Systems Vaccinology in HIV Vaccine Development

Autor: Jielin Zhang, Philip Askenase, Clyde S. Crumpacker

Publikováno v: Vaccines, Vol 10, Iss 10, p 1624 (2022)

Themes of discussions in the Special Issue of T Cell Immunity and HIV-1 Pathogenicity are outlined here [...]

Externí odkaz: https://doaj.org/article/edc7601d044544b4a24004c711e4e939

Drug Resistance Mutations and Associated Phenotypes Detected in Clinical Trials of Maribavir for Treatment of Cytomegalovirus Infection

Autor: Jingyang Wu, Clyde S. Crumpacker, Kening Song, Sunwen Chou, Tien Bo

Publikováno v: The Journal of Infectious Diseases. 226:576-584

Background In separate phase 2 trials, 120 patients received maribavir for cytomegalovirus (CMV) infection failing conventional therapy (trial 202) and 119 received maribavir for asymptomatic infection (trial 203). Overall, 172 cleared their CMV infe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3f1e5a362beaf38c129b169c01fea0c
https://doi.org/10.1093/infdis/jiaa462

Reverse transcriptase mutation K65N confers a decreased replication capacity to HIV-1 in comparison to K65R due to a decreased RT processivity

Autor: Clyde S. Crumpacker, Prem L. Sharma, HimaBindu Chunduri

Publikováno v: Virology. 414(1):34-41

In addition to K65R, the other mutation observed at HIV-1 RT codon 65 is K65N. While K65N appears to have a phenotypic effect similar to K65R, it is less frequent during clinical trials. We compared the relative impact of K→N with respect to K→R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a3aafc1c785037ab9f66c103ee5d502

Rapid and Durable Antiretroviral Effect of the HIV-1 Integrase Inhibitor Raltegravir as Part of Combination Therapy in Treatment-Naive Patients With HIV-1 Infection

Autor: Hong Wan, Hedy Teppler, Larissa Wenning, Fernando Mendo, Bach-Yen Nguyen, Clyde S. Crumpacker, Guillermo Prada, Robin Isaacs, Colin Kovacs, Winai Ratanasuwan, Eduardo Gotuzzo, Michael D. Miller, Lucinda R. Gilde, Javier O Morales-Ramirez, Martin Markowitz

Publikováno v: JAIDS Journal of Acquired Immune Deficiency Syndromes. 46:125-133

BACKGROUND Raltegravir is an HIV-1 integrase strand-transfer inhibitor with potent in vitro activity. This study explored the antiretroviral activity and safety of raltegravir in treatment-naive patients with plasma HIV-1 RNA levels > or = 5000 copie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::499ee17c1d65724f68a7e210b7c5a23f
https://doi.org/10.1097/qai.0b013e318157131c

