therapeutics Inc., South San Francisco, CA, USA., Kung JE; Denali Therapeutics Inc., South San Francisco, CA, USA., Liau NPD; Denali Therapeutics Inc., South San Francisco, CA, USA., Mahon CS; Denali Therapeutics Inc., South San Francisco, CA, USA., Nguyen HN; Denali Therapeutics Inc., South San Francisco, CA, USA., Nguyen N; Denali Therapeutics Inc., South San Francisco, CA, USA., Samaddar M; Denali Therapeutics Inc., South San Francisco, CA, USA., Shi Y; Denali Therapeutics Inc., South San Francisco, CA, USA., Tatarakis D; Denali Therapeutics Inc., South San Francisco, CA, USA., Tian Y; Denali Therapeutics Inc., South San Francisco, CA, USA., Zhu Y; Denali Therapeutics Inc., South San Francisco, CA, USA., Suh JH; Denali Therapeutics Inc., South San Francisco, CA, USA., Sandmann T; Denali Therapeutics Inc., South San Francisco, CA, USA., Calvert MEK; Denali Therapeutics Inc., South San Francisco, CA, USA., Arguello A; Denali Therapeutics Inc., South San Francisco, CA, USA., Kane LA; Denali Therapeutics Inc., South San Francisco, CA, USA., Lewcock JW; Denali Therapeutics Inc., South San Francisco, CA, USA., Holtzman DM; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Koth CM; Denali Therapeutics Inc., South San Francisco, CA, USA., Di Paolo G; Denali Therapeutics Inc., South San Francisco, CA, USA. Electronic address: dipaolo@dnli.com.

Publikováno v: Cell [Cell] 2024 Nov 11. Date of Electronic Publication: 2024 Nov 11.

Structural and functional diversity calls for a new classification of ABC transporters.

Autor: Thomas C; Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Germany., Aller SG; Department of Pharmacology and Toxicology, University of Alabama at Birmingham, AL, USA., Beis K; Department of Life Sciences, Imperial College London, London South Kensington, UK.; Rutherford Appleton Laboratory, Research Complex at Harwell, Didcot, UK., Carpenter EP; Structural Genomics Consortium, University of Oxford, UK., Chang G; Skaggs School of Pharmacy and Pharmaceutical Sciences and Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA, USA., Chen L; State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, China.; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China., Dassa E; Institut Pasteur, Paris Cedex 15, France., Dean M; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Gaithersburg, MD, USA., Duong Van Hoa F; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada., Ekiert D; Department of Cell Biology and Department of Microbiology, New York University School of Medicine, NY, USA., Ford R; Faculty of Biology, Medicine and Health, The University of Manchester, UK., Gaudet R; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA., Gong X; Department of Biology, Southern University of Science and Technology, Shenzhen, China., Holland IB; Institute for Integrative Biology of the Cell (I2BC), Université Paris-Sud, Orsay, France., Huang Y; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China., Kahne DK; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Kato H; Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Japan., Koronakis V; Department of Pathology, University of Cambridge, UK., Koth CM; Structural Biology, Genentech Inc., South San Francisco, CA, USA., Lee Y; Division of Integrative Bioscience and Biotechnology, POSTECH, Pohang, Korea., Lewinson O; Department of Biochemistry, The Bruce and Ruth Rappaport Faculty of Medicine, The Technion-Israel Institute of Technology, Haifa, Israel., Lill R; Institut für Zytobiologie, Philipps-Universität Marburg, Germany., Martinoia E; Department of Plant and Microbial Biology, University Zurich, Switzerland.; International Research Centre for Environmental Membrane Biology, Foshan University, Foshan, China., Murakami S; Department of Life Science, Tokyo Institute of Technology, Yokohama, Japan., Pinkett HW; Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA., Poolman B; Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, The Netherlands., Rosenbaum D; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA., Sarkadi B; Institute of Enzymology, Research Center for Natural Sciences (RCNS), Budapest, Hungary., Schmitt L; Institute of Biochemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Schneider E; Department of Biology/Microbial Physiology, Humboldt-University of Berlin, Germany., Shi Y; Institute of Biology, Westlake Institute for Advanced Study, School of Life Sciences, Westlake University, Hangzhou, China., Shyng SL; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR, USA., Slotboom DJ; Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, The Netherlands., Tajkhorshid E; Department of Biochemistry, Center for Biophysics and Quantitative Biology, NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, IL, USA., Tieleman DP; Department of Biological Sciences and Centre for Molecular Simulation, University of Calgary, AB, Canada., Ueda K; Institute for Integrated Cell-Material Sciences (WPI-iCeMS), KUIAS, Kyoto University, Japan., Váradi A; Institute of Enzymology, Research Center for Natural Sciences (RCNS), Budapest, Hungary., Wen PC; Department of Biochemistry, Center for Biophysics and Quantitative Biology, NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, IL, USA., Yan N; Department of Molecular Biology, Princeton University, NJ, USA., Zhang P; National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China., Zheng H; Department of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Zimmer J; Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA., Tampé R; Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Germany.

Publikováno v: FEBS letters [FEBS Lett] 2020 Dec; Vol. 594 (23), pp. 3767-3775. Date of Electronic Publication: 2020 Oct 26.

Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab.