Contributors

Autor: Kjersti Aagaard, Fredrick M. Abrahamian, Ban Mishu Allos, David R. Andes, Fred Y. Aoki, Michael A. Apicella, Kevin L. Ard, Cesar A. Arias, David M. Aronoff, Michael H. Augenbraun, Francisco Averhoff, Dimitri T. Azar, Larry M. Baddour, Lindsey R. Baden, Carol J. Baker, Ronald C. Ballard, Gerard R. Barber, Scott D. Barnes, Dan H. Barouch, Alan D. Barrett, Miriam Baron Barshak, Sridhar V. Basavaraju, Byron E. Batteiger, Stephen G. Baum, Arnold S. Bayer, J. David Beckham, Susan E. Beekmann, Beth P. Bell, John E. Bennett, Dennis A. Bente, Elie F. Berbari, Jonathan Berman, Joseph S. Bertino, Adarsh Bhimraj, Holly H. Birdsall, Alan L. Bisno, Brian G. Blackburn, Lucas S. Blanton, Martin J. Blaser, Thomas P. Bleck, Nicole M.A. Blijlevens, David A. Bobak, William Bonnez, John C. Boothroyd, Luciana L. Borio, Patrick J. Bosque, John Bower, Robert W. Bradsher, Itzhak Brook, Kevin E. Brown, Patricia D. Brown, Barbara A. Brown-Elliott, Roberta L. Bruhn, Amy E. Bryant, Eileen M. Burd, Jane C. Burns, Larry M. Bush, Stephen B. Calderwood, Luz Elena Cano, Charles C.J. Carpenter, Mary T. Caserta, Elio Castagnola, Richard E. Chaisson, Henry F. Chambers, Stephen J. Chapman, James D. Chappell, Lea Ann Chen, Sharon C-A Chen, Anthony W. Chow, Rebecca A. Clark, Jeffrey I. Cohen, Myron S. Cohen, Ronit Cohen-Poradosu, Susan E. Cohn, Mark Connors, Lawrence Corey, Mackenzie L. Cottrell, Timothy L. Cover, Heather L. Cox, William A. Craig, Kent B. Crossley, Clyde S. Crumpacker, James W. Curran, Bart J. Currie, Erika D'Agata, Inger K. Damon, Rabih O. Darouiche, Roberta L. DeBiasi, George S. Deepe, Carlos del Rio, Andrew S. Delemos, Frank R. DeLeo, Gregory P. DeMuri, Peter Densen, Terence S. Dermody, Robin Dewar, James H. Diaz, Carl W. Dieffenbach, Jules L. Dienstag, Yohei Doi, Raphael Dolin, J. Peter Donnelly, Michael S. Donnenberg, Gerald R. Donowitz, Philip R. Dormitzer, James M. Drake, J. Stephen Dumler, J. Stephen Dummer, Herbert L. DuPont, David T. Durack, Marlene L. Durand, Paul H. Edelstein, Michael B. Edmond, John E. Edwards, Morven S. Edwards, George M. Eliopoulos, Richard T. Ellison, Timothy P. Endy, N. Cary Engleberg, Hakan Erdem, Joel D. Ernst, Peter B. Ernst, Rick M. Fairhurst, Jessica K. Fairley, Stanley Falkow, Ann R. Falsey, Anthony S. Fauci, Thomas Fekete, Paul D. Fey, Steven M. Fine, Daniel W. Fitzgerald, Anthony R. Flores, Derek Forster, Vance G. Fowler, David O. Freedman, Arthur M. Friedlander, John N. Galgiani, John I. Gallin, Robert C. Gallo, Tejal N. Gandhi, Wendy S. Garrett, Charlotte A. Gaydos, Thomas W. Geisbert, Jeffrey A. Gelfand, Steven P. Gelone, Dale N. Gerding, Anne A. Gershon, Janet R. Gilsdorf, Ellie J.C. Goldstein, Fred M. Gordin, Paul S. Graman, M. Lindsay Grayson, Jeffrey Bruce Greene, Patricia M. Griffin, David E. Griffith, Richard L. Guerrant, H. Cem Gul, David A. Haake, David W. Haas, Charles Haines, Caroline Breese Hall, Joelle Hallak, Scott A. Halperin, Margaret R. Hammerschlag, Rashidul Haque, Jason B. Harris, Claudia Hawkins, Roderick J. Hay, Craig W. Hedberg, David K. Henderson, Donald A. Henderson, Kevin P. High, Adrian V.S. Hill, David R. Hill, Alan R. Hinman, Martin S. Hirsch, Aimee Hodowanec, Tobias M. Hohl, Steven M. Holland, Robert S. Holzman, Edward W. Hook, David C. Hooper, Thomas M. Hooton, Harold W. Horowitz, C. Robert Horsburgh, James M. Horton, Duane R. Hospenthal, Kevin Hsueh, James M. Hughes, Noreen A. Hynes, Nicole M. Iovine, Jonathan R. Iredell, Michael G. Ison, J. Michael Janda, Edward N. Janoff, Eric C. Johannsen, Angela D.M. Kashuba, Dennis L. Kasper, Donald Kaye, Keith S. Kaye, Kenneth M. Kaye, James W. Kazura, Jay S. Keystone, Rima Khabbaz, David A. Khan, Yury Khudyakov, Rose Kim, Charles H. King, Louis V. Kirchhoff, Jerome O. Klein, Michael Klompas, Bettina M. Knoll, Kirk U. Knowlton, Jane E. Koehler, Stephan A. Kohlhoff, Eija Könönen, Dimitrios P. Kontoyiannis, Igor J. Koralnik, Poonum S. Korpe, Anita A. Koshy, Joseph A. Kovacs, Phyllis Kozarsky, John Krieger, Andrew T. Kroger, Matthew J. Kuehnert, Nalin M. Kumar, Merin Elizabeth Kuruvilla, Regina C. LaRocque, James E. Leggett, Helena Legido-Quigley, Paul N. Levett, Donald P. Levine, Matthew E. Levison, Alexandra Levitt, Russell E. Lewis, W. Conrad Liles, Aldo A.M. Lima, Ajit P. Limaye, W. Ian Lipkin, Nathan Litman, Bennett Lorber, Ruth Ann Luna, Conan MacDougall, Rob Roy, Philip A. Mackowiak, Lawrence C. Madoff, Alan J. Magill, James H. Maguire, Frank Maldarelli, Lewis Markoff, Jeanne M. Marrazzo, Thomas J. Marrie, Thomas Marth, David H. Martin, Gregory J. Martin, Francisco M. Marty, Melanie Jane Maslow, Henry Masur, Alison Mawle, Kenneth H. Mayer, John T. McBride, James S. McCarthy, William M. McCormack, Catherine C. McGowan, Kenneth McIntosh, Paul S. Mead, Malgorzata Mikulska, Robert F. Miller, Samuel I. Miller, David H. Mitchell, John F. Modlin, Rajal K. Mody, Robert C. Moellering, Matthew Moffa, Susan Moir, José G. Montoya, Thomas A. Moore, Philippe Moreillon, J. Glenn Morris, Caryn Gee Morse, Robin Moseley, Robert S. Munford, Edward L. Murphy, Timothy F. Murphy, Barbara E. Murray, Clinton K. Murray, Patrick R. Murray, Daniel M. Musher, Jerod L. Nagel, Esteban C. Nannini, Anna Narezkina, Theodore E. Nash, William M. Nauseef, Jennifer L. Nayak, Marguerite A. Neill, Judith A. O'Donnell, Christopher A. Ohl, Pablo C. Okhuysen, Andrew B. Onderdonk, Steven M. Opal, Walter A. Orenstein, Douglas R. Osmon, Michael T. Osterholm, Stephen M. Ostroff, Michael N. Oxman, Slobodan Paessler, Andrea V. Page, Manjunath P. Pai, Tara N. Palmore, Raj Palraj, Peter G. Pappas, Mark S. Pasternack, Thomas F. Patterson, Deborah Pavan-Langston, David A. Pegues, Robert L. Penn, John R. Perfect, Stanley Perlman, Brett W. Petersen, Phillip K. Peterson, William A. Petri, Cathy A. Petti, Jennifer A. Philips, Julie V. Philley, Michael Phillips, Larry K. Pickering, Peter Piot, Jason M. Pogue, Aurora Pop-Vicas, Cynthia Portal-Celhay, John H. Powers, Richard N. Price, Yok-Ai Que, Justin D. Radolf, Sanjay Ram, Didier Raoult, Jonathan I. Ravdin, Stuart C. Ray, Annette C. Reboli, Marvin S. Reitz, David A. Relman, Cybèle A. Renault, Angela Restrepo, John H. Rex, Elizabeth G. Rhee, Norbert J. Roberts, José R. Romero, Alan L. Rothman, Craig R. Roy, Kathryn L. Ruoff, Mark E. Rupp, Charles E. Rupprecht, Thomas A. Russo, William A. Rutala, Edward T. Ryan, Amar Safdar, Mohammad M. Sajadi, Juan C. Salazar, Juan Carlos Sarria, Maria C. Savoia, Paul E. Sax, W. Michael Scheld, Joshua T. Schiffer, David Schlossberg, Thomas Schneider, Anne Schuchat, Jane R. Schwebke, Cynthia L. Sears, Leopoldo N. Segal, Parham Sendi, Kent A. Sepkowitz, Edward J. Septimus, Alexey Seregin, Stanford T. Shulman, George K. Siberry, Omar K. Siddiqi, Costi D. Sifri, Michael S. Simberkoff, Francesco R. Simonetti, Kamaljit Singh, Nina Singh, Upinder Singh, Scott W. Sinner, Sumathi Sivapalasingam, Leonard N. Slater, A. George Smulian, Jack D. Sobel, M. Rizwan Sohail, David E. Soper, Tania C. Sorrell, James M. Steckelberg, Allen C. Steere, Neal H. Steigbigel, James P. Steinberg, David S. Stephens, Timothy R. Sterling, David A. Stevens, Dennis L. Stevens, Jacob Strahilevitz, Charles W. Stratton, Anthony F. Suffredini, Kathryn N. Suh, Mark S. Sulkowski, Morton N. Swartz, Thomas R. Talbot, C. Sabrina Tan, Ming Tan, Chloe Lynne Thio, David L. Thomas, Lora D. Thomas, Stephen J. Thomas, Anna R. Thorner, Angela María Tobón, Edmund C. Tramont, John J. Treanor, Jason Trubiano, Athe M.N. Tsibris, Allan R. Tunkel, Ronald B. Turner, Kenneth L. Tyler, Ahmet Uluer, Diederik van de Beek, Walter J.F.M. van der Velden, Edouard G. Vannier, Trevor C. Van, James Versalovic, Claudio Viscoli, Ellen R. Wald, Matthew K. Waldor, David H. Walker, Richard J. Wallace, Edward E. Walsh, Stephen R. Walsh, Peter D. Walzer, Christine A. Wanke, Cirle A. Warren, Ronald G. Washburn, Valerie Waters, David J. Weber, Michael D. Weiden, Geoffrey A. Weinberg, Daniel J. Weisdorf, Louis M. Weiss, David F. Welch, Thomas E. Wellems, Richard P. Wenzel, Melinda Wharton, A. Clinton White, Richard J. Whitley, Walter R. Wilson, Glenn W. Wortmann, William F. Wright, Jo-Anne H. Young, Vincent B. Young, Nadezhda Yun, Werner Zimmerli, Stephen H. Zinner, John J. Zurlo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba8385fb17ad0134e4ffe28a70408b81
https://doi.org/10.1016/b978-1-4557-4801-3.00327-1