Autor: Rougé L; Department of Structural Biology, Genentech Inc., South San Francisco, CA 94080, USA., Chiang N; Department of Antibody Engineering, Genentech Inc., South San Francisco, CA 94080, USA., Steffek M; Department of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA 94080, USA., Kugel C; Department of Biomolecular Resources, Genentech Inc., South San Francisco, CA 94080, USA., Croll TI; Cambridge Institute for Medical Research, University of Cambridge, Keith Peters Building, Cambridge CB2 0XY, UK., Tam C; Department of Biomolecular Resources, Genentech Inc., South San Francisco, CA 94080, USA., Estevez A; Department of Structural Biology, Genentech Inc., South San Francisco, CA 94080, USA., Arthur CP; Department of Structural Biology, Genentech Inc., South San Francisco, CA 94080, USA., Koth CM; Department of Structural Biology, Genentech Inc., South San Francisco, CA 94080, USA., Ciferri C; Department of Structural Biology, Genentech Inc., South San Francisco, CA 94080, USA., Kraft E; Department of Biomolecular Resources, Genentech Inc., South San Francisco, CA 94080, USA., Payandeh J; Department of Structural Biology, Genentech Inc., South San Francisco, CA 94080, USA. rohou.alexis@gene.com koerber.james@gene.com nakamura.gerald@gene.com payandeh.jian@gene.com.; Department of Antibody Engineering, Genentech Inc., South San Francisco, CA 94080, USA., Nakamura G; Department of Antibody Engineering, Genentech Inc., South San Francisco, CA 94080, USA. rohou.alexis@gene.com koerber.james@gene.com nakamura.gerald@gene.com payandeh.jian@gene.com., Koerber JT; Department of Antibody Engineering, Genentech Inc., South San Francisco, CA 94080, USA. rohou.alexis@gene.com koerber.james@gene.com nakamura.gerald@gene.com payandeh.jian@gene.com., Rohou A; Department of Structural Biology, Genentech Inc., South San Francisco, CA 94080, USA. rohou.alexis@gene.com koerber.james@gene.com nakamura.gerald@gene.com payandeh.jian@gene.com.

Publikováno v: Science (New York, N.Y.) [Science] 2020 Mar 13; Vol. 367 (6483), pp. 1224-1230. Date of Electronic Publication: 2020 Feb 20.

Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin.

Autor: Xu H, Li T, Rohou A, Arthur CP, Tzakoniati F, Wong E, Estevez A, Kugel C, Franke Y, Chen J, Ciferri C, Hackos DH, Koth CM, Payandeh J

Publikováno v: Cell [Cell] 2019 Feb 21; Vol. 176 (5), pp. 1238-1239.

Disrupting Gram-Negative Bacterial Outer Membrane Biosynthesis through Inhibition of the Lipopolysaccharide Transporter MsbA.

Autor: Alexander MK; Genentech, Inc., Infectious Diseases, South San Francisco, California, USA maryca@gene.com mireille.nishiyama@gmail.com., Miu A; Genentech, Inc., Biochemical and Cellular Pharmacology, South San Francisco, California, USA., Oh A; Genentech, Inc., Structural Biology, South San Francisco, California, USA., Reichelt M; Genentech, Inc., Pathology, South San Francisco, California, USA., Ho H; Genentech, Inc., Structural Biology, South San Francisco, California, USA., Chalouni C; Genentech, Inc., Pathology, South San Francisco, California, USA., Labadie S; Genentech, Inc., Discovery Chemistry, South San Francisco, California, USA., Wang L; Genentech, Inc., Discovery Chemistry, South San Francisco, California, USA., Liang J; Genentech, Inc., Discovery Chemistry, South San Francisco, California, USA., Nickerson NN; Genentech, Inc., Infectious Diseases, South San Francisco, California, USA., Hu H; Genentech, Inc., Discovery Chemistry, South San Francisco, California, USA., Yu L; WuXi AppTec Co. Ltd., Shanghai, China., Du M; WuXi AppTec Co. Ltd., Shanghai, China., Yan D; Genentech, Inc., Translational Immunology, South San Francisco, California, USA., Park S; Genentech, Inc., Translational Immunology, South San Francisco, California, USA., Kim J; Genentech, Inc., Translational Immunology, South San Francisco, California, USA., Xu M; Genentech, Inc., Translational Immunology, South San Francisco, California, USA., Sellers BD; Genentech, Inc., Discovery Chemistry, South San Francisco, California, USA., Purkey HE; Genentech, Inc., Discovery Chemistry, South San Francisco, California, USA., Skelton NJ; Genentech, Inc., Discovery Chemistry, South San Francisco, California, USA., Koehler MFT; Genentech, Inc., Discovery Chemistry, South San Francisco, California, USA., Payandeh J; Genentech, Inc., Structural Biology, South San Francisco, California, USA., Verma V; Genentech, Inc., Discovery Chemistry, South San Francisco, California, USA., Xu Y; Genentech, Inc., Biochemical and Cellular Pharmacology, South San Francisco, California, USA., Koth CM; Genentech, Inc., Structural Biology, South San Francisco, California, USA., Nishiyama M; Genentech, Inc., Infectious Diseases, South San Francisco, California, USA maryca@gene.com mireille.nishiyama@gmail.com.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2018 Oct 24; Vol. 62 (11). Date of Electronic Publication: 2018 Oct 24 (Print Publication: 2018